What is the right way of taking the Regonat 40mg Tablet?

Regonat Tablet is taken orally with or without food as per the doctor's advice. It is consumed at the same time each day for better results. It is recommended not to crush, chew, or split the capsules; take them as a whole.

What are the commonly observed side effects of Regonat 40mg Tablet?

Renogat 40 mg side effects include allergic reactions, liver problems, bleeding, gastrointestinal perforation, infections, heart attack, high blood pressure, pancreatitis, skin reactions, neurological issues, blood vessel complications, low white blood cells, hypothyroidism, electrolyte imbalances, dehydration, headaches, tremors, neuropathy, taste changes, digestive issues, hair loss, rashes, muscle spasms, protein in urine, pain, fever, nausea, diarrhea, decreased appetite, weight loss, mucosal inflammation, and bilirubin in urine.

Who should avoid taking Regonat 40mg Tablet?

People diagnosed with severe liver and kidney disorders and pregnant and breastfeeding women are advised to consult their healthcare professionals before taking this medicine.

Can the Regonat 40mg Tablet be given in combination therapy with other medications?

Yes, regonat is given alone or in combination with other medicines to treat other cancer or to increase treatment effectiveness.

Are 40 mg tablets of Regonat considered chemotherapy?

When other drugs and therapies fail to treat stomach, colon, or rectal cancer, Regonat 40 mg tablets are used as chemotherapy.

Is taking a 40 mg tablet of Regonat when pregnant safe?

Due to its adverse impacts on the developing baby, this medicine should not be used by anybody who is planning to become pregnant or who is already pregnant. Consult your doctor for any query or confusion.

Are the medicines genuine?

Absolutely, we ensure that the medicines we sell are procured from reliable sources and hence are always genuine.

Is there any need for a prescription?

Medicines which require a prescription are delivered only upon receipt of a prescription.

Do you deliver across all parts of India?

Magicine Pharma provides medicines and other healthcare products delivery services across all parts of India as well as several other countries with efficient and reliable delivery.

Can hospitals and clinics order in bulk?

Yes. We cater to hospitals, clinics, pharmacies, and all such healthcare institutions by delivering our bulk medicines to them.

How can I get in touch with Magicine Pharma?

Magicine Pharma will help you out in case of any question related to the availability of medicines and ordering.

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Regonat 40mg Tablet

Name: Regonat 40mg Tablet
Brand: regonat
Price: 7000 INR
Availability: InStock
Author: Venika Choudhary

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Salt Composition: Regorafenib

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28 Tablet

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Regonat 40mg Tablet

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The price displayed is the MRP (inclusive of applicable taxes). Any additional fee (such as shipping fee, handling and/or platform fee etc.) will be clearly disclosed before you complete your purchase.

About The Product

Colorectal Cancer
Gastrointestinal Stromal Tumors (GIST)
Liver Cancer (Hepatocellular Carcinoma)

Regonat 40 mg Tablet is a prescription anti-cancer medicine containing Regorafenib, mainly used for advanced colorectal cancer, gastrointestinal stromal tumors (GIST), and liver cancer when other treatments are no longer effective.

Regorafenib 40mg is a kinase inhibitor that stops the functioning of certain enzymes to inhibit cancer cells' proliferation and prevent their nutrition through blood vessels. The tablet should be taken with a low-fat meal at the same time each day, swallowed whole without crushing or chewing.

Because it is a potent medicine, treatment must be supervised by an oncologist, with regular blood tests to monitor liver function and blood cells. Common side effects include diarrhea, infection, high blood pressure, hand-foot syndrome, fatigue, rash, and digestive issues, and it is not recommended during pregnancy or breastfeeding.

