How should I take a Sofovir Tablet?

Do not crush, chew, or break the tablet. Take it exactly as your healthcare provider tells you.

What are the storage conditions for Sofovir 400mg?

Store at room temperature (10-30°C). Keep it covered, and away from children, direct light, heat, and moisture.

What are the possible side effects of Sofovir 400mg Tablet?

There can be some side effects of Sofovir such as fever, headache, irritability, anemia, fatigue, and diarrhea. Nausea and skin rash. Kindly consult your healthcare provider if you experience these or any other side effects.

Can I drive after taking this medicine?

Do not drive or operate heavy machines in case you feel unwell after taking Sofovir 400mg.

Can elderly persons take 400 mg tablets of sofovir?

Yes, senior patients can utilize 400 mg tablets of sofovir. Its usage is not prohibited by age alone. However, older patients may be more likely to have illnesses and to be taking more than one medicine, which can raise the possibility of drug interactions.

Can the 400 mg Sofovir tablet stop the spread of hepatitis C?

The main treatment for Sofovir 400mg Tablet is for people who already have hepatitis C. It can treat the infection and lower the viral load, but it doesn't directly prevent against developing hepatitis C or stopping its spread to other people. Using barrier techniques during intercourse, avoiding sharing needles or other drug paraphernalia, and taking steps to avoid blood-to-blood contact are all examples of safe behaviors that can prevent the spread of hepatitis C.

Can people with liver cirrhosis utilize 400 mg tablets of sofovir?

Yes, people with liver cirrhosis can take 400 mg tablets of sofovir. Patients with liver cirrhosis have proven its effectiveness and safety. Patients with severe liver disease, however, could need specialized treatment programs and close monitoring.

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Sofovir 400mg Tablet

Name: Sofovir 400mg Tablet
Brand: sofovir
Price: 7089.48 INR
Availability: InStock
Rating: 4.57 (7 reviews)

Rx Required

Salt Composition: Sofosbuvir 400mg

Expiry Date: 01/2028

Price on Request

Inclusive of all taxes

▼

28 tablet

About The Product

Hepatitis C

Sofosbuvir is the active ingredient of Sofovir 400mg Tablets. Hepatitis C virus (HCV) infection is treated with this direct-acting antiviral drug. In order to create a regimen that will successfully remove HCV from the body, this medication is frequently taken in combination with other antiviral medications.

When compared to earlier treatments, the Sofovir 400mg Tablet has considerably reduced the length of time needed to treat HCV. It works well against a variety of hepatitis C virus genotypes. A wide variety of patients with varying HCV genotypes can benefit from this type of therapy due to its broad-spectrum action.

Side Effects

Sofovir 400mg Tablet may cause some serious and unwanted side effects that require immediate medical attention; otherwise, it can also lead to a higher risk. Do not forget to discuss the risks and benefits of this medication with your doctor.

Insomnia
Nausea
Fainting
Neutropenia (low white blood cell count)
Chills and fever
Fatigue
Headache
Loss of appetite
Itching Joint pain

How It Works

Sofosbuvir tends to inhibit the Hepatitis C NS5B protein. It shows a high barrier to the development of resistance. Sofosbuvir is a prodrug of the Protide type, wherein the active phosphorylated nucleotide is granted with cell permeability and oral bioavailability.

By hydrolysis of the carboxylate ester by either of the enzymes cathepsin A or carboxylesterase 1, Sofosbuvir is activated in the liver to the triphosphate GS-461203, which is followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), with repeated phosphorylation.

Dephosphorylation tends to create the inactive metabolite GS-331077. The half-life of Sofosbuvir is 0.4 hours, and the half-life of GS-331077 is 27 hours. Following a single 400 mg oral dose of Sofovir Tablet, 80% is normally excreted in the urine, 2.5% in expired air recovery, and 14% in feces.

Safety Advice

Alcohol

It is advisable not to consume alcohol while taking this medicine.

Pregnancy

Do not take Sofovir 400mg Tablet without consulting the doctor, in case of pregnancy.

Breast Feeding

Without a doctor's consultation, do not take this medicine if you're breastfeeding.

Driving

It is advisable not to drive or operate heavy machinery, you may feel dizzy as one of the side effects of the medicine.

Kidney

Do not take Sofovir 400mg Tablet without a doctor's consultation in case of kidney problems.

Liver

Share your medical history with the doctor in case of liver disease before taking this medicine.

FAQs

Sofovir 400mg Tablet is an antiviral medicine.

It is used with other medicines to treat chronic (long-lasting) hepatitis C virus (HCV) infection in adults.

Reference

AbdelMagid, A.M. et al. (2024). Population pharmacokinetics of ledipasvir/sofosbuvir in pediatric patients with acute lymphoblastic leukemia: A modeling study. Clinical Therapeutics - https://pubmed.ncbi.nlm.nih.gov/39706761/

Mizokami,M., Liu, L.J., Fujiama, N., Littman, M., Yuan, J., Sekiya, T., Hedskog, C., Ng, L. J. (2024). Real‑world safety and effectiveness of ledipasvir/sofosbuvir for treating chronic HCV genotype 1 in a Japanese cohort. Journal Name. Retrieved from PubMed - https://pubmed.ncbi.nlm.nih.gov/32869924/

Treatment options to support the elimination of hepatitis C: an open‑label, factorial, randomised controlled non‑inferiority trial. (2025). The Lancet Gastroenterology & Hepatology.

Viral Hepatitis Study Group of the Turkish Society of Clinical Microbiology and Infectious Diseases. (2025). Evaluation of treatment response in chronic hepatitis C patients receiving sofosbuvir/velpatasvir/voxilaprevir: A multicenter real‑world experience from Türkiye. Viruses, 17(7), 931 - https://pubmed.ncbi.nlm.nih.gov/40733548/

Zhuang, L., Li, J., Zhang, Y., Ji, S., & Xing, H. (2025). Real‑world effectiveness of sofosbuvir/velpatasvir, glecaprevir/pibrentasvir, and sofosbuvir/velpatasvir/voxilaprevir against genotype 3 hepatitis C virus infection: A systematic review and meta‑analysis. Frontiers in Gastroenterology, 4, 1511150 - https://www.frontiersin.org/journals/gastroenterology/articles/10.3389/fgstr.2025.1511150/full

Last updated: 4 Aug 2026 | 07:05 PM (IST)

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