ERLONAT

Mfd. by :- NATCO (Fulfilled By : Magicine Pharma)

Erlonat

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand name- Erlonat 

Generics- Erlotinib Hydrochloride 

Manufacturer- NATCO pharma  

Dosage form- Tablet 

Route of Administration- oral 

Strength- 100, 150mg 

Composition- Erlotinib Hydrochloride 

Packaging- bottle 

Indication- non-small cell lung cancer (NSCLC) and pancreatic cancer. 

Storage- Store at room temperature (10-30°C) 

Class of drug- Kinase inhibitor 

Mechanism of Action 

It belongs to a class of medications called kinase inhibitors. It works by blocking the action of abnormal protein that signals cancer cells to multiply. This in turn helps to slow or inhibit the spread of cancer cells 

Side effects- 

Rashes in the majority of patients. 

Diarrhea, Loss of appetite, Fatigue, Partial Hair Loss. 

Rarely, ingrown hairs, like eyelashes 

Pharmacodynamics 

It is study of drug effects and what the medicine does to the body 

It inhibits the intracellular phosphorylation of tyrosine kinase associated with epidermal growth factor (EGFR). As the specificity of inhibition with respect to other tyrosine kinase receptors has not been fully characterized. EGFR is also expressed on the cell surface of normal cells and cancer cells 

Pharmacokinetics 

Study of what body does to the medicine.Erlonat is around 60% absorbed after administration into the body and its bio availability is increased by food to almost100%. Its half-life is 36 hours and it is cleared majorly by CYP3A4 enzyme present in the body. 

Minimum effect concentration (MEC) 

Minimum concentration of medicine in blood required for producing the therapeutic effects. Its predefined therapeutic MEC is (0.8μg/ml)   

Minimum toxic concentration (MTC) 

Minimum concentration of medicine in blood above which toxic or adverse effects are precipitated. Its MTC is 1.25μg/ml 

Bioavailability rate 

After oral administration, the medicine archived approximately 60% bioavailability, with administration with food enhancing bioavailability to upwards of 100% 

Shelf life  

Shelf life is the time period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at time of manufacture. 

Its shelf life is 2years 

Substitutes 

  • Tarceva  

  • Carac 

 
Alternate brands 

  • Erlocip by Cipla Ltd. 

  • Erlotib 150mg Tablet by Intas. 

  • Zyceva 150mg Tablet by Zydus. 

  • Erleva 100 mg/150 mg by Glenmark. 

  • Erlotirel 100 mg/150 mg by Reliance life Sciences. 

Precaution 

Consult your doctor before taking this medicine, if you: 

Are allergic to ERLONAT 150MG, or any of the ingredients of this medicine or having a severe liver disease or severe kidney disease 

If one uses contact lenses and/or have a history of eye problems such as severe dry eyes  
Side effects 

Common side effects 

  • Abdominal pain 

  • Bone pain 

  • Breathlessness 

  • Constipation 

  • Cough 

  • Diarrhea 

  • Fatigue 

  • Fever 

  • Infection 

  • Muscle pain 

  • Nausea 

  • Rash 

  • Stomatitis (Inflammation of the mouth) 

  • Vomiting 

  • Weight loss 

Serious side effects 

Fatigue, loss of appetite, partial hair loss, diarrhea, mouth sores, vomiting, rashes, weight loss, dry skin, eye irritation, weight decrease, infection, edema, pyrexia, and constipation, bone pain, dyspnea, stomatitis and myalgia.

Dosage 

Missed dose 

If the patient misses a dose of medicine, skip it and continue with the normal schedule. No need to double the dose 

Overdose 

Get the emergency medical treatment and contact your physician

Usage 

Which disease area  
non-small cell lung cancer (NSCLC) and pancreatic cancer 
 

Warnings 

General warning and precautions 

The medicine causes skin rash, dryness, or other irritation. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. 

Stop using skin products that cause dryness or irritation, such as acne medications, harsh soaps or skin cleansers, or skin products that have alcohol. 

Cautions 

It is usually taken on an empty stomach once a day, at least 1 hour before or 2 hours after eating a meal or snack. Take erlonat at around the same time every day. 

Q What is Erlonat?

Erlonat 150 Tablet is an anticancer medicine used for the treatment of non-small cell lung cancer. It is also used in a combination with gemcitabine to treat the pancreatic cancer.  

Q How Erlonat works?

Epidermal growth factor receptors (EGFR) are expressed on the lung cancer cell surfaces that regulate their growth. This medicine works by binding the chemical messenger, EGFR, thus inhibits the cancer signaling pathways. This is how the medicine inhibit further growth of the cancer cