AVASTIN

Mfd. by :- Roche (Fulfilled By : Magicine Pharma)

Avastin

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name:- Avastin 

Generic Name:- Bevacizumab

Manufacturer:- Roche

Dosage form:- Injection 

Strength:- 100mg/4ml

Composition:- Bevacizumab

Packaging:- 1vial

Indication:- Colorectal cancer

Storage:- Store in a refrigerator 

Overview

Avastin (Bevacizumab) injection is an anticancer medicine. It is used in the treatment of certain types of cancers such as colorectal, cervical, ovarian, non-small cell lung cancer, kidney cancer, and brain tumor. This medication helps to stop the growth of tumors. This medicine is given in the form of an injection by your doctor or nurse. Your doctor will decide the dosing schedule according to your medical condition and your response to the treatment. Do not take this medicine in the wrong way as it may lead to some severe side effects. Inform your medical advisor if you are using any other medications. 

Bevacizumab is an anti-VEGF (Vascular endothelial growth factor) medication, which is beneficial in the treatment of certain types of cancers; it has also been suggested that Bevacizumab is a promising and useful drug to treat patients with severe and critical COVID-19.

Pharmacodynamics of Avastin (Bevacizumab)

Avastin binds vascular endothelial growth factor (VEGF)and prevents the interaction of VEGF to its receptors on the surface of endothelial cells. The interaction of VEGF with its receptors leads to endothelial cell proliferation and new blood vessel formation in in-vitro models of angiogenesis. 

Advantages of Avastin (Bevacizumab) 

  • Avastin injection treats and lowers the risk of developing cancerous cells and colorectal cancer. 

  • This medicine may be given alone or in combination with other medications to treat non-small cell lung cancer. 

  • This is an anti-cancer medicine that is used to kill the cancerous cell in cervical cancer.

Substitutes of Avastin (Bevacizumab)

  • Bevatas 

  • Krabeva 

  • Advamab 

  • Zybev

Side effects of Avastin (Bevacizumab)

This medicine may cause some serious and unwanted side effects. Which requires immediate medical attention otherwise it can also lead to higher risk. Do not forget to discuss the risk and benefits of this medication with your doctor.

Common side effects 

  • Bleeding gums 

  • Chest pain 

  • Sore throat 

  • Fever 

  • Dizziness 

  • Irregular heartbeat 

  • Loss of appetite 

  • Body pain 

  • Runny nose 

  • Vomiting 

  • Diarrhea 

  • Seizures 

  • Unusual bleeding 

  • High blood pressure 

  • Nose bleeds 

  • Dry skin 

  • Swelling of the feet, fingers, lower legs. 

  • Protein in urine 

  • Taste change 

  • Cough

  • Shortness of breath 

  • Fatigue 

  • Nasal congestion 

  • Pale skin

  • Headache 

  • Hypertension 

  • Blood clots 

Note- If any of these symptoms occur, contact your doctor 

 

Dosage

Take this injection as prescribed by your doctor. Do not take this medicine in the wrong way and make sure to take this injection according to your dosing schedule. 

Missed dose 

  • This medication is given by your doctor or nurse. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately. 

Overdose 

  • This medication is given by your doctor or nurse. In case of an overdose, your doctor will provide emergency medical treatment. 

Usage of Avastin (Bevacizumab) 

This is a cancer medicine that interferes with the growth and spread of cancer cells in the body. It is also used to treat cancer of the membrane lining. This medicine is used alone or in combinations with other medicines. Take this medicine according to your medical advisor and do not self administer this injection. Consult your doctor immediately if you experience any symptoms during treatment with this medicine. This medication may take some time to show results. Do not stop taking this medicine unless your medical advisor told you to do so. Avastin injection is given once every 2 or 3 weeks.

Warnings

Before starting treatment with Avastin, please tell your doctor about your previous medical history. If you experience any symptoms while receiving this medicine do not ignore those symptoms because it may lead to a higher risk. 

  •  Contraception 

    • Use effective methods of contraception to prevent pregnancy while taking this medicine. 

  • Children and adolescents 

    • This medicine is not advisable for use in children and adolescents. 

Warnings for female 

  • Pregnancy 

    • Avastin shouldn’t be used by women who are pregnant. Atezolizumab may harm the baby. It is recommended that this medication should be avoided during pregnancy. 

  • Breastfeeding 

    • This medicine is not recommended for use in breastfeeding women unless it is necessary. Please consult your medical advisor before starting treatment with this medicine. 

General warning and precaution

  • This medicine may cause dizziness or fainting and it may affect your ability to drive. 

  • This medicine may cause severe bleeding disorders and gastrointestinal perforation. 

  • This medication may delay wound healing. 

  • Close monitoring of heart function is required. 

  • The use of this medicine may cause fetal harm. 

Cautions 

  • Do not drive or operate heavy machinery. 

  • Not safe for pregnant women. 

  • Do not self - administer this medicine. 

  • Do not breastfeed while taking this medication. 

Q1. What is Avastin (Bevacizumab)? 
Ans. This infusion is used to treat a certain type of brain tumor and cancer of the kidney, colorectal, lung, ovarian, etc.   
Q2. How does this medication work? 
Ans. Avastin injection works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels.  
Q3. What are the side effects? 
Ans. Some common side effects are:- chest pain, sore throat, dizziness, severe bleeding, high blood pressure, kidney or heart problems, loss of appetite, body pain, etc. 
Q4. How is Avastin given? 
Ans. This medicine is given in the form of an injection which is given by your doctor or nurse. This medication is usually given once every 2 or 3 weeks. 
Q5. What should I avoid while receiving this medicine? 
Ans. Follow your doctor’s instructions about any restrictions.  
Q6. How long does it take this medicine to show effect? 
Ans. After the administration, the effect of this medicine can be observed immediately. 
Q7. In what strength is it available? 
Ans. It is available in the strength of 100mg/4ml. 
Q8. What happens if I miss a dose? 
Ans. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately. 
Q9. Does this affect liver function? 
Ans. Please consult your medical condition with your doctor before consuming this drug. 
Q10. Can I consume alcohol while taking this medicine? 
Ans. It is not known whether it is safe or not. Please consult your doctor before consuming alcohol. 
Q11. Can I drive after taking this medicine? 
Ans. This medicine may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur. 
Q12. Can I take this medicine during pregnancy? 
Ans. This medicine is not recommended for pregnant women. 
Q13. Can I take this medicine during breastfeeding? 
Ans. This medicine is not recommended for use in breastfeeding women unless it is necessary.
Q14. What are the storage conditions? 
Ans. Store this medicine in the refrigerator. Do not freeze or shake the medicine.

Interactions

Interactions may change how your medication works and increase the risk for side effects. Don’t forget to disclose your previous medical history with your doctor. 

Medicine interaction 

  • Deferiprone 

  • Palifermin 

  • Sunitinib 

  • Topotecan 

  • Pamidronate 

  • Risedronate 

Disease interaction 

  • Gastrointestinal perforation 

  • Bleeding 

  • Hypertension 

  • Proteinuria

Alcohol interaction 

  • Interaction with alcohol is unknown, please consult your doctor before consuming alcohol. 

 

Contraindications 

  • Avastin injection is not recommended for use in patients with a known allergy to Bevacizumab. 

  • This medicine is contracted in patients with known hypersensitivity to Bevacizumab.

  • This medicine is not recommended in patients with bleeding disorders. 

  • Avastin injection should not be used until surgical wounds are fully recovered.

Above Content has been reviewed by Professionals