Telma ACT 40/5/12.5 mg Tablet

• Treats high blood pressure (Hypertension)
  

Telma ACT 40/5/12.5mg tablet cause several side effects that are easily manageable with certain treatment options. If any of the following symptoms persist or worsen consult the healthcare professional instantly:

• Fatigue (tiredness)
• Bradycardia
• Gastrointestinal disturbance
• Electrolyte imbalance
• The increased glucose level in the blood
• Postural hypotension
• Angioedema and urticaria
• Visual disturbance
• Breathlessness
• Muscle cramp
• Headache
• Dizziness
• Sleepiness
• Ankle swelling

• Doctor prescription is required while using Telma ACT 40/5/12.5mg tablet to ensure safe and effective treatment option.
• The tablet should be taken with or without food at the same time every day to enhance the effectiveness, maintain consistent blood pressure and reduce the risk of side effects.
• Do not crush, chew or break the tablet as it decrease the effectiveness of the medication and alter its absorption.
  ​

• Telma ACT 40/5/12.5mg tablet contains three drugs that lowers blood pressure by Angiotensin-II (constricts vessels), inhibiting calcium entry into muscles (relaxes vessels), and reducing excess fluid/sodium.
• Telmisartan(40mg) acts as an angiotensin II receptor blocker (ARB) which preventing vasoconstriction and narrowing of blood vessels. Amlodipine (5mg) is a calcium channel blocker that prevents calcium from entering vascular smooth muscle cells, causing blood vessels to relax and widen.
• Chlorthalidone (12.5mg) is a thiazide like diuretic that reducing fluid volume and improving blood flow.
  
  

• McClellan, K. J., & Markham, A. (1998). Telmisartan. Drugs, 56(6). https://pubmed.ncbi.nlm.nih.gov/9878991/
• Sharpe, M., Jarvis, B., & Goa, K. L. (2001). Telmisartan: a review of its use in hypertension. Drugs, 61(10), 1501-1529. https://pubmed.ncbi.nlm.nih.gov/11558835/
• Kuschnir, E., Acuña, E., Sevilla, D., Vasquez, J., Bendersky, M., Resk, J., & Glazer, R. (1996). Treatment of patients with essential hypertension: amlodipine 5 mg/benazepril 20 mg compared with amlodipine 5 mg, benazepril 20 mg, and placebo. Clinical therapeutics, 18(6), 1213-1224. https://pubmed.ncbi.nlm.nih.gov/9001838/
• Abernethy, D. R. (1989). The pharmacokinetic profile of amlodipine. American heart journal, 118(5), 1100-1103. https://pubmed.ncbi.nlm.nih.gov/2530866/ 
• Pareek, A. K., Messerli, F. H., Chandurkar, N. B., Dharmadhikari, S. K., Godbole, A. V., Kshirsagar, P. P., ... & Kumbla, M. M. (2016). Efficacy of low-dose chlorthalidone and hydrochlorothiazide as assessed by 24-h ambulatory blood pressure monitoring. Journal of the American College of Cardiology, 67(4), 379-389. https://pubmed.ncbi.nlm.nih.gov/26821625/​