Mfd. by :- Cipla Ltd (Fulfilled By : Magicine Pharma)
Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.
Brand name- Rolimus
Generics- Everolimus
Manufacturer- Cipla Ltd.
Dosage form- Tablet
Route of Administration- oral
Strength- 5, 10mg
Composition- Everolimus
Packaging- Strip (30 Tablets)
Indication- Immunosuppressant and for breast cancer, pancreatic cancer, lung cancer and kidney cancer.
Storage- Store at room temperature (10-30°C)
Class of drug- Anti-neoplastic (Macrolide Lactams)
It belongs to a class of medications called kinase inhibitors.Rolimus treats cancer by inhibiting cancer cells from growing further and by decreasing blood supply to the cancer cells.Rolimus prevents transplant rejection by decreasing the activity of the immune system.
Weakness, Sinus inflammation, Infection, Fever, Cough, Fatigue, Stomatitis (Inflammation of the mouth), Otitis media (infection of ear), Diarrhea, Upper respiratory tract infection (UTI).
It is study of drug effects and what the medicine does to the body.
Rolimus binds with high affinity to the FK506 binding protein-12 (FKBP-12), thereby forming a drug complex that stop the activation of mTOR. This inhibition reduces the activity of growth stages in cancer cells, and subsequently inducing cell growth arrest and apoptosis.
Study of what the body does to the medicine. Rolimus is absorbed rapidly and reaches peak concentration after 1.3-1.8 hours. Steady-state is reached within 7 days.
Minimum effect concentration (MEC)
Minimum concentration of medicine in the blood required for producing the therapeutic effects. Its predefined therapeutic MEC is ( 3 ng/mL)
Minimum toxic concentration (MTC)
Minimum concentration of medicine in blood above which toxic or adverse effects are precipitated. Its MTC is 8ng/mL
After oral administration, the medicine archived approximately 20% bioavailability.
Shelf life is the time period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at the time of manufacture.
Its shelf life is 2years
Which disease area
Breast cancer, pancreatic cancer, lung cancer and kidney cancer.
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Do not use the medicine if you are allergic to it.
. Using this medicine can increase the risk of serious infections or getting certain cancers, such as lymphoma or skin cancer.
Tell your doctor if you have ever had:
- problems digesting lactose or galactose (sugar)
- high cholesterol or triglycerides
- a heart transplant
- skin cancer in you or a family member
diarrhea
constipation
change the inability to taste food
weight loss
dry mouth
weakness
headache
difficulty falling asleep or staying asleep
nosebleed
dry skin
acne
problems with nails
hair loss
pain in the arms, legs, back or joints
muscle cramps
missed or irregular menstrual periods
heavy menstrual bleeding
difficulty getting or keeping an erection
anxiety
aggression or other changes in behavior
hives
itching
swelling of the hands, feet, arms, legs, eyes, face, mouth, lips, tongue, or throat
hoarseness
difficulty breathing or swallowing
wheezing
flushing
chest pain
extreme thirst or hunger
unusual bleeding or bruising
pale skin
fast or irregular heartbeat
dizziness
seizures
If the patient misses a dose of medicine, skip it and continue with the normal schedule. No need to double the dose
Get the emergency medical treatment and contact your physician
General warning and precautions
Consult your doctor in case if you experience increased thirst or increased frequency of urination, if you get any infection, suffer from shortness of breath, cough or fever, you need to receive any vaccination after taking Rolimus..
Do not chew, crush or break it but swallow the medicine. Rolimus 10mg Tablet may be taken with or without food, but it is better to take it at a fixed time..
Rolimus is an immunosuppressant medicine to be used along with other medicines to prevent the body from rejecting a kidney or a liver organ transplant. It is also used to treat certain types of cancers of the breasts, kidneys, pancreas, intestines, lungs, brain, etc.
Rolimus treats cancer by inhibiting cancer cells from growing further and by decreasing blood supply to the cancer cells.Rolimus prevents transplant rejection by decreasing the activity of the immune system.
Side Effects of Rolimus are Weakness, Sinus inflammation, Infection, Fever, Cough, Fatigue, Stomatitis (Inflammation of the mouth), Otitis media (infection of ear), Diarrhea, Upper respiratory tract infection (UTI).
It is available in 5 and 10mg
Avoid grape juice and smoking while taking the medication
Rolimus 10mg Tablet may be taken with or without food by swallowing, but it is better to take it at a fixed time.
If you miss a dose of medicine, skip it and continue with the normal schedule. No need to double the dose
Use of Rolimus is not recommended if you have some serious liver-related disorders.
Do not drive if you have any symptoms that affect your ability to concentrate and react.
Rolimus is not safe to use during pregnancy as there is proven evidence of risk to the developing baby.
Rolimus is probably not safe to use during breastfeeding.
It is not known, consult your doctor
There is no affect on the kidney functions
Store the medicine at room temperature (10-30°C)
Clarithromycin
Ritonavir
Rifampicin
Phenytoin
Carbamazepin
Amlodipine
Danazol
If the patient is suffering from any of the following diseases, you should not take Rolimus -
Liver Disease
Kidney Disease
Infections
Pneumonitis
Lymphoma
Diabetes Type 2
Diabetes
Alcohol interaction is unknown, consult your doctor
The patient should also avoid grapefruit and grapefruit juice while taking the medicine.
It includes Hypersensitivity
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