Hepcinat Plus 60mg/400mg Tablet

Hepcinat Plus 60mg/400mg Tablet

Prescription requiredRx Required

Salt Composition: Sofosbuvir 400mg + Daclatasvir 60mg

Expiry Date: 01/2028

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Buy at $142.41

$142.41

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28 tablet

About The Product

Hepatitis C

Hepcinat Plus 60mg/400mg Tablet is an antiviral medication that is used in combination with other medicines. It is used in the treatment of chronic hepatitis C virus (HCV) infection. It stops or prevents the growth of viruses in the body and helps remove the virus from the blood. Hepcinat Plus 60mg/400mg Tablet helps you to recover faster and controls the infection from spreading in your body.

This is a prescription-based medicine, which is to be taken only when prescribed by your doctor. Usually taken once daily with or without food, the course of treatment lasts 12 to 24 weeks depending on the patient’s condition. While effective, it can cause side effects such as tiredness, headache, nausea, vomiting, fever, cough, trouble sleeping, changes in liver function, or allergic reactions.

Uses

Treatment of Chronic hepatitis C virus (HCV) infection

Side Effects

The human body reacts differently to Hepcinat Plus 60mg/400mg Tablet. Response or undesired symptoms vary from individual to individual. Usually, they disappear with time as the body adjusts to the medicine; these side effects don't need special medical attention. Whereas if the symptoms don't disappear with time or you have severe side effects, then consult your doctor immediately.

Some of the side effects of Hepcinat Plus 60mg/400mg Tablet are mentioned below:

  • Headache 
  • Fever
  • Chills
  • Nausea
  • Insomnia (difficulty in sleeping)
  • Diarrhea
  • Fatigue
  • Allergic Reactions (Skin rash, Itching, irritability, breathing difficulty)
  • Slow heart rate
  • Liver issues

Dosage and Administration

  • Take the dose of Hepcinat Plus 60mg/400mg Tablet as per your healthcare provider’s prescription.
  • Do not stop taking the medicine suddenly unless your doctor tells you to.
  • This medicine is given under the strict supervision of a doctor. Do not self-administer.
  • Hepcinat Plus 60mg/400mg Tablet can be taken without food or with food. 
  • You should not break, crush, or chew the medicine; it should be swallowed as a whole. 

Mechanism of action

  • Hepcinat Plus 60mg/400mg Tablet is made by combining two medicines that are Sofosbuvir and Daclatasvir.
  • They both lower the viral load in the body and the viruses in the blood. Daclatasvir inhibits a protein called NS5A, which is an important protein required for the replication of the hepatitis C virus, whereas Sofosbuvir inhibits the NS5B protein, which is also an essential protein in the replication of the hepatitis C virus.
  • Hepcinat Plus 60mg/400mg Tablet is a direct-acting antiviral medication that is used to increase the effectiveness in treating HCV.

Safety Advice

Alcohol
The interaction of alcohol with this tablet is still unknown. It is advisable not to consume alcohol while taking Hepcinat Plus 60mg/400mg Tablet. Consult your doctor for further information.
Pregnancy
Hepcinat Plus 60mg/400mg Tablet may be considered unsafe during pregnancy. Please consult your doctor in such a condition. According to some research data, taking Hepcinat Plus 60mg/400mg Tablet during pregnancy has shown harmful effects on the developing baby.
Breast Feeding
Hepcinat Plus 60mg/400mg Tablet is probably not safe if you're breastfeeding. Kindly consult your doctor before taking Hepcinat Plus 60mg/400mg Tablet while breastfeeding, as there are chances that it may pass to the developing baby through the breast milk of the mother.
Driving
It is advisable not to drive or operate heavy machinery after taking Hepcinat Plus 60mg/400mg Tablet, as you may feel dizzy.
Kidney
Share your medical history with your healthcare expert in case of kidney disease before taking Hepcinat Plus 60mg/400mg Tablet. Patients with renal impairment must be careful while taking Hepcinat Plus 60mg/400mg Tablet. They may require adjustment in the dose.
Liver
Inform your doctor before starting Hepcinat Plus 60mg/400mg Tablet if you have liver disease to avoid any serious side effects. Patients with hepatic impairment must be careful while taking Hepcinat Plus 60mg/400mg Tablet. They may require adjustment in the dose.

Missed Doses

  • If you miss a dose of Hepcinat Tablet, take it as soon as you remember.
  • If it’s nearly time for your next scheduled dose, skip the missed one and continue with your regular routine.
  • Do not take two tablets at once to make up for the missed dose.

FAQs

Hepcinat plus 60mg/400mg tablet is an antiviral medication, used along with other medications, in the treatment of chronic Hepatitis C Virus (HCV) infection in adults.

References

  • Butt Z, Shah SMA. (2024). Daclatasvir plus Sofosbuvir with or without ribavirin in patients with chronic Hepatitis C genotype 3a in the Pakistani population - A real-world experience. Pak J Med Sci. 35(2):409-413 - https://pmc.ncbi.nlm.nih.gov/articles/PMC6500802/
  • Kapoor R., Kohli A., Sidharthan S. (2024). All oral treatment for genotype 4 chronic hepatitis C infection with sofosbuvir and ledipasvir: interim results from the NIAID Synergy Trial. Hepatology. 4(60).
  • Mehta V, Mahajan R, Midha V, Narang V, Kaur K, Singh A, Malhotra A, Parvez A, Sood A. (2023). Impact of Direct Acting Antiviral Therapy for Treatment of Hepatitis C Genotypes 1, 3, and 4: A Real-Life Experience from India. J Clin Exp Hepatol. 8(1):7-14 - https://pubmed.ncbi.nlm.nih.gov/29743791/
  • Rockstroh JK, Ingiliz P, Petersen J, Peck-Radosavljevic M, Welzel TM, Van der Valk M, Zhao Y, Jimenez-Exposito MJ, Zeuzem S. (2024). Daclatasvir plus sofosbuvir, with or without ribavirin, in real-world patients with HIV-HCV coinfection and advanced liver disease. Antivir Ther. 22(3):225-236 - https://pubmed.ncbi.nlm.nih.gov/27845298/
  • Shiha G, Soliman R, ElBasiony M, Hassan AA, Mikhail NNH. (2023). Sofosbuvir plus Daclatasvir with or without ribavirin for treatment of chronic HCV genotype 4 patients: real-life experience. Hepatol Int. 12(4):339-347 - https://pubmed.ncbi.nlm.nih.gov/29663115/
  • Swallow E, Song J, Yuan Y, Kalsekar A, Kelley C, Peeples M, Mu F, Ackerman P, Signorovitch J. (2024). Daclatasvir and Sofosbuvir Versus Sofosbuvir and Ribavirin in Patients with Chronic Hepatitis C Coinfected with HIV: A Matching-adjusted Indirect Comparison. Clin Ther. 38(2):404-12.
  • Tmu N, Kumar A, Sharma P, Singla V, Bansal N, Arora A. (2024).Results of Sofosbuvir Plus Ribavirin in Patients With Hepatitis C-Related Decompensated Cirrhosis. J Clin Exp Hepatol. 9(1):4-12.

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