Leutero 50mg Injection

• Prevention of Harmful effects of methotrexate

Leutero 50mg/5ml Injection is prescribed to minimize the effect of anticancer medication, but this drug can also leads to some undesired symptoms. Usually, they disappear with time as the body adjusts to the medicine. These side effects don't need special medical attention. It is advised to consult your doctor if these symptoms become unmanageable.

Some of the common side effects of Leutero Injection are mentioned below:

• Fatigue
• Diarrhea
• Seizures
• Dizziness
• Sore mouth
• Skin inflammation
• Nausea and vomiting
• Difficulty breathing or swallowing
• Pain, swelling, and redness at injection site

• Leutero 50mg/5ml Injection is a prescription-based drug. It is advised to take this injection after consulting your healthcare expert. T
• his medicine should be given intravenously by an experienced nurse or doctor. Please do not self-administer.​
  

• Leutero 50mg/5ml Injection is prescription based medicine that belongs to the drug class of folic acid antagonists. This injection is a constituent form of Vit B12. It inhibits the activity of dihydrofolate reductase enzyme to prevent the side effects of methotrexate.
• This injection also protects normal healthy cells from toxicity of methotrexate and increases therapeutic effects to kill the cancer cells in colorectal cancer. It also supply folic acid to bone marrow that supports the formulation of red blood cell and eventually treats anemia.
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• It is advised not to miss any scheduled dosage of Leutero 50mg/5ml Injection. In case you miss a dose, consult your doctor immediately.
• Don't overdose to compensate for the missed one. Contact your doctor or any healthcare provider and seek medical attention immediately in such cases.​
  

• It is advised to take Leutero 50mg/5ml Injection 24 hours after the anticancer drug.
• Share with your doctor if you're intolerant to some sugar, as Leutero Injection contains a sugar constituent.
• Avoid taking Leutero 50mg/5ml Injection if you are allergic to Leucovorin calcium and its constituents.
• It is advised to take consultation with your doctor if you are suffering from Vit B12 deficiency or certain type of anemia.
• It is advised to use effective birth control methods and avoid pregnancy during the treatment with Leutero 50mg/5ml Injection.
• Share with your healthcare expert if you're taking any anti-seizure medication. They may interact with Leutero and may lead to severe side effects.
• If you experience any kind of symptoms after taking Leutero Injection, like trouble breathing, skin rash, or swelling in the lips, face, or tongue, it is important to inform your doctor as soon as possible.​​
  

• Pont, L. O., Cheung, A. P., & Lim, P. (1979). Calcium leucovorin. In Analytical profiles of drug substances (Vol. 8, pp. 315-350). Academic press. https://librarysearch.le.ac.uk/discovery/fulldisplay?vid=44UOLE_INST%3AVE&docid=alma991010100349702746&context=L
• Schilsky, R. L., & Ratain, M. J. (1990). Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration. JNCI: Journal of the National Cancer Institute, 82(17), 1411-1415. https://pubmed.ncbi.nlm.nih.gov/2388292/
• Archie Bleyer, W. (1989). New vistas for leucovorin in cancer chemotherapy. Cancer, 63(S6), 995-1007. https://pubmed.ncbi.nlm.nih.gov/2645044/
• Cercós-Fortea, T., Casabó, V. G., Nacher, A., Cejudo-Ferragud, E., Polache, A., & Merino, M. (1997). Evidence of competitive inhibition of methotrexate absorption by leucovorin calcium in rat small intestine. International journal of pharmaceutics, 155(1), 109-119. https://www.sciencedirect.com/science/article/abs/pii/S037851739700152X
• Margolin, K. A., Doroshow, J. H., Akman, S. A., Leong, L. A., Morgan, R. J., Raschko, J. W., ... & Blevins, C. (1992). Effective initial therapy of advanced breast cancer with fluorouracil and high-dose, continuous infusion calcium leucovorin. Journal of clinical oncology, 10(8), 1278-1283.https://pubmed.ncbi.nlm.nih.gov/1634917/​