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Sorafenat 200mg Tablet

Sorafenat 200mg Tablet

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Salt Composition: Sorafenib

Expiry Date: 01/2028

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120 tablet

About The Product

  • Liver Cancer (Hepatocellular Carcinoma)
  • Kidney Cancer (Renal Cell Carcinoma)
  • Thyroid Cancer (Differentiated Thyroid Carcinoma)
  • Sorafenib 200mg Tablet is used to treat certain types of cancer (liver cancer, kidney cancer, and thyroid cancer).
  • This tablet belongs to a class of medication known as a tyrosine kinase inhibitor.
  • This medicine helps to stop the growth of cancerous cells.
  • Take this medicine orally. 

Uses


  • Liver Cancer (Hepatocellular Carcinoma)
  • Kidney Cancer (Renal Cell Carcinoma)
  • Thyroid Cancer (Differentiated Thyroid Carcinoma)

Side Effects

Sorafenib 200mg Tablet may cause certain side effects. Make sure to contact your healthcare professional if side effects occur after administration or last longer than usual.

  • Diarrhea 
  • Hand-foot skin reaction (painful blisters)
  • Fatigue
  • Hair loss
  • Weight loss
  • Rash
  • Abdominal pain 
  • Nausea
  • Loss of appetite
  • Hypertension

Dosage and Administration

  • ​Take Sorafenib 200mg Tablet orally on an empty stomach once a day.
  • Try not to miss your regular dosing schedule.
  • Take this medicine as prescribed by your medical advisor.
  • Do not crush or chew the tablet.
  • The dose is decided by a medical advisor according to your response to the treatment and your previous medical condition.
  • Regular monitoring of blood pressure is required during treatment with this medicine.
  • Keep yourself hydrated and maintain good nutrition while taking this medicine.

Mechanism of action

  • Sorafenat is a kinase inhibitor that decreases tumor cell proliferation in vitro.
  • Sorafenat inhibited the tumor growth of HCC, RCC, and DTC human tumor xenografts in immunocompromised mice.
  • Reductions in tumor angiogenesis were seen in models of HCC and RCC upon Sorafenat treatment, and increases in tumor apoptosis were observed in models of HCC, RCC, and DTC. 

Safety Advice

Alcohol
It is advisable not to consume alcohol while taking medicine.
Pregnancy
Do not take Sorafenib 200mg Tablet without consulting the doctor, in case of pregnancy.
Breast Feeding
Without a doctor's consultation, do not take this medicine if you're breastfeeding.
Driving
It is advisable not to drive or operate heavy machinery, you may feel dizzy as one of the side effects of the medicine.
Kidney
Do not consume Sorafenib 200mg Tablet without a doctor's consultation in case of kidney problems.
Liver
Share your medical history with the doctor in case of liver disease before taking this medicine.

Missed Doses

  • It is advisable not to miss a dose.
  • If you miss a scheduled dose of the Sorafenat tablet, contact your doctor immediately.

FAQs

This medication is used to treat a certain type of cancer (liver cancer, kidney cancer, and thyroid cancer). This tablet belongs to a class of medication known as a tyrosine kinase inhibitor.

This medicine helps to stop the growth of cancerous cells.

References

  • Pharmacokinetic and pharmacodynamic characteristics of sorafenib 200mg film‑coated tablets (sorafenat). (n.d.). Absorption, metabolism, and elimination profiles. medthority.com and PMC article summary.
  • Study 100554 (SHARP trial) and Study 11849: sorafenib versus placebo in hepatocellular carcinoma and renal cell carcinoma. (n.d.). Summary of product characteristics and pivotal trial data publications. medicines.org.uk [SmPC & EMA summary].
  • Suk, F. M., Wu, C. Y., Fang, C. C., Chen, T. L., & Liao, Y. J. (2023, August 9). β‑HB treatment reverses sorafenib resistance by shifting glycolysis‑lactate metabolism in HCC. Biomedicine & Pharmacotherapy. https://doi.org/10.1016/j.biopha.2023.115293
  • TARGET Phase III trial: sorafenib in advanced renal cell carcinoma. (n.d.). Trial summary data reporting median PFS, OS, and hazard ratios. medicines.org.uk [SmPC & EMA summary].

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