Marketed By
Arechar HealthCare
Pack of
30 Tablet
Salt Composition
Pazopanib
Storage
Keep in cold place
₹2350₹10311.56
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1

Paznib 400mg Tablet
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Overview
Paznib 400mg Tablet is an anticancer medicine that belongs to the group of medicines known as protein kinase inhibitors. It is prescribed in the treatment of renal cell carcinoma (kidney cancer) and advanced soft tissue sarcoma. The active ingredient of this anticancer medicine is Pazopanib. It is an antineoplastic drug, which means it stops cancer cells from spreading to other organs of the body.
Indication
Kidney Cancer
Side Effects
Like most anticancer drugs, Paznib 400mg Tablet may cause some adverse effects on the body during the treatment. These can vary from mild to severe depending on the dose and the patient’s health condition.
Common side effects include:
Hypertension
Color change of hair and skin
High glucose levels
Difficulty in breathing
Decrease in weight and appetite
Diarrhea
Nausea and vomiting
Muscle and joint pain
Headache
Tiredness
Some serious side effects:
Frequent Infections
Bleeding from the anus and mouth
Hypothyroidism
Heart problems
Interstitial lung disease
Inform your doctor immediately if you experience any persistent or unusual side effects.
How To Use
The dosage and treatment duration with Paznib 400mg Tablet is determined by the doctor as per the stage & type of cancer and the overall patient's health condition. It should be taken orally with water and should not be chewed, crushed, or broken. This capsule should be taken at least two hours after a meal or one hour before a meal at the fix time every day to get effective results. Don't miss a dose or overdose on the medicine.
How It Works
Paznib 400mg Tablet is an anticancer medicine that belongs to the class of protein kinase inhibitors. This medicine works by binding and blocking the activity of the enzyme receptors (tyrosine kinase) that are responsible for the multiplication of the cancerous cells in the body. Paznib Tablet also stops the growth of new blood vessels within the tumor. It effectively slows down the progress.
Safety Advice

Alcohol
consult your doctor
Avoid the consumption of alcohol while taking Paznib 400mg Tablet, as alcohol can reduce the effectiveness of the medicine and worsen the symptoms

Pregnancy
consult your doctor
Do not take Paznib 400mg Tablet without consulting the doctor in case of pregnancy, as it is an unsafe medicine during this period.

Breast Feeding
consult your doctor
Paznib 400mg Tablet is unsafe to use during breastfeeding as it may cause toxicity to the baby.

Driving
unsafe
Paznib 400mg Tablet may cause side effects such as dizziness or lack of concentration, which could affect your ability to drive. So it's better to avoid driving or operating heavy machinery.

Kidney
safe if prescribed
Paznib 400mg Tablet is safe for use in kidney disease if prescribed by the doctor. No dosage adjustment is necessary for this Tablet.

Liver
safe if prescribed
Consumption of Paznib 400mg Tablet should be avoided without informing the doctor if you have any liver-related issues.
Missed Doses
It is advised not to miss any scheduled dosage of Paznib 400mg Tablet. In case you miss a dose, consult your doctor immediately.
Don't overdose to compensate for the missed one. Contact your doctor or any healthcare provider and seek medical attention immediately in such cases.
Quick Tips
It is advised not to drink grapefruit juice during the treatment with Paznib 400mg Tablet, as there is the possibility that it may increase the severity of the side effects of the medicine.
Always use effective contraception when any of the partners are undergoing treatment with Paznib 400mg Tablet or at least 2 weeks after the last dose of the medicine to prevent pregnancy.
FAQs
In case you forgot to take a dose of Paznib Tablet, consult your doctor immediately. It is advised not to overdose for a missed dose of medicine.
Yes, there is a possibility of liver toxicity in a condition where the patient is taking Paznib 400mg tablet for a longer period. It may also lead to liver failure in severe conditions. Inform your healthcare expert if you have any kind of history of liver disorders before starting treatment with this medicine.
Change of hair color is a common side effect observed after some time of taking Paznib 400mg tablet. This change gradually develops after a few months of therapy.
There will be a reduction of red blood cells after taking the Paznib 400mg tablet. These RBCs help to transport oxygen throughout the body. When the count of these red blood cells becomes low, it results in a health condition known as anemia. It results in feeling tired most of the time and difficulty breathing. Inform your doctor if you experience any of these symptoms.
Paznib 400mg tablet is used to treat specific types of cancer, mainly kidney and soft tissue sarcoma. It works by decreasing the blood supply to the tumor, resulting in the death of cancer cells.
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Reference
1. Bukowski, R. M., Yasothan, U., & Kirkpatrick, P. (2010). Pazopanib. Nature reviews Drug discovery, 9(1), 17-18.
2. Miyamoto, S., Kakutani, S., Sato, Y., Hanashi, A., Kinoshita, Y., & Ishikawa, A. (2018). Drug review: pazopanib. Japanese Journal of Clinical Oncology, 48(6), 503-513.
3. Sonpavde, G., & Hutson, T. E. (2007). Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Current oncology reports, 9(2), 115-119.
4. Schutz, F. A., Choueiri, T. K., & Sternberg, C. N. (2011). Pazopanib: Clinical development of a potent anti-angiogenic drug. Critical reviews in oncology/hematology, 77(3), 163-171.
5. Hutson, T. E., Davis, I. D., Machiels, J. P. H., De Souza, P. L., Rottey, S., Hong, B. F., ... & Figlin, R. A. (2010). Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology, 28(3), 475-480.
6. Motzer, R. J., Hutson, T. E., Cella, D., Reeves, J., Hawkins, R., Guo, J., ... & Choueiri, T. K. (2013). Pazopanib versus sunitinib in metastatic renal-cell carcinoma. New England Journal of Medicine, 369(8), 722-731.
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