Z-PAC

Mfd. by :- RPG Life sciences Ltd (Fulfilled By : Magicine Pharma)

Z-pac

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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PACKAGE

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Brand name- Z-pac 

Generics- Paclitaxel 

Manufacturer- RPG Life sciences  Ltd.  

Dosage form- Injection 

Route of Administration- Intravenous (IV) 

Strength- 260mg 

Composition- Paclitaxel 

Packaging- vial 

Indication- non-small cell lung cancer (NSCLC) , Breast cancer, Ovarian cancer and pancreatic cancer. 

Storage- Do not store above 25°C. Keep the vial save protect from light. 

After dilution medicine store in a refrigerator (2 to 8°C) for no more than 24 hours 

Class of drug- Taxane derivative 

Mechanism of Action 

 It do its action by interfering with microtubule structures which assist the cancer cells to divide and multiply. This decreases the growth of cancer cells and eventually kills them. 

Side effects- 

 Side effects of Z-Pac include fever, low blood cell counts, feeling weak or tired, bleeding, trouble breathing, hair loss, numbness or tingling, swelling in your face, hands, or feet, sores or white patches in or around your mouth, joint or muscle pain, nausea, vomiting, diarrhea and mild redness or tenderness where the medicine was injected. 

Pharmacodynamics 

It is study of drug effects and what the medicine does to the body 

Z-Pac has different pharmacodynamic effects in each disorder like breast cancer, ovarian cancer and advanced non-small cell lung carcinoma. 

Pharmacokinetics 

Study of what body does to the medicine.After oral administration of a single dose, the time of peak concentration, Tmax, was between 1 and 4 hr. 

Minimum effect concentration (MEC) 

Minimum concentration of medicine in blood required for producing the therapeutic effects. Its predefined therapeutic range is not known.  

Minimum toxic concentration (MTC) 

Minimum concentration of medicine in blood above which toxic or adverse effects are precipitated. Its MTC range is not known. 

Bioavailability rate 

Bioavailability is low (about 30%). 

Shelf life  

Shelf life is the time period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at time of manufacture. 

Its shelf life is 12 months. 

Usage 

 Which disease area  

non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, and pancreatic cancer 

Alternate brands 

Oncotaxel 260mg Injection- Sun Pharmaceutical Industries Ltd 

Cytax 260mg Injection- Intas Pharmaceuticals Ltd 

Petaxel 260mg Injection- Biochem Pharmaceutical Industries 

Tortaxel 260mg Injection- Torrent Pharmaceuticals Ltd 

Precaution 

It is an injection to be taken under the directions of a medical professional. 

Side effects 

Common side effects 

  • Nausea 

  • Vomiting 

  • Weakness 

  • Low blood platelets 

  • Rash 

  • Upper respiratory tract infection 

  • Urinary tract infection 

  • Bleeding 

  • Anemia (low number of red blood cells) 

  • Flushing (sense of warmth in the face, ears, neck and trunk) 

  • Hair loss 

  • Decreased blood pressure 

  • Peripheral neuropathy (tingling and numbness of feet and hand) 

  • Diarrhea 

  • Decreased white blood cell count (neutrophils 

Serious side effects 

  •  Neutropenia 

  • Difficult or painful urination 

  • Dizziness when getting up suddenly from a sitting position 

  • Fever and chills 

  • Pale skin 

  • Allergic Skin Reaction 

  • Mouth ulcers 

  • Difficulty in breathing 

  • Chest discomfort 

Dosage 

Missed dose 

It is advised not to miss any dose of this medicine. If you missed any dose, contact your doctor immediately 

Overdose 

Get the emergency medical treatment and contact your physician

Warnings 

Before taking Z-Pac, tell the doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using

Cautions 

It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it.

 

 

 

Q What is Z-Pac 

Z-Pac Injection is an anticancer medicine, used in chemotherapy to treat a number of cancers. Primarily for the treatment of breast cancer and ovarian cancer 

Q How Z-Pac works 

It do its action by interfering with microtubule structures which assist the cancer cells to divide and multiply. This decreases the growth of cancer cells and eventually kills them. 

Q What are the side effects 

Some common side effects include nausea, vomiting, and weakness. It may also cause serious side effects such as swelling of hands, lips, hair loss, and weight gain.  

Q What should I avoid while receiving this medicine 

No information is available. 

Q How to use Z-Pac 

Z-Pac is given as by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. 

Q What happens when I miss a dose 

It is advised not to miss any dose of this medicine. If you missed any dose, contact your doctor immediately 

Q Does this medicine effects liver function 

There is no affects on the liver functions but consult your doctor if you have liver related disorders. 

Q Can I drive after taking this medicine 

Do not drive if you have any symptoms that affect your ability to concentrate and react. 

Q Can I take this medicine during pregnancy 

Z-Pac is not safe to use during pregnancy as there is proven evidence of risk to the developing baby.  

Q Can I take this medicine during breast-feeding 

Z-Pac is not safe to use during breastfeeding. 

Q Can I consume Alcohol while taking this medicine 

It is not safe to consume alcohol while taking Z-Pac. 

Q Does it affect kidney functions 

There is no affects on the kidney functions but talk to the doctor if you have any kidney disease. 

Q What are the storage conditions 

Do not store above 25°C. Keep the vial save protect from light. 

After dilution medicine store in a refrigerator (2 - 8°C) for no more than 24 hours. 

Interactions 

1. Medicine interaction 

  • Clozapine 
  • Diltiazem 
  • Atorvastatin 
  • Live vaccines 

2. Disease interaction 

Gastrointestinal Diseases (especially peptic ulcer diseases) 

Eye disorder ( primary keratitis, ulcerative keratitis, conjunctivitis, etc) 

Hepatic impairment (extreme caution in a patient suffering from liver diseases 

3.  Alcohol interaction 

Alcohol interaction is unknown, but don’t consume alcohol while taking Z-pac  

4. Food interaction 

Information not available. 

Contraindications 

It includes severe Hypersensitivity

Above Content has been reviewed by Professionals