Usage of Paxlovid Tablet
Paxlovid is an antiviral therapy that has two separate medication formulation which is packed together. The first medication is nirmatrelvir, which inhibits a key enzyme that the COVID virus requires in order to make functional virus particles. The second medication is ritonavir, which shuts down nirmatrelvir’s metabolism in the liver, so that it doesn’t move out of your body as quickly, allowing it to work longer. Together, these two medications are highly effective in fighting the COVID infection.
Pharmacodynamics of Paxlovid Tablet
Nirmatrelvir is a great way to inhibit the SARS-CoV-2 main protease (Mpro). Mpro is responsible for processing polyprotein precursors, and by inhibiting it, we can prevent viral replication. Ritonavir is a fantastic pharmacokinetic enhancer that helps increase nirmatrelvir plasma concentrations. Not to mention, it has no activity against SARS-CoV-2 Mpro. Together, these two drugs make a great team against the virus!
Side Effects from Paxlovid Tablet are:
The side effects of paxlovid are :
- Muscle aches
- Abdominal pain
- Throat tightness
- Skin rash
- Increased blood pressure
Trouble swallowing and breathing
Dosage of paxlovid
Paxlovid is a two-drug oral antiviral regimen consisting of nirmatrelvir and ritonavir, indicated for the treatment of COVID-19 in adults who do not require supplemental oxygen and who are at an increased risk of progression to severe disease.3
The recommended dosage of Paxlovid is two 150 mg tablets of nirmatrelvir plus 100 mg of ritonavir taken together twice daily for 5 days. Treatment must start quickly after a positive case of SARS-CoV-2 test and within symptom onset of 5 days. If a patient requires hospitalization due to severe or critical COVID-19 after starting treatment with Paxlovid, the patient should complete the entire 5-day treatment course at the healthcare provider’s discretion.
Paxlovid is a safe and effective treatment for patients with mild renal impairment. There is no need to adjust the dosage for these patients. For patients with moderate renal impairment, the recommended dosage of Paxlovid is 150 mg nirmatrelvir and 100 mg ritonavir twice daily for 5 days. At this time, Paxlovid is not recommended for use in patients with severe renal impairment.
Interactions of this drug with other medications
Paxlovid can increase the plasma concentrations of drugs that are primarily metabolized by CYP3A. Therefore, it's contraindicated to co-administer Paxlovid with other drugs that are highly dependent on CYP3A for clearance. This is because doing so could result in serious and/or life-threatening events. Additionally, you may need to adjust the dose or monitor closely when co-administering Paxlovid with other CYP3A substrates.
Nirmatrelvir and ritonavir are those forms of CYP3A substrates; therefore, these drugs that induce or stimulate CYP3A may decrease nirmatrelvir and ritonavir plasma levels in concentrations and reduce the therapeutic effect of paxlovid
It's important to speak with your doctor before taking this medication, especially if you have allergies. This product may contain inactive ingredients that can cause allergic reactions or other problems. There is limited information available about how this medication may affect other medical conditions, or how other medical conditions may affect how this medication works.
Be sure to tell your doctor or pharmacist about your medical history, especially if you have kidney or liver disease, or HIV infection. It's also important to continue taking precautions against spreading the virus, such as self-isolation, wearing a mask, social distancing, and washing hands.
If you are pregnant or think you might be pregnant, tell your doctor. The benefits of taking this medication during pregnancy should outweigh the potential risks. It's not clear if nirmatrelvir passes into breast milk. However, we do know that ritonavir does pass into breast milk. If you're infected with COVID-19 and considering breastfeeding, you should speak with your doctor about the risks involved with using this product.
Frequently Asked Questions
1. Who cannot take Paxlovid Tablet?
Individuals suffering from severe liver disease cannot take paxlovid.
2. Will paxlovid make me feel better?
Paxlovid showed improved signs of covid 19 improved symptoms within a day or two.
3. Can Paxlovid Tablet make you feel worse?
Paxlovid can sometimes show signs of changes in taste, high blood pressure, and abdominal pain in certain patients.
4. Do I have to quarantine after taking Paxlovid Tablet?
Patients should isolate for a maximum of 5 days after taking paxlovid.
5. Does paxlovid work on omicron?
Yes, paxlovid works on omicron where it reduced the risk of hospitals or deaths by as much as 44%.
6. Can I take multivitamins with Paxlovid Tablet?
The usage of multivitamins should be avoided as it can impact the reactivity and efficiency of paxlovid action in the body.
7. What type of medication is Paxlovid Tablet?
Paxlovid is a combined type of medications which is approved for the use of covid 19 treatment.