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Tofajak 5mg Tablet

Tofajak 5mg Tablet

Prescription requiredRx Required

Salt Composition: Tofacitinib

Expiry Date: 01/2028

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60 tablet in Bottle

About The Product

Rheumatoid Arthritis

Tofajak 5mg tablet contains tofacitinib, an approved medication that falls under the category of Janus kinase inhibitors. It is used to treat adults with moderate to severe rheumatoid arthritis and psoriatic arthritis who have failed methotrexate.


With its ability to inhibit JAK enzymes, Tofajak decreases the inflammatory process caused by the immune system, leading to the relief of arthritis symptoms and joint inflammation. Besides arthritis, Tofajak is also recommended for treating ulcerative colitis in adults. Tofajak comes in the form of oral tablets with a dose of 5mg.

Uses

  • Treatment of Ulcerative colitis
  • Treatment of Ankylosing spondylitis
  • Treatment of Rheumatoid arthritis
  • Treatment of Psoriatic arthritis

Safety Advice

Alcohol

Do not consume alcohol while taking Tofajak 5mg tablet.

Pregnancy

Do not take Tofajak 5mg tablet without consulting the doctor, in case of pregnancy.

Breast Feeding

Do not take Tofajak 5mg tablet if you're breastfeeding. Consultation of the doctor is advised.

Driving

It is advisable not to drive or operate heavy machinery, you may feel dizzy as one of the side effects of Tofajak 5mg tablet.

Kidney

Do not take Tofajak 5mg tablet without a doctor's consultation in case of kidney problems.

Liver

Share your medical history with the doctor in case of liver disease before taking Tofajak 5mg tablet.

Side Effects

Following are the possible side effects that can occur during your treatment with tofajak 5mg tablet. Contact your medical practitioner immediately if any of the above-mentioned side effects appear.

  • Diarrhea
  • Headache
  • Dizziness
  • Drowsiness
  • Cough
  • Trouble breathing
  • Night sweats
  • Sore throat
  • Fever
  • Chills
  • Stomach pain
  • Nausea
  • Vomiting
  • Itching

How To Use

  • The dose of Tofajak 5mg tablet is recommended by the healthcare professional as per the patient’s health and requirements.
  • These tablets are indicated for oral use.
  • Swallow the tablets as a whole with water.

How It Works

  • Tofacitinib 5 mg, the active ingredient of Tofajak tablets, is a reversible Janus kinase (JAK) inhibitor that primarily targets JAK1 and JAK3, thereby blocking cytokine-mediated intracellular signaling and reducing inflammation in autoimmune diseases.
  • By inhibiting JAKs, this compound actively hinders the phosphorylation and activation of STATs.
  • The JAK-STAT signaling pathway is involved in the transcription of cells that are involved in hematopoiesis, and immune cell function.
  • Tofajak 5mg Tablet works therapeutically by causing inhibition against the JAK-STAT pathway to reduce the inflammatory response in the body.
  • However, there is evidence to suggest that it may also achieve efficacy through other pathways.​

Missed Doses

  • If you miss a dose of Tofajak 5mg tablets, make sure to call your healthcare professional to learn the ways of managing the missed dose.
  • Ask your doctor for methods of coping.

FAQs

Tofajak 5mg tablet are a prescription regimen comprising Tofacitinib.

It is used in the treatment of patients suffering from severely active rheumatoid arthritis and psoriatic arthritis.

References

  • Efficacy and safety of tofacitinib in Chinese patients with active psoriatic arthritis: phase III, randomized, double blind, placebo-controlled study. (2023). BMJ / PubMed - https://pubmed.ncbi.nlm.nih.gov/36720560/
  • Efficacy and safety of tofacitinib in rheumatoid arthritis by previous treatment: post hoc analysis of phase II/III trials. (2024). Arthritis Research & Therapy - https://pubmed.ncbi.nlm.nih.gov/37919780/
  • Ekin, A., Misirci, S., İldemir, S., Coskun, B. N., Yagiz, B., Dalkilic, E., & Pehlivan, Y. (2024, November 18). Efficacy and safety of tofacitinib in rheumatoid arthritis: Nine years of real-world data. Clinical and Translational Science, 17(11), e70084. https://doi.org/10.1111/cts.70084
  • Integrated safety analysis of tofacitinib from Phase 2 and 3 trials of patients with ankylosing spondylitis. (2024). Advances in Rheumatology, 64, 87 - https://pubmed.ncbi.nlm.nih.gov/39695887/

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