Hepcinat 400mg Tablet

​Sofosbuvir tends to inhibit the Hepatitis C NS5B protein. It shows a high barrier to the development of resistance. Sofosbuvir is a prodrug of the Protide type, wherein the active phosphorylated nucleotide is granted with cell permeability and oral bioavailability. By hydrolysis of the carboxylate ester by either of the enzymes cathepsin A or carboxylesterase 1, Sofosbuvir is activated in the liver to the triphosphate GS-461203, which is followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), with repeated phosphorylation. Dephosphorylation tends to create the inactive metabolite GS-331077. The half-life of Sofosbuvir is 0.4 hours, and the half-life of GS-331077 is 27 hours. Following a single 400 mg oral dose of Sofosbuvir, 80% is normally excreted in urine, 2.5% in expired air recovery, and 14% in feces.​

Most side effects of Hepcinat 400mg tabletdo not require medical attention as they may disappear as your body adjusts to the medicine. In case these side effects become worse, consult your doctor immediately.

Headache 

Fever

Chills

Nausea

Insomnia (difficulty in sleeping)

Tiredness

Loss of appetite

Fatigue 

Anemia (low number of red blood cells)

Skin rash

Itching

Irritability

​Take the Hepcinat tablet exactly as your healthcare provider tells you. Do not alter the dose strength on your own. Do not crush, chew, or break the tablet.

Seek immediate medical attention, in case of overdose.​​

​If you miss a dose, take it as soon as you remember. If it is already time for your next scheduled dose, do not take the missed dose. Do not try to double the dose to catch up.​