Lederla Leucovorin 10mg Injection

• Prevention of Harmful effects of methotrexate

Lederle Leucovorin 10mg/2ml Injection is prescribed to minimize the effect of anticancer medication, but this drug can also leads to some undesired symptoms. Usually, they disappear with time as the body adjusts to the medicine. These side effects don't need special medical attention. It is advised to consult your doctor if these symptoms become unmanageable.

Some common side effects include:

• Fatigue
• Diarrhea               
• Seizures
• Dizziness
• Sore mouth
• Skin inflammation
• Nausea
• Vomiting
• Difficulty breathing
• Swallowing
• Pain, swelling, and redness at the injection site

Seek medical attention in case of any unusual or severe side effects immediately

• Lederle Leucovorin 10mg/2ml Injection is a prescription-based drug. It is advised to take this injection after consulting your healthcare expert.
• This medicine should be given intravenously by an experienced nurse or doctor. Please do not self-administer.
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• Lederle Leucovorin 10mg/2ml Injection is prescription based medicine that belongs to the drug class of folic acid antagonists. This injection is a constituent form of Vit B12. It inhibits the activity of dihydrofolate reductase enzyme to prevent the side effects of methotrexate.
• This injection also protects normal healthy cells from toxicity of methotrexate and increases therapeutic effects to kill the cancer cells in colorectal cancer. Lederle Leucovorin also supply folic acid to bone marrow that supports the formulation of red blood cell and eventually treats anemia.
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It is advised to take Lederle Leucovorin 10mg/2ml Injection 24 hours after the anticancer drug.

• Share with your doctor if you're intolerant to some sugar, as Lederle Leucovorin contains a sugar constituent.
• Avoid taking Lederle Leucovorin 10mg/2ml Injection if you are allergic to Leucovorin calcium and its constituents.
• It is advised to take consultation with your doctor if you are suffering from Vit B12 deficiency or certain type of anemia.
• It is advised to use effective birth control methods and avoid pregnancy during the treatment with Leucovorin 10mg/2ml Injection.
• Share with your healthcare expert if you're taking any anti-seizure medication. They may interact with the Lederle Leucovorin Injection and may lead to severe side effects.
• If you experience any kind of symptoms after taking Leucovorin 10mg/2ml Injection, like trouble breathing, skin rash, or swelling in the lips, face, or tongue, it is important to inform your doctor as soon as possible.​​
  

• Madajewicz, S., Petrelli, N., Rustum, Y. M., Campbell, J., Herrera, L., Mittelman, A., ... & Creaven, P. J. (1984). Phase I-II trial of high-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer. Cancer research, 44(10), 4667-4669.
• Mullin, R. J., Keith, B. R., & Duch, D. S. (2012). Distribution and metabolism of calcium leucovorin in normal and tumor tissue. In The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy (pp. 25-38). New York, NY: Springer US.
• Trissel FASHP, L. A., Martinez, J. F., & Xu, Q. A. (1995). Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium. American journal of health-system pharmacy, 52(7), 710-715.
• Schilsky, R. L., & Ratain, M. J. (1990). Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration. JNCI: Journal of the National Cancer Institute, 82(17), 1411-1415.
• Pont, L. O., Cheung, A. P., & Lim, P. (1979). Calcium leucovorin. In Analytical profiles of drug substances (Vol. 8, pp. 315-350). Academic press.