Brand name - Hepcinat
Generic name - Sofosbuvir
Manufacturer - Natco Pharma Ltd.
Salt composition - Sofosbuvir 400mg
Storage - Store at room temperature (10-30°C)
Dosage form - Oral (tablet)
Strength - 400mg
Packaging - Bottle of 28 tablets
Gender - Unisex
Prescription required - Yes
Indication - Used in the treatment of chronic Hepatitis C Virus (HCV) infection
Hepcinat (Sofosbuvir) 400mg tablet is an antiviral medication, used along with other medications, in the treatment of chronic Hepatitis C Virus (HCV) infection in adults. This medicine works to lower the growth and multiplication of virus in the body and helps to eliminate the virus from the body.
Sofosbuvir tends to inhibit the Hepatitis C NS5B protein. It shows a high barrier to the development of resistance. Sofosbuvir is a prodrug of the Protide type, wherein the active phosphorylated nucleotide is granted with cell permeability and oral bioavailability. By hydrolysis of the carboxylate ester by either of the enzymes cathepsin A or carboxylesterase 1, Sofosbuvir is activated in the liver to the triphosphate GS-461203, which is followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), with repeated phosphorylation. Dephosphorylation tends to create the inactive metabolite GS-331077. The half life of Sofosbuvir is 0.4 hours, and the half life of GS-331077 is 27 hours. Following a single 400 mg oral dose of Sofosbuvir, 80% is normally excreted in urine, 2.5% in expired air recovery and 14% in feces.
The active ingredient of Hepcinat tablet is Sofosbuvir 400mg.
Usage of medicine
Hepcinat 400mg tablet is used to treat chronic (long-lasting) Hepatitis C Virus (HCV) infection in adults.
Common side effects
Serious side effects
Take Hepcinat tablet exactly as your healthcare provider tells you. Do not alter the dose strength on your own. Do not crush, chew or break the tablet.
If you miss a dose, take it as soon as you remember. If it is already the time for your next scheduled dose, do not take the missed dose. Do not try to double the dose in order to catch up.
Seek immediate medical attention, in case of overdose.
Warning and precautions
Don't forget to tell your healthcare provider about the medicines you already take and your medical history.
In patients with kidney or/and liver disease, Hepcinat tablet should be administered cautiously.
Avoid alcohol consumption.
During pregnancy and breastfeeding, this medicine should be administered only if the healthcare provider prescribes.
Do not crush, chew or break the Hepcinat 400mg tablet.
Q1- What is Hepcinat?
A- Hepcinat (Sofosbuvir) 400mg tablet is an antiviral medication, used along with other medications, in the treatment of chronic Hepatitis C Virus (HCV) infection in adults.
Q2- How can I take Hepcinat (Sofosbuvir) tablet?
A- Take Hepcinat tablet exactly as your healthcare provider tells you. Do not alter the dose strength on your own. Do not crush, chew or break the tablet.
Q3- In what strength is it available?
A- Hepcinat tablet is available in the strength of 400mg.
Q4- What are the possible side effects of Hepcinat (Sofosbuvir) tablet?
A- Side effects of Hepcinat are fever, nausea, anemia, insomnia, chills, muscle pain, cramps, fainting and skin rash. If you experience these or any other side effect(s), make sure to consult your healthcare provider for the same.
Q5- What are self care tips?
A- Note all the changes you observe and contact your healthcare provider accordingly.
Q6- What should I avoid while consuming this medicine?
A- Avoid the consumption of fatty or sugary foods and alcohol.
Q7- Can I drive after taking Hepcinat tablet?
A- Do not drive or operate heavy machines if you feel unwell after taking this medicine.
Q8- Can I take this medicine during pregnancy?
A- Take Hepcinat tablet only if your healthcare provider prescribes it.
Q9- Can I take this medicine during breastfeeding?
A- Take this medicine only if your healthcare provider tells you.
Q10- Can I take this medicine in liver disease?
A- In patients with liver disease, Hepcinat tablet should be administered cautiously.
Q11- Can I take this medicine in kidney disease?
A- In patients with kidney disease, Hepcinat tablet should be administered cautiously.
Q12- Can I consume alcohol after taking Hepcinat tablet?
A- Avoid alcohol consumption.
Q13- Is Hepcinat (Sofosbuvir) tablet a habit forming medicine?
A- No, it is not a habit forming medicine.