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Side Effects

The human body shows undesired symptoms after taking Regonat 40mg Tablet. It is advised to consult your doctor if these symptoms become unmanageable. Some of the side effects of Regonat Tablet are mentioned below:

Allergic reactions
Severe liver problems
Bleeding or abnormal clotting
Gastrointestinal perforation
Infections
Severe chest pain & Heart attack
Severely high blood pressure
Pancreatitis
Skin cancers, severe skin eruptions, rashes, detachment (including Stevens-Johnson syndrome)
Confusion, seizures, headaches, vision loss (with or without high blood pressure)
Enlargement or tear of a blood vessel
Reduced white blood cells
Hypothyroidism
Electrolyte imbalances (low phosphate, potassium, calcium, sodium, magnesium)
Elevated uric acid
Dehydration
Headache, tremors
Peripheral neuropathy (numbness, tingling, weakness, pain)
Changes in taste, dry mouth
Heartburn, nausea, diarrhea
Gastroenteritis (stomach inflammation/infection)
Hair loss (alopecia), dry skin, mild rashes
Muscle spasms
Protein in urine
Pain, fever
High blood pressure
Decreased appetite, weight loss
Mucosal inflammation
Bilirubin in urine

Safety Advice

Alcohol

The interaction of alcohol with this drug is still unknown. It is advisable not to consume alcohol while taking Regonat 40mg Tablet. It is advised to consult your doctor for further information.

Pregnancy

Regonat Tablet is not advised during pregnancy due to proven fetal risks, though doctors may prescribe it in certain cases where the potential benefits outweigh the possible dangers.

Breast Feeding

Regonat Tablet may not be safe during breastfeeding, as it can pass into breast milk and potentially harm the newborn baby; it should only be used if the benefits clearly outweigh the risks, so always consult your doctor before use.

Driving

It is advisable not to drive or operate heavy machinery as you may feel dizzy after taking Regonat 40mg Tablet.

Kidney

Share your medical history with your healthcare expert in case of kidney disease before taking Regonat 40mg Tablet.

Liver

Inform your doctor before starting Regonat 40mg Tablet if you have liver disease to avoid any serious side effects.

Quick Tips

Hepatotoxicity can be reported, so liver function tests should be monitored regularly.
Hemorrhagic events may occur; therefore, patients should be closely monitored for any signs of bleeding. Inform your doctor in such cases.
Hand-Foot Skin Reaction (HFSR) is a common side effect of this tablet.
Blood pressure should be checked regularly.
The medicine impairs wound healing; it should be discontinued before any planned surgery. Therefore, inform your doctor accordingly.
It is advised to use effective birth control ways and avoid pregnancy during the treatment with Regonat 40mg Tablet.
A person should avoid smoking while undergoing treatment with Regonat 40mg Tablet. Smoking may reduce the effectiveness of medicine.
Monitor your blood sugar & pressure, kidney & liver function (KFT & LFT), and heart function at proper intervals after taking Regonat 40mg Tablet.
Skin becomes extremely sensitive after taking Regonat 40mg Tablet. It is advised to cover your skin exposed to direct sun rays and use high SPF sunscreen before going out.
It is advised to avoid taking analgesics/antacids (medicines used to neutralize the stomach acid) while taking Regonat 40mg Tablet, as it may reduce the effectiveness of the medicine.
Keep your body hydrated, as diarrhea is one of the common side effects experienced after taking Regonat 40mg Tablet. Consult your doctor if it doesn't stop or if blood appears in your stools.
If you experience any kind of symptoms after taking Regonat 40mg Tablet like unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever), or other signs of infection, it is important to inform your doctor as soon as possible.

FAQs

This medicine is given to adults diagnosed with Colorectal cancer, Gastrointestinal stromal tumors, and Liver cancer.

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At our pharmacy, your health is our top priority. All of our medicines are safe, effective, and approved by leading health authorities.

We partner exclusively with reliable and reputable manufacturers, ensuring the highest quality standards in every product we deliver. Enjoy the convenience of fast home delivery, secure packaging, and affordable prices—plus special discounts on bulk orders.

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References

Kato, T., Kudo, T., Kagawa, Y., Murata, K., Ota, H., Noura, S. & Eguchi, H. (2023). Phase II dose titration study of regorafenib in progressive unresectable metastatic colorectal cancer. Scientific Reports, 13(1), 2331 - https://pubmed.ncbi.nlm.nih.gov/36759648/
Ma, W., Li, Y., Lu, Y., Liang, Z., Yu, H., Han, J. & Cheng, J. (2025). A Multicenter Retrospective Study: Impact of First-Line Treatment Strategies on Second-Line Efficacy and Safety of Regorafenib with or Without PD-1 Inhibitors in Unresectable Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma, 2123-2137 - https://pubmed.ncbi.nlm.nih.gov/40980778/
Skårderud, M. R., Polk, A., Vistisen, K. K., Larsen, F. O., & Nielsen, D. L. (2022). Efficacy and safety of regorafenib in the treatment of metastatic colorectal cancer: a systematic review. Cancer treatment reviews, 62, 61-73 - https://pubmed.ncbi.nlm.nih.gov/29175677/
Yan, T., Huang, C., Peng, C., Duan, X., Ji, D., Duan, Y.& Lu, Y. (2023). A multi-center retrospective study on the efficacy and safety of regorafenib vs. regorafenib combined with PD-1 inhibitors as a second-line therapy in patients with advanced hepatocellular carcinoma. Annals of Translational Medicine, 11(2), 109 - https://pubmed.ncbi.nlm.nih.gov/36819518/
Zhang, W., Zhao, Y., Ma, G., Zhang, Y., Guo, Y., & Chen, Z. (2023). Efficacy and safety of regorafenib alone or in combinations in the second-line setting for advanced hepatocellular carcinoma: A multicenter real-world study. Journal of Gastrointestinal Oncology, 12(4), 1549 - https://pubmed.ncbi.nlm.nih.gov/38989425/
Zhao, J., Guo, Y., Feng, T., Rong, D., Kong, X., Huang, T. & Xia, Y. (2023). Efficacy and safety of regorafenib in combination with immune checkpoint inhibitor therapy as second-line and third-line regimen for patients with advanced hepatocellular carcinoma: A retrospective study. Journal of Gastrointestinal Oncology, 14(6), 2549 - https://pubmed.ncbi.nlm.nih.gov/38196523/

Certified Content

Written By

Venika Choudhary

Medical Content Writer @ Magicine Pharma

Reviewed By

Dr. Aditya Sarin - Consultant Medical Oncology

MBBS, MD - General Medicine, DNB - Medical Oncology Medical Oncologist 11 Years Experience

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Customer feedback

Ratings & reviews

Real purchase experiences from verified buyers — swipe cards sideways to read more.Real purchase experiences from verified buyers — scroll the grid below.

Overall

4.57

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Tanvi Agarwal

2025-09-11T06:02:52.521Z

Verified purchase

Good value for money

Good quality product. Regonat 40mg Tablet has been working well for me. The delivery was on time and packaging was good. It's a reliable product and I'm happy with my purchase.

Evelyn W.

2025-07-22T13:15:37.263Z

Verified purchase

Great product for daily use

Ordered this last month and it's been great. Very happy with Regonat 40mg Tablet! The quality is top-notch and it's been serving me well. The delivery was quick and packaging was intact. Overall, a great experience and I would definitely order again.

Yash Malhotra

2025-07-12T14:13:55.959Z

Verified purchase

Exceeded my expectations

Perfect product! Regonat 40mg Tablet meets all my expectations. The quality is outstanding and delivery was prompt. Very happy with the purchase and would recommend to others.

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Regonat 40mg Tablet

Regonat 40mg Tablet

About The Product

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Venika Choudhary

Dr. Aditya Sarin - Consultant Medical Oncology

Tanvi Agarwal

Evelyn W.

Yash Malhotra