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Aprazer
21 Capsule in Box
Palbociclib
Keep in Cold Place
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Overview
Palbociclib 125mg capsules are used in the treatment of breast cancer. Patients with certain breast cancer (human epidermal growth factor receptor 2-negative and estrogen receptor-positive) can also be treated with Palbociclib 125mg capsules. This medicine belongs to a group of cancer-fighting medications called protein kinase inhibitors. It works by blocking the action of chemicals that cause cancer cells to divide and grow. Palbociclib 125mg capsules are used in combination with another medicine, like fulvestrant, in patients with disease progression following endocrine therapy and an aromatase inhibitor (such as anastrozole, exemestane, or letrozole) as initial endocrine-based therapy in postmenopausal women or in men. Close monitoring of blood cell count is necessary while having treatment with this medicine.
Breast Cancer, Metastatic Cancer
Treatment of Breast Cancer
The human body reacts differently to Palbociclib 125mg capsules. Response or undesired symptoms vary from individual to individual. Usually, they disappear with time as the body adjusts to the medicine; these side effects don't need special medical attention. Whereas if the symptoms don't disappear with time or you have severe side effects, then consult your doctor immediately. Some of the common side effects of Palbociclib 125mg capsules are mentioned below:
Blurred vision
Loss of appetite
Sore throat
Bleeding gums
Difficulty in breathing
Back pain
Pale skin
Unusual tiredness
Chest pain
Red spots on the skin
Inflammation of the mouth
Fever
Rashes
Change in taste
Take the dose of Palbociclib 125mg capsules as per your healthcare provider’s prescription. Do not stop taking the medicine suddenly, unless your doctor tells you. This medicine is given under the strict supervision of a doctor. Do not self-administer. Overdose is a very unusual state for this medicine because it is given under the supervision of a healthcare provider. Palbociclib 125mg capsules can be taken without food or with food. The doctor will provide emergency medical treatment. You should not break, crush, or chew the medicine; it should be swallowed as a whole.
Palbociclib 125mg capsules, an anticancer medicine, work by inhibiting cyclin-dependent kinase 4 and 6; as a result, cell growth ceases or stops, arresting the cancer cell cycle. Cyclin-dependent kinase 4 and 6 (chemical messengers) play an essential role in downstream signaling pathways, which lead to the proliferation of cells. It also disrupts the cell cycle by targeting estrogen (hormone) receptor-positive breast cancer cells.
Alcohol
unsafe
The interaction of alcohol with this drug is still unknown. It is advisable not to consume alcohol while taking Palbociclib 125mg capsules. Consult your doctor for further information.
Pregnancy
consult your doctor
Palbociclib 125mg capsules may be considered unsafe during pregnancy. Please consult your doctor in such a condition. According to some research data, taking Palbociclib 125mg capsules during pregnancy has shown harmful effects on the developing baby.
Breast Feeding
consult your doctor
Palbociclib 125mg capsules are probably not safe if you're breastfeeding. Kindly consult your doctor before taking Palbociclib 125mg capsules while breastfeeding, as there are chances that it may pass to the developing baby through the breast milk of the mother.
Driving
danger
It is advisable not to drive or operate heavy machinery after taking Palbociclib 125mg capsules, as you may feel dizzy.
Kidney
precaution
Share your medical history with your healthcare expert in case of kidney disease before taking Palbociclib 125mg capsules. Patients with renal impairment must be careful while taking Palbociclib 125mg capsules. They may require adjustment in the dose.
Liver
precaution
Inform your doctor before starting Palbociclib 125mg capsules if you have liver disease to avoid any serious side effects. Patients with hepatic impairment must be careful while taking Palbociclib 125mg capsules. They may require adjustment in the dose.
It is an anti-cancer medication used in the treatment of breast cancer.
It works by blocking the action of chemicals that cause cancer cells to divide and grow.
Some common side effects of Palbociclib 125mg Capsule are inflammation of the mouth, fever, rashes, pale skin, sore throat, and blurred vision.
This medicine is not recommended during pregnancy as it may harm newborn babies
Please consult your doctor before consuming this drug.
If you take extra doses of Palbociclib 125mg capsules, then you should immediately go to the hospital emergency room or call your healthcare provider right away.
Store Palbociclib 125mg capsules at 68 °F to 77 °F (20 °C to 25 °C) in the original blister pack. Keep out of the reach of children.
Consult your doctor before taking any supplements or vitamins to prevent any kind of interactions with Palbociclib 125mg capsules, which can cause severe effects to the individual.
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Fry DW, Harvey PJ, Keller PR et al. (2023). Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 2004; 3: 1427–38.
Marzec M, Kasprzycka M, Lai R et al. (2025). Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity. Blood 2006; 108: 1744–50.
Finn RS, Dering J, Conklin D et al. (2024). PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 11: R77.
Finn RS, Crown JP, Lang I et al. (2023). The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol . 16: 25–35.
Xiao H, Sooryanarayana V, Sarah A. A, Brooke B. B, Shuko H, Shi W, Gene P. S, Katia K, Ceren Y. (2023). A Genomic Alteration in GATA3 Affects Treatment Responses With a CDK4/6 Inhibitor Collaborating With p18INK4C Expression in Advanced Breast Carcinoma, Modern Pathology, 38, 12, (100841).
Karasic TB, O'Hara MH, Teitelbaum UR, Damjanov N, Giantonio BJ, d'Entremont TS, Gallagher M, Zhang PJ, O'Dwyer PJ. (2024). Phase II Trial of Palbociclib in Patients with Advanced Esophageal or Gastric Cancer. Oncologist. 25(12):e1864-e1868.
Aprazer
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