Targeted Therapy is revolutionizing cancer treatment by being highly specific and causing fewer side effects. It represents a new hope for more positive outcomes by precisely targeting the exact causes of cancer, such as defective genes, molecules, proteins etc. This therapy's targets are based on bio marker profiling through next generation sequencing techniques. Doctor prescribe multiple targeted therapeutic drugs such as Erlonat 100 mg Tablet, Imat 400 mg Tablet, Veenat 400 mg Tablet, Sunitinib 50 mg Capsule,Lenvima 10 mg Capsule etc. Lets explore the revolutionized method of cancer treatment with its common key medicines and their uses.
What is Targeted Therapy?
Following are the characteristic features of Target Therapy:
Specifically, these extremely targeted treatments solely address the underlying cause of the development of cancer.
It targets specific faulty receptor, faulty protein, abnormal enzyme synthesis, or genetic mutations.
In addition to having fewer adverse effects than other traditional therapy, these treatments guarantee hitting the exact root cause of cancer.
A doctor must find out a specific target that is causing cancer. For example, genetic mutation or receptor etc. This assessment can be made through molecular testing or bio marker profiling.
Molecular testing :
It is also called bio marker profiling. This method assesses the protein expression or genetic makeup to find out a particular bio marker that can be used as a target for medicine.
Following is the way in which Molecular Testing Works:
Molecular testing begins with sample collection of cancer cells though Biopsy.
After that, next generation sequencing techniques such as Genomic Profiling allows find exact bio marker.
Cancers treated by Target therapy
Following is the list of cancers treated by Target Therapy:
Non Small Cell Lung Cancer with EGFR mutation
Chronic Myeloid Leukemia
Gastrointestinal Stromal Tumors
Pancreatic Cancer
Philadelphia chromosome‑positive acute lymphoblastic leukaemia
Breast Cancer
Kidney Cancer
Pancreatic Endocrine Tumors etc.
How Targeted Therapy Works?
Following are the mechanisms by which a Target Therapy Works:
Blocking Signals: Cancer cells require signals to grow via cellular machinery. But, a certain class of salt blocks the cell signaling pathway to prevent cancer cell growth. For example Everolimus inhibits mechanistic Target of Rapamycin cell signaling pathway. As a result, it inhibits cancer cell growth.
Triggering Self Cell Death:Certain class of targeted therapeutic drug activates signals that promote apoptosis (cell death). As a result, cancer cells die due to self-killing mechanism.
Blocks Angiogenesis:Drug salt blocks the key enzymes or proteins responsible for blood vessels formation that promotes growth. As a result, prevent further growing of cancer.
Direct Cancer Cell Killing:Antibody-Drug Conjugates contains monoclonal antibodies that are highly target specific. As a result, it directly kills the cancer cells.
All these working mechanisms make them highly effective with fewer effects. In particular, it is all due to the target specific nature of targeted therapy.
Key Targeted Therapy Medicines and Their Uses
Following are the targeted therapy medicines with their uses:
Erlonat 100 mg Tablet:
Erlonat 100 mg Tablet treats Non Small Cell Lung Cancer with EGFR mutation and Pancreatic Cancer.
Erlotinib salt blocks the Endothelial Growth Factor Receptor. As a result, inhibit cancer cell growth.
Side effects include Skin Rash, Fatigue, Loss of Appetite etc.
Imat 400 mg Tablet:
Imat 400 mg Tablet treats Chronic Myeloid Leukemia, Acute Lymphoblastic Leukemia Gastrointestinal Stromal Tumors and rare cancers such as Myelodysplastic.
Imatinib Mesylate salt blocks tyrosine kinases such as BCR-ABL, c-Kit etc. As a result, cancer cell proliferation stops.
Side effects include Fluid Retention, Fatigue, Nausea etc.
Veenat 400 mg Tablet:
Veenat 400 mg Tablet treats Chronic Myeloid Leukemia, Gastrointestinal Stromal Tumors, Philadelphia chromosome‑positive acute lymphoblastic leukemia and rare cancers such as Myelodysplastic.
Imatinib salt blocks tyrosine kinases such as BCR-ABL, c-Kit etc. As a result, cancer cell proliferation stops.
Side effects include Skin Reaction, Edema, Headache etc.
Sunitinib 50 mg Capsule
Sunitinib 50 mg Capsule treats Advanced Kidney Cancer, Pancreatic Endocrine Tumors and Gastrointestinal Stromal Tumors.
Sunitinib Malate salt blocks tyrosine kinases such as BCR-ABL, c-Kit etc. As a result, cancer cell proliferation stops.
Side effects include Fatigue, Hypertension, Hyporthyroidism etc.
Sutinat 12.5 mg Capsule:
It treats Advanced Kidney Cancer, Pancreatic NeuroEndocrine Tumors and Gastrointestinal Stromal Tumors.
Sunitinib Malate salt blocks tyrosine kinases such as VEGFR, PDGFR, c-Kit etc. As a result, cancer cell proliferation stops.
Side effects include Fatigue, Skin Reaction, Hair Changes etc.
Lenvima 10 mg Capsule:
It treats Thyroid Carcinoma and hepatocellular carcinoma.
Lenvatinib blocks the tyrosine kinases key enzymes. Such as VEGFR1, FGFR1 ETC. As a result, it inhibits cancer cell growth.
Side effects include Weight Loss, Abdominal pain, Skin Reactions etc.
Regonat 40 mg Tablet:
It treats Metastatic Colorectal Cancer, hepatocellular carcinoma and Gastrointestinal Stromal Tumors.
Regorafenib blocks signaling pathways that supports cancer blood vessel formation. As a result, prevent cancer cell growth.
Side effects include Weakness, Hair Loss, High Blood Pressure etc.
Evermil 5 mg Table:
It treats HR+ Breast Cancer, Advanced Kidney Cancer, Pancreatic Neuroendocrine Tumors and certain Brain Tumors.
Everolimus inhibits mechanistic Target of Rapamycin pathway that promote cancer cell growth. As a result, cancer proliferation stops.
Side effects include Mouth Sores, Swelling, Kidney Problem etc.
Advantages Over Conventional therapies
Following are the advantages of Targeted Therapy over conventional ones:
High Target Specificity
Less Side Effects
High Efficacy
Faster Response
Conclusion
In conclusion, Targeted Therapy in cancer treatment focuses on specific genetic mutations and abnormal proteins, aiming to minimize side effects compared to traditional methods. It utilizes bio marker profiling through molecular testing to determine medication targets, such as Erlonat, Imat, Veenat, Sunitinib, and Lenvima. This approach is effective for treating cancers like Non-Small Cell Lung Cancer, Chronic Myeloid Leukemia, and Breast Cancer, by blocking cell signaling, inducing apoptosis, inhibiting angiogenesis, and directly destroying cancer cells. To get huge discounts on these cancer medicines, visit Magicine Pharma now.
FAQs
1. Are Targeted Therapies more effective?
A-Yes, Target therapies are highly effective due to their target specific nature.
2. What are some of the common side effects of Target Therapeutic Drugs?
A-Some of the common side effects of Target Therapeutic Drugs are hair loss, weakness, nausea etc.
References:
https://www.cancer.org/cancer/managing-cancer/treatment-types/targeted-therapy.html
https://my.clevelandclinic.org/health/treatments/22733-targeted-therapy
https://www.carislifesciences.com/patients/fight-cancer-smarter/biomarker/
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