Rebopag 50mg Tablet

Rebopag 50mg Tablet

Salt Composition: Eltrombopag Olamine

Expiry Date: 01/2028

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7 Tablets in Strip

About The Product

Low Blood Platelet Count

Description

Rebopag 50mg tablet is a Thrombopoietin (TPO) receptor agonists (TPO-RAs). It stimulates the bone marrow to produce more platelets by activating TPO receptors on stem cells and megakaryocytes.

The medication is used to treat low platelets counts thrombocytopenia from conditions like chronic immune (idiopathic) and chronic hepatitis C virus. It is also used to treat severe aplastic anemia. Its active salt composition is Eltrombopag Olamine which belongs to the class of hematopoetic growth factor agents that help increase platelet production.

Uses

  • Treats patients with low platelet count

Side Effects

  • Rebopag 50mg tablet ca cause various side effects, mostly depend on the patient response to the treatment.
  • Common symptoms include: • Cough • Respiratory tract infection • Back pain • High temperature, cough • Loss of appetite • Hair loss • Swelling in feet or hands • Headache, dizziness • Mouth and throat pain • Joint pain • Nausea • Diarrhea, abdominal pain • Common cold

How To Use

  • Rebopag 50mg tablet should be taken orally, do not crush, chew or break the tablet just swallow it whole with a glass of water. Doctor will decide the correct dosage and duration of the medication, based on the disease condition and other factors.
  • Follow the recommended dosage as advised by the healthcare professional to ensure safe and effective treatment.​

How It Works

  • Rebopag tablet acts like thrombopoietin (a natural hormone). It binds to receptors on bone marrow cells and stimulates the production of megakaryocytes, the cells that make platelets.
  • In this way, it increases platelet count in the blood. This helps reduce the risk of bleeding in patients with low platelet levels.​​

Safety Advice

Alcohol
Taking Rebopag 50mg tablet with alcohol may be dangerous to the patient's health but consult the doctor before taking the medication.
Pregnancy
Rebopag 50mg tablet is not recommended to pregnant and breastfeeding women as it may affect the fetus or newborn. Take guidance from a healthcare expert to ensure safety and precautions.
Breast Feeding
Breastfeeding women should not be advisable for taking Rebopag 50mg tablet as the medicine is passed through breast that somehow affect breast milk. Discuss with the doctor for more query.
Driving
Rebopag 50mg tablet may not cause dizziness or sleepiness but patient may still experience some side effects. It is important to monitor the response of medication and report any unusual symptoms to the doctor.
Kidney
Kidney patients should take precautions while using Rebopag 50mg tablet as dose adjustment and doctor's prescription is much needed.
Liver
Rebopag 50mg tablet may interrupt with liver function. Patients with liver disease should consult the doctor before using it.

FAQs

• Follow the prescription as recommended by the healthcare professional • Monitor the side effects to ensure safety and effectiveness. • Swallow the whole tablet without chewing or crushing it.

• Avoid driving or dizziness while taking the medication

References

  • Dandabattina, R., Subramanian, V. B., Merugu, K. S., SharathBabu, H., Katari, N. K., & Kowtharapu, L. P. (2023). Stability-indicating RP-HPLC method development and validation for eltrombopag olamine in the presence of impurities and degradation products. Robustness by design of expert software. Journal of AOAC International, 106(2), 267-275. https://pubmed.ncbi.nlm.nih.gov/36416121/
  • Ganorkar, S. B., Bobade, P. S., Prabhu, R. C., Lokwani, D. K., Shinde, R. N., Telange, D. R., ... & Vander Heyden, Y. (2024). Extension of impurity profiling on eltrombopag olamine to in-silico predictions: An effort to exploit correlated forced degradation products and known drug-related substances in drug discovery. Journal of Chromatography B, 1248, 124367. https://pubmed.ncbi.nlm.nih.gov/39547062/
  • Jayagopal, B., & Murugesh, S. (2021). QBD-driven HPLC method of eltrombopag olamine: Degradation pathway proposal, structure elucidation, and in silico toxicity prediction. Journal of Pharmaceutical and Biomedical Analysis, 203, 114231. https://pubmed.ncbi.nlm.nih.gov/34225039/
  • Kaduk, J. A., Gindhart, A. M., & Blanton, T. N. (2021). Crystal structure of eltrombopag olamine form I,(C2H8NO) 2 (C25H20N4O4). Powder Diffraction, 36(2), 100-106.
  • Wang, J., Zhao, Z., Tao, Y., & Lan, Y. (2024). Bioequivalence and Food Effect Assessment of Eltrombopag Olamine Tablets in Healthy Chinese Subjects: An Open, Randomized, Single‐Dose, and Two‐Period Crossover Study. Clinical Pharmacology in Drug Development, 13(11), 1260-1266.

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