
Hepcinat Plus 60mg/400mg Tablet
Salt Composition: Sofosbuvir 400mg + Daclatasvir 60mg
Expiry Date: 01/2028
Inclusive of all taxes
28 tablet
About The Product
Hepatitis C
Hepcinat Plus 60mg/400mg Tablet is an antiviral medication that is used in combination with other medicines. It is used in the treatment of chronic hepatitis C virus (HCV) infection. It stops or prevents the growth of viruses in the body and helps remove the virus from the blood. Hepcinat Plus 60mg/400mg Tablet helps you to recover faster and controls the infection from spreading in your body.
This is a prescription-based medicine, which is to be taken only when prescribed by your doctor. Usually taken once daily with or without food, the course of treatment lasts 12 to 24 weeks depending on the patient’s condition. While effective, it can cause side effects such as tiredness, headache, nausea, vomiting, fever, cough, trouble sleeping, changes in liver function, or allergic reactions.
Uses
Treatment of Chronic hepatitis C virus (HCV) infection
Side Effects
The human body reacts differently to Hepcinat Plus 60mg/400mg Tablet. Response or undesired symptoms vary from individual to individual. Usually, they disappear with time as the body adjusts to the medicine; these side effects don't need special medical attention. Whereas if the symptoms don't disappear with time or you have severe side effects, then consult your doctor immediately.
Some of the side effects of Hepcinat Plus 60mg/400mg Tablet are mentioned below:
- Headache
- Fever
- Chills
- Nausea
- Insomnia (difficulty in sleeping)
- Diarrhea
- Fatigue
- Allergic Reactions (Skin rash, Itching, irritability, breathing difficulty)
- Slow heart rate
- Liver issues
Dosage and Administration
- Take the dose of Hepcinat Plus 60mg/400mg Tablet as per your healthcare provider’s prescription.
- Do not stop taking the medicine suddenly unless your doctor tells you to.
- This medicine is given under the strict supervision of a doctor. Do not self-administer.
- Hepcinat Plus 60mg/400mg Tablet can be taken without food or with food.
- You should not break, crush, or chew the medicine; it should be swallowed as a whole.
Mechanism of action
- Hepcinat Plus 60mg/400mg Tablet is made by combining two medicines that are Sofosbuvir and Daclatasvir.
- They both lower the viral load in the body and the viruses in the blood. Daclatasvir inhibits a protein called NS5A, which is an important protein required for the replication of the hepatitis C virus, whereas Sofosbuvir inhibits the NS5B protein, which is also an essential protein in the replication of the hepatitis C virus.
- Hepcinat Plus 60mg/400mg Tablet is a direct-acting antiviral medication that is used to increase the effectiveness in treating HCV.
Safety Advice
Missed Doses
- If you miss a dose of Hepcinat Tablet, take it as soon as you remember.
- If it’s nearly time for your next scheduled dose, skip the missed one and continue with your regular routine.
- Do not take two tablets at once to make up for the missed dose.
FAQs
Hepcinat plus 60mg/400mg tablet is an antiviral medication, used along with other medications, in the treatment of chronic Hepatitis C Virus (HCV) infection in adults.
References
- Butt Z, Shah SMA. (2024). Daclatasvir plus Sofosbuvir with or without ribavirin in patients with chronic Hepatitis C genotype 3a in the Pakistani population - A real-world experience. Pak J Med Sci. 35(2):409-413 - https://pmc.ncbi.nlm.nih.gov/articles/PMC6500802/
- Kapoor R., Kohli A., Sidharthan S. (2024). All oral treatment for genotype 4 chronic hepatitis C infection with sofosbuvir and ledipasvir: interim results from the NIAID Synergy Trial. Hepatology. 4(60).
- Mehta V, Mahajan R, Midha V, Narang V, Kaur K, Singh A, Malhotra A, Parvez A, Sood A. (2023). Impact of Direct Acting Antiviral Therapy for Treatment of Hepatitis C Genotypes 1, 3, and 4: A Real-Life Experience from India. J Clin Exp Hepatol. 8(1):7-14 - https://pubmed.ncbi.nlm.nih.gov/29743791/
- Rockstroh JK, Ingiliz P, Petersen J, Peck-Radosavljevic M, Welzel TM, Van der Valk M, Zhao Y, Jimenez-Exposito MJ, Zeuzem S. (2024). Daclatasvir plus sofosbuvir, with or without ribavirin, in real-world patients with HIV-HCV coinfection and advanced liver disease. Antivir Ther. 22(3):225-236 - https://pubmed.ncbi.nlm.nih.gov/27845298/
- Shiha G, Soliman R, ElBasiony M, Hassan AA, Mikhail NNH. (2023). Sofosbuvir plus Daclatasvir with or without ribavirin for treatment of chronic HCV genotype 4 patients: real-life experience. Hepatol Int. 12(4):339-347 - https://pubmed.ncbi.nlm.nih.gov/29663115/
- Swallow E, Song J, Yuan Y, Kalsekar A, Kelley C, Peeples M, Mu F, Ackerman P, Signorovitch J. (2024). Daclatasvir and Sofosbuvir Versus Sofosbuvir and Ribavirin in Patients with Chronic Hepatitis C Coinfected with HIV: A Matching-adjusted Indirect Comparison. Clin Ther. 38(2):404-12.
- Tmu N, Kumar A, Sharma P, Singla V, Bansal N, Arora A. (2024).Results of Sofosbuvir Plus Ribavirin in Patients With Hepatitis C-Related Decompensated Cirrhosis. J Clin Exp Hepatol. 9(1):4-12.
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