Gluformin 500 Tablet

• Type 2 diabetes mellitus
• Polycystic ovarian syndrome (PCOS)

Gluformin 500 Tablet may cause some side effects that vary from one patient to another. Most side effects do not require any medical attention and disappear as your body adjusts to the medicine.
Common side effects include:

• Diarrhea
• Headache
• Vomiting
• Nausea
• Abdominal discomfort

Seek medical attention in case of any unusual or severe side effects immediately.

• Take Gluformin 500 Tablet in dosage as prescribed by the doctor. Dosage and the duration determined as per the patients health condition.
• This tablet should be swallowed as a whole with water. Don't crush, chew, or break the tablet. It should be taken with food. Never skip a dose or double dose.
  
  

• Gluformin 500 Tablet is a biguanide-based anti-diabetic drug. It functions by minimizing the liver's synthesis of glucose, slowing the intestines' absorption of sugar (glucose), and enhancing the body's sensitivity to insulin.
• This tablet lowers insulin and androgen levels, improves insulin sensitivity, and promotes ovulation and regular menstruation in PCOS. Reducing insulin resistance can be helpful for both metabolic and reproductive symptoms, like acne, unwanted hair growth, weight, and diabetes risk.
  

• Pugeat, M., & Ducluzeau, P. H. (1999). Insulin resistance, polycystic ovary syndrome and metformin. Drugs, 58(Suppl 1), 41-46.   https://pubmed.ncbi.nlm.nih.gov/10576524/
• Graham, G. G., Punt, J., Arora, M., Day, R. O., Doogue, M. P., Duong, J., ... & Williams, K. M. (2011). Clinical pharmacokinetics of metformin. Clinical pharmacokinetics, 50(2), 81-98. https://pubmed.ncbi.nlm.nih.gov/21241070/
• Scarpello, J. H. (2001). Optimal dosing strategies for maximising the clinical response to metformin in type 2 diabetes. The British Journal of Diabetes & Vascular Disease, 1(1), 28-36. https://journals.sagepub.com/doi/10.1177/14746514010010010501
• Garber, A. J., Duncan, T. G., Goodman, A. M., Mills, D. J., & Rohlf, J. L. (1997). Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial. The American journal of medicine, 103(6), 491-497. https://pubmed.ncbi.nlm.nih.gov/9428832/
• Chae, Y. K., Arya, A., Malecek, M. K., Shin, D. S., Carneiro, B., Chandra, S., ... & Giles, F. (2016). Repurposing metformin for cancer treatment: current clinical studies. Oncotarget, 7(26), 40767. https://pubmed.ncbi.nlm.nih.gov/27004404/