Zerodol MR Tablet

• Zerodol MR Tablet is a pain-relieving medicine with Aceclofenac (100mg) and Tizanidine (2mg) as an active ingredient. It is prescribed to treat pain due to muscle spasms. It improves the movement of muscles and provides relief from pain and discomfort associated with muscle spasms.
• This is a non-steroidal anti-inflammatory drug (NSAID). It should be taken in dose and duration as advice by the doctor. Don't take more than the recommended dose.
  
  

• Pain due to muscle spasm

Side effects are unwanted symptoms that can occur from any medical treatment. Like other medications, the Zerodol MR Tablet can also have adverse effects on the body, most of which resolve without the need for medical attention.
Some common side effects include:

• Nausea
• Sleepiness
• Vomiting
• Heartburn
• Diarrhea
• Loss of appetite
• Dryness in mouth

Seek medical attention in case of any unusual or severe side effects immediately.

Doctor determines the exact dose and duration with Zerodol MR Tablet as per the overall health condition of the patient. This tablet should be taken with food or after food, but at the fix time every day to get effective results. Don't miss a dose or overdose on the medicine. Swallow it as a whole with a glass of water and do not crush, chew, or open it.

• Zerodol MR Tablet is a pain-relieving medicine with Aceclofenac (100mg) and Tizanidine (2mg) as an active ingredient. This is a non-steroidal anti-inflammatory drug (NSAID). Aceclofenac acts by inhibiting the secretion of a few chemical messengers that are responsible for pain and inflammation (redness and swelling).
• Tizanidine is known as a muscle relaxant that works on the centers in the brain & spinal cord to provide relieve from muscle stiffness or spasm and to improve pain as well as movement of muscles.
  
  

• Balap, A. R., Khidse, A. S., Prasad, D. V., Jadhav, S. B., Ingale, P. L., & Chaudhari, P. D. (2011). Simultaneous spectrophotometric estimation of aceclofenac and tizanidine hydrochloride in combined tablet dosage form. Research journal of Pharmacy and Technology, 4(3), 461-464. https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2011-4-3-20
• Belal, F., Omar, M. A., Derayea, S., Hammad, M. A., Zayed, S., & Saleh, S. F. (2018). Simultaneous determination of tizanidine, nimesulide, aceclofenac and paracetamol in tablets and biological fluids using micellar liquid chromatography. Journal of Chromatographic Science, 56(3), 233-241. https://pubmed.ncbi.nlm.nih.gov/29236980/
• Borse, S., Ahmad, S., & Tatiya, A. U. (2021). Method Development and Validation for the Simultaneous Estimation of Tizanidine and Aceclofenac by (UHPLC) RP-HPLC in Bulk and Tablet Dosage Forms. Journal of Pharmaceutical Sciences and Research, 13(8), 502-507. https://pharmainfo.in/jpsr/Documents/Volumes/vol13issue08/jpsr13082113.pdf
• Hardik R, P., & Narajji, C. (2011). Method development and validation for simultaneous estimation of Aceclofenac, Paracetamol and Tizanidine in pharmaceutical dosage form by analytical method (Doctoral dissertation, Acharya & BM Reddy College of Pharmacy (ABMRCP)). http://lrc.acharyainstitutes.in:8080/jspui/handle/123456789/6639
• Pareek, A., Chandurkar, N., Chandanwale, A. S., Ambade, R., Gupta, A., & Bartakke, G. (2009). Aceclofenac–tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone. European Spine Journal, 18(12), 1836-1842. https://pubmed.ncbi.nlm.nih.gov/19421791/