Brand name- Geftinat
Manufacturer- NATCO Pharma Ltd.
Dosage form- Tablet
Route of Administration- oral
Indication- non-small cell lung cancer (NSCLC).
Storage- Store at room temperature (10-30°C)
Class of drug- Anti-Neoplastics
Mechanism of Action
It works by blocking the action of abnormal protein that signals cancer cells to multiply. This in turn helps to slow or inhibit the spread of cancer cells
The most common side effects of geftinat include nausea, rash, vomiting and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult the doctor if it happens. It makes the patient sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out.
It is study of drug effects and what the medicine does to the body
It inhibits the intracellular phosphorylation of tyrosine kinase associated with epidermal growth factor (EGFR).
Study of what body does to the medicine.Geftinat is absorbed slowly after oral administration as it has bioavailability of 60%. Elimination is through metabolism (primarily CYP 3A4) and excretion in feces.
Geftinat is slowly absorbed, with peak plasma levels in 3-7 hours after dosing and mean oral bioavailability of 60%
Shelf life is the time period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at time of manufacture.
Its shelf life is 26 months
Which disease area
non-small cell lung cancer (NSCLC)
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Consult your doctor before taking this medicine, if you:
Experience unexplained shortness of breath, cough, and fever that comes on suddenly. These could be symptoms of a serious lung condition.
Have severe or continuing diarrhea that lasts up to 14 days.
Experiencing adverse skin reactions like blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin
Common side effects
Allergic skin reaction
Nausea and Vomiting
Serious side effects
Unusual bleeding (in cough and urine),eye irritation or pain, or swelling of the ankles or feet
If the patient misses a dose of medicine, skip it and continue with the normal schedule. No need to double the dose
Get the emergency medical treatment and contact your physician
General warning and precautions
Do not take antacids (to reduce the acid level of your stomach) 2 hours before or 1 hour after administering geftinat.
Diarrhea can occur as a side effect. Drink plenty of fluids and inform the doctor in case if it doesn't stop or there is blood in stools.
It is usually taken on an empty stomach once a day, at least 1 hour before or 2 hours after eating a meal or snack. Take geftinat at around the same time every day.
Q What is Gaftinat
Geftinat 250 mg Tablet is an anticancer medicine used for the treatment of cancer of the lungs. Take the medicine under the supervision of a qualified physician. This medicine is not recommended for use in patients with lung and liver diseases
Q How Gaftinat works
Epidermal growth factor receptors (EGFR) are expressed on the lung cancer cell surfaces that regulate their growth. This medicine works by binding the chemical messenger, EGFR, thus inhibits the cancer signaling pathways. This is how the medicine inhibit further growth of the cancer cells.
Q What are the side effects
Side Effects of Gaftinat include nausea, rash, vomiting and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult the doctor if it happens. It makes the patient sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out.
Q In what strength it is available
It is available in 250mg
Q What should I avoid while receiving this medicine
Avoid grapejuice and smoking while taking the medication
Q How to use Giftinat
Giftinat 250mg Tablet is a pill to be administered orally, once a day without food as prescribed by the concerned specialist. Take Giftinat 250 mg Tablet empty stomach, at least 1 hour before or 2 house after meals. Take it the same time each day so that you remember when to take it
Q What happens when I miss a dose
If you miss a dose of medicine, skip it and continue with the normal schedule. No need to double the dose
Q Does this medicine effects liver function
There is no data available. Consult doctor before consuming the medicine.
Q Can I drive after taking this medicine
Do not drive if you have any symptoms that affect your ability to concentrate and react. Geftinat Tablet make you feel weak. This may affect your driving ability.
Q Can I take this medicine during pregnancy
Geftinat tablet is not safe to use during pregnancy as there is proven evidence of risk to the developing baby.
Q Can I take this medicine during breast-feeding
Geftinat tablet is probably not safe to use during breastfeeding.
Q Can I consume Alcohol while taking this medicine
It is not safe to consume Alcohol
Q Does it affect kidney functions
There is no affects on the kidney functions
Q What are the storage conditions
Store the medicine at room temperature (10-30°C)
Ranitidine, cimetidine, famotidine, omeprazole, lansoprazole, rabeprazole)
NSAIDs (such as ibuprofen, naproxen), corticosteroids
The drug is contraindicated in patients who have suffered or are suffering from glaucoma, cardiac disorders, lungs or liver disorders or renal malfunctioning
Alcohol may cause interactions, consult your doctor
The patient should also avoid grapefruit and grapefruit juice while taking the medicine. Take with or without food. The absorption is unaffected by food.