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Zejula 100mg Capsule

Zejula 100mg Capsule

Salt Composition: Niraparib

Expiry Date: 01/2028

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90 capsule

About The Product

Ovarian Cancer

Niraparib 100mg capsule is prescribed by doctors to cure cervical cancer in women. Its generic name is Niraparib.

Description

Zejula 100mg Capsule contains Niraparib as an active ingredient. This anticancer medicine belongs to the class of drugs known as PARP (poly ADP-ribose polymerase) inhibitors. It is prescribed to treat certain types of cancers, primarily ovarian, fallopian tube, and peritoneal cancers.

Also It can be used to treat certain types of cancer in people with specific gene (BRCA) changes. It works by inhibiting the action of PARP enzyme that repairs damaged DNA in the cancer cells, resulting in their death.

Close monitoring of blood cell count is necessary while having treatment with this medicine. Take it in the exact dosage prescribed by the doctor.

Uses

  • Ovarian cancer

  • Fallopian tube cancer

  • Primary peritoneal cancer

Side Effects

The human body reacts differently to Zejula 100mg Capsule. Response or undesired symptoms vary from individual to individual. Usually, they disappear with time as the body adjusts to the medicine; these side effects don't need special medical attention. Whereas if the symptoms don't disappear with time or you have severe side effects, then consult your doctor immediately. Some of the common side effects of Capsule are mentioned below:

  • Nausea and vomiting

  • Fatigue

  • Loss of appetite

  • Constipation

  • Insomnia

  • Stomach pain

  • Headache or dizziness

Serious:

  • Severe anaemia

  • Thrombocytopenia

  • Hypertension

  • Allergic reactions

  • Bone marrow suppression

  • Rare cases of myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML)  

How To Use

  • Take Zejula 100mg Capsule in exact dose as prescribed by the doctor.
  • The typical dose of this capsule varies with age and overall health factor of the patient.
  • It can be taken with or without food but at a fixed time each day to get better results.
  • Niraparib capsule should be swallowed as a whole with water without crushing, chewing, or opening the capsule.
  • Don't miss a dose or overdose the medicine.

How It Works

Zejula 100mg Capsule contains Rucaparib as an active ingredient. This anticancer medicine belongs to the class of drugs known as PARP (poly ADP-ribose polymerase) inhibitors.

This tablet is an inhibitor of poly Adenosine diphosphate-ribose polymerase enzymes, including PARP-1, PARP-2, and PARP-3, that play a vital role in DNA repair. Niraparib 100mg capsule works by inhibiting the action of specific enzyme that repairs damaged DNA in the cancer cells, resulting in their death.

Safety Advice

Alcohol
Avoid the consumption of alcohol while taking Zejula 100mg Capsule, as alcohol can decrease the effectiveness of the medicine as well as worsen the symptoms.
Pregnancy
Do not take Zejula 100mg Capsule without consulting the doctor in case of pregnancy, as it can be unsafe to take it during this period.
Breast Feeding
Breastfeeding women should discuss the potential risks and benefits of the Zejula 100mg Capsule with their healthcare provider before starting treatment.
Driving
Zejula 100mg Capsule may cause side effects such as dizziness or lack of concentration, which could affect your ability to drive. So it's better to avoid driving.
Kidney
Share your medical history with the doctor before starting the Zejula 100mg Capsule. Do not take it without consulting a doctor if you have any kidney related issue.
Liver
Share your medical history with the doctor before starting the Zejula 100mg Capsule. Do not take it without consulting a doctor if you have any liver related issue.

Missed Doses

  • ​ It is advisable not to miss any dose.
  • In case you miss a dose of Niraparib 100mg capsule consult your doctor soon.
  • Missing the dose will impact the overall health of the patients.
  • So, it is always advisable to follow the prescription of the doctor strictly.

FAQs

Zejula 100mg Capsule is an anti-cancer medication used to treat certain types of cancer such as ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

References

  • Moore, K. N., Secord, A. A., Geller, M. A., Miller, D. S., Cloven, N., Fleming, G. F., ... & Monk, B. J. (2019). Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial. The Lancet Oncology, 20(5), 636-648. https://pubmed.ncbi.nlm.nih.gov/30948273/

  • Li, N., Zhu, J., Yin, R., Wang, J., Pan, L., Kong, B., ... & Wu, L. (2023). Treatment with niraparib maintenance therapy in patients with newly diagnosed advanced ovarian cancer: a phase 3 randomized clinical trial. JAMA oncology, 9(9), 1230-1237. https://pubmed.ncbi.nlm.nih.gov/37440217/

  • González-Martín, A., Pothuri, B., Vergote, I., DePont Christensen, R., Graybill, W., Mirza, M. R., ... & Monk, B. J. (2019). Niraparib in patients with newly diagnosed advanced ovarian cancer. New England Journal of Medicine, 381(25), 2391-2402. https://pubmed.ncbi.nlm.nih.gov/31562799/

  • Mirza, M. R., Monk, B. J., Herrstedt, J., Oza, A. M., Mahner, S., Redondo, A., ... & Matulonis, U. A. (2016). Niraparib maintenance therapy in platinum-sensitive, recurrent ovarian cancer. New England Journal of Medicine, 375(22), 2154-2164.

  • Scott, L. J. (2017). Niraparib: first global approval. Drugs, 77(9), 1029-1034. https://pubmed.ncbi.nlm.nih.gov/28474297/

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