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novartis
21 Tablet
Ribociclib
Keep in cold place
Delivering To:
Overview
Kryxana 200mg Tablet is used in the treatment of metastatic (cancer that has spread to other parts of the body) breast cancer. It belongs to a group of cancer-fighting medications known as antineoplastics. This tablet works by blocking the action of the kinase protein, which is important for the growth and division of cells. Close monitoring of blood cell count is required during treatment with this medicine.
Breast Cancer
Metastatic Breast Cancer
Most side effects of Kryxana 200mg Tablet do not require medical attention as they may disappear as your body adjusts to the medicine. In case these side effects become worse, consult your doctor immediately.
Seizures
Vomiting
Diarrhea
Chest tightness
Stomach pain
Nausea
Unusual tiredness
Itching
Changed sense of taste
Trouble sleeping
Headache
Decreased white blood cell count
Back pain
Tingling of hands and feet
Take Kryxana 200mg Tablet as prescribed by your doctor. Do not stop or skip your regular dosing schedule. In case of an overdose of Kryxana Tablet, consult your doctor immediately for emergency medical treatment.
Ribociclib is an inhibitor of cyclin-dependent kinase (CDK) 4 and 6. These kinases are activated upon binding to D-cyclins and play a crucial role in signaling pathways that lead to cell cycle progression and cellular proliferation. After the oral administration, the effect of Kryxana 200mg Tablet can be observed in 2 to 4 hours. This slows the growth of cancer cells and eventually kills them.
Alcohol
unsafe
It is advisable not to consume alcohol while taking medicine.
Pregnancy
consult your doctor
Do not take Kryxana 200mg Tablet without consulting the doctor, in case of pregnancy.
Breast Feeding
consult your doctor
Without a doctor's consultation, do not take this medicine if you're breastfeeding.
Driving
danger
It is advisable not to drive or operate heavy machinery, you may feel dizzy as one of the side effects of the medicine.
Kidney
caution
Do not consume Kryxana 200mg Tablet without a doctor's consultation in case of kidney problems.
Liver
caution
Share your medical history with the doctor in case of liver disease before taking this medicine.
If you forget to take a dose of Kryxana Tablet, consult your doctor. Don’t double up the next dose to cope with the missed one unless your doctor recommends it.
It is an anti-cancer medication that is used in the treatment of breast cancer. This medicine helps to stop the growth of cancer cells.
Kryxana 200mg Tablet works by blocking the action of the kinase protein which is important for the growth and division of cells.
Some common side effects of Kryxana 200mg Tablet are allergic reactions, fast heartbeat, bleeding, seizures, diarrhea, back pain, and constipation.
Avoid the consumption of pomegranate and grapefruit during treatment with this medicine.
Kryxana 200mg Tablet may affect your vision and your ability to concentrate. It is advised not drive in such conditions.
Abdelmalak, M., Singh, R., Anwer, M., et al. (2022). The renaissance of CDK inhibitors in breast cancer therapy: An update on clinical trials and therapy resistance. Cancers, 14(21), 5388.
Dajsakdipon, T., Susiriwatananont, T., Wongkraisri, C., Ithimakin, S., Parinyanitikul, N., Supavavej, A., & TSCO Breast Oncology Group. (2024). Comparative effectiveness analysis of survival with first-line palbociclib or ribociclib plus aromatase inhibitor in HR+/HER2− advanced breast cancer: Preliminary real‑world data from Thailand. BMC Cancer, 24(1), 1018.
Hortobagyi, G. N., Stemmer, S. M., Burris, H. A., Yap, Y. S., Sonke, G. S., Paluch-Shimon, S., … Goetz, M. P. (2022). Overall survival with ribociclib plus letrozole in advanced breast cancer. New England Journal of Medicine, 386(18), 942–950.
Ji, Y., Yartsev, V., Quinlan, M., Serra, P., Wang, Y., Chakraborty, A., & Miller, M. (2023). Justifying ribociclib dose in patients with advanced breast cancer with renal impairment based on PK, safety, and efficacy data: An innovative approach integrating data from a dedicated renal impairment study and oncology clinical trials. Clinical Pharmacokinetics, 62(3), 493–504.
Xu, J., Wang, R., & Shen, K. (2025). A post-marketing disproportionality analysis of the safety of ribociclib based on the FDA Adverse Event Reporting System. Therapeutic Advances in Drug Safety, 16, 20420986251324633.
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