ZOLEDRONIC ACID 4MG INJECTION (ZOLTERO)

Side effects of Zoledronic Acid 4mg Injection

This medicine may cause some major and minor side effects. Discuss the risks and benefits of this medication with the doctor before starting the treatment.  

Common side effects  

• Diarrhea  

• Nausea  

• Fatigue  

• Constipation  

• Bone pain  

• Vomiting  

• Fever  

• Anemia  

• Heartburn  

• Stomach pain  

• Irregular heartbeat  

• Difficulty with swallowing  

• Loss of appetite  

• Pain at the injection site  

• Redness or swelling in the eyes  

• Dizziness  

• Headache  

• Joint pain  

• Muscle pain  

• Constipation  

• Sore throat  

• Hypersensitive  

• Seizures  

• Blurred vision  

• Faintness  

• Loss of strength  

• Unusual bleeding  

• Weight loss  

• Trouble sleeping  

• Acute renal failure  

• Indigestion  

• Shortness of breath  

• Mouth sores  

• Anxiety  

• Dehydration  

• Nasal congestion  

Note - Immediately contact your doctor or medical practitioner if any side effects occur. 

Dosage 

Take this injection as prescribed by your doctor. The injection is given as an infusion into your vein by a doctor or nurse. Do not self administer.  

Missed dose  

• It is advisable not to miss a dose. If you miss an appointment for a scheduled dose of Zoltero injection, contact your doctor immediately.  

Overdose  

• In case of an overdose of Zoltero injection, the doctor will provide emergency medical treatment.  

Warnings 

Before starting treatment with Zoltero medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.  

•  Contraception  

• Use suitable methods of contraception to prevent pregnancy while taking this medicine.  

• Children and adolescents  

•  Zoltero injection is not advisable for use in children. 

Warnings for female  

• Pregnancy 

• Do not use this medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy.  

• Breastfeeding 

• This medicine is not recommended in breastfeeding unless it is essential. Please consult with your doctor before starting treatment with this medication. 

Precautions 

• Zoltero injection may cause severe joint and muscle pain.  

• This medicine may increase the risk of thigh and hip bone fracture.  

• The risk of osteonecrosis of the jaw is more in patients undergoing an invasive dental procedure.  

• Inform your doctor if you experience any side effects like - diarrhea, nausea, constipation, anemia, irregular heartbeat.  

• Zoltero injection may cause weakness, dizziness, and drowsiness in some patients.  

Cautions  

• Do not drive or operate heavy machinery. 

• Do not self administer.  

• Not safe for pregnant women.  

• Do not breastfeed while receiving this medication. 

Q1. What is Zoltero (Zoledronic Acid 4mg Injection)? 

Ans. It is used in the treatment of osteoporosis (weakening of the bones) caused by menopause or the use of steroids. 

Q2. How to take this injection?  

Ans. It is given as an infusion into the vein. Do not self administer this medicine.  

Q3. What are the side effects?  

Ans. Some common side effects are:- fatigue, constipation, nausea, sore throat, bone pain, vomiting, difficulty in swallowing, etc.  

Q4. In what strength is it available? 

Ans. This medicine is available in the strength of 4mg.  

Q5. Can I drive after taking this medicine?  

Ans. This medicine may affect your vision and your ability to concentrate.  

Q6. How does Zoltero injection work?  

Ans. This medicine works by suppressing the activity of osteoclasts (cells that destroy bones). 

Q7. What should I avoid while receiving this medication?  

Ans. Follow your doctor’s advice about any restrictions on food and other activities. 

Q8. What happens if I miss a dose?  

Ans. If you miss a scheduled dose of Zoltero injection, contact your doctor immediately. 

Q9. Can I consume alcohol while receiving this medicine?  

Ans. Please consult your doctor before consuming alcohol.  

Q10. Can I take this medicine during pregnancy?  

Ans. This medicine is not recommended during pregnancy.  

Q11. Does this medicine affect liver function?  

Ans. Please consult your doctor before consuming this drug. 

Q12. What are the self-care tips?  

Ans. Keep yourself hydrated and maintain good nutrition.  

Q13. What are the storage conditions?  

Ans. Store this medicine at room temperature.  

Q14. Can I take this medicine during breastfeeding?  

Ans. This medicine is not recommended in breastfeeding unless it is necessary.  

Interactions  

Zoltero injection can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.  

Medicine Interactions  

• Deferasirox  

• Iodamide  

• Tenofovir  

• Etelcalcetide  

• Cidofovir  

• Metrizamide  

Disease Interactions  

• Hypocalcemia  

• Kidney Impairment  

• Osteonecrosis of the jaw  

• Asthma  

Alcohol Interaction  

• Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.  

Contraindications 

• Do not take this medicine if you are allergic to Zoledronic. 

•  Zoltero (Zoledronic) medicine is not recommended in patients known to be hypersensitive. 

Substitutes 

• Zoldria  

• Blaztere 

• Zometa  

• Dasacine

• Cometriq

Reference

• zoledronic acid: Drugs information and usage are available at: - https://go.drugbank.com/drugs/DB00399, https://www.mayoclinic.org/drugs-supplements/zoledronic-acid-intravenous-route/description/drg-20066951, and https://www.drugs.com/mtm/zoledronic-acid.html.

zoledronic acid: Mechanism, side effects, and dosage are available at: - https://www.cancerresearchuk.org/about-cancer/treatment/drugs/zoledronic-acid, https://www.webmd.com/drugs/2/drug-21754/zoledronic-acid-intravenous/details, and https://medlineplus.gov/druginfo/meds/a605023.html.