
Jakavi 10mg Tablet
Salt Composition: Ruxolitinib
Expiry Date: 01/2028
Inclusive of all taxes
10 Tablet(s) In A Strip
About The Product
Chronic graft Versus host disease
Description
Jakavi 10mg tablet is an anti-cancer medication. It is prescription based medication used mainly for blood disorders like myelofibrosis and polycythemia vera.Its active ingredient is Ruxolitinib which belongs to the group of janus kinase inhibitors.
It works by inhibiting the JAK enzymes, which play a key role in abnormal cell signaling and inflammation. By blocking these enzymes.
Ruxolitinib helps reduced uncontrolled cell growth, inflammation and related symptoms in blood disorders. Doctor's prescription is required for the treatment to ensure safe and effective treatment.
Uses
- Treat blood disorders, including myelofibrosis and polycythemia vera
Side Effects
Every medication has several side effects that are harmful to the body if not treated early. If you experience any of the symptoms, visit the doctor immediately to avoid complications during the treatment. Common ones include:
- Low red and white blood cell counts
- Low platelet counts
- Dizziness, headache
- Bruising
- Diarrhea
- Infections, including viral infections
- Swelling in the face and body
- Fatigue or tiredness
- Severe infections like hepatitis B
- Anemia
- Bleeding
How To Use
- Jakavi 10mg tablet should be taken with or without food at the fixed time everyday as recommended by the healthcare professional.
- Do not crush, break, or chew the tablet just swallow it whole glass of water.
- The doctor will decide the correct dosage and duration based on the patient's height, weight and response to the treatment.
- Always take the tablet according to the healthcare professional.
How It Works
Jakavi 10mg tablet works by inhibiting the JAK1 and JAK2 enzyme, which are involved in signaling pathways that regulate blood cell production and immune activity. By blocking the enzymes it helps reduce abnormal cell growth, lower inflammation and shrink enlarged spleens.
Thereby improving disease related symptoms and overall quality of life in affected patients.
Safety Advice
FAQs
Jakavi 10mg tablet should be taken by the patient of blood disorder such as chronic idiopathic myelofibrosis and polycythemia
References
- Mascarenhas, J., & Hoffman, R. (2012). Ruxolitinib: the first FDA approved therapy for the treatment of myelofibrosis. Clinical cancer research, 18(11), 3008-3014. https://pubmed.ncbi.nlm.nih.gov/22474318/
- Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., ... & Kantarjian, H. M. (2012). A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. New England Journal of Medicine, 366(9), 799-807. https://pubmed.ncbi.nlm.nih.gov/22375971/
- Elli, E. M., Baratè, C., Mendicino, F., Palandri, F., & Palumbo, G. A. (2019). Mechanisms underlying the anti-inflammatory and immunosuppressive activity of ruxolitinib. Frontiers in oncology, 9, 1186.
- Vannucchi, A. M., Kiladjian, J. J., Griesshammer, M., Masszi, T., Durrant, S., Passamonti, F., ... & Verstovsek, S. (2015). Ruxolitinib versus standard therapy for the treatment of polycythemia vera. New England Journal of Medicine, 372(5), 426-435.
- Harrison, C., Kiladjian, J. J., Al-Ali, H. K., Gisslinger, H., Waltzman, R., Stalbovskaya, V., ... & Barosi, G. (2012). JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. New England Journal of Medicine, 366(9), 787-798
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