Dacoplice 15mg Tablet

Dacoplice 15mg Tablet is a chemical based targeted anti cancer medication. Like any other chemotherapeutic drug, it also has multiple side effects that range from common to extreme. Consult your doctor, if symptoms persists for longer period of time or if you experience any of the serious side effects.
● Vomiting
● Nausea
● Fatigue
● Diarrhea
● Decreased Appetite
● Abdominal Pain
● Dry Skin
● Nail Inflammation
● Mouth Sores
● Constipation
● Rashes
● Weight Loss
● Headache
● Arthralgia
● Dyspnea
● Gastrointestinal Perforation
● Liver Toxicity
● Kidney Issues
● Pneumonitis
● Visionm Related Issues

Dacoplice 15mg Tablet is generally used for first dose reduction for adverse reactions.This medicine is taken orally as whole on an empty stomach, without breaking, biting or chewing. Consult your doctor for exact dosage that is especially meant for you.

Dacoplice 15mg Tablet contains Dacomitinib that belongs to irreversible pan-HER tyrosine kinase inhibitor class. It covalently binds to Cysteine residues in kinase domains EGFR. As a result, blocking their activation and downstream signalling pathways like RAS-RAF-MEK-ERK and PI3K-AKT. This stops ligand-induced receptor dimerization, autophosphorylation, and signaling cascades that cause EGFR-mutated NSCLC cells to proliferate uncontrollably.

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• Wu, Y. L., Cheng, Y., Zhou, X., Lee, K. H., Nakagawa, K., Niho, S., ... & Mok, T. S. (2017). Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial. The Lancet Oncology, 18(11), 1454-1466.
• Cheng, W. C., Lin, C. C., Liao, W. C., Lin, Y. C., Chen, C. H., Chen, H. J., ... & Hsia, T. C. (2024). The difference between dacomitinib and afatinib in effectiveness and safety in first-line treatment of patients with advanced EGFR-mutant non-small cell lung cancer: a real-world observational study. BMC cancer, 24(1), 228.
• Reed, J. E., & Smaill, J. B. (2016). The discovery of dacomitinib, a potent irreversible EGFR inhibitor. In Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1 (pp. 207-233). American Chemical Society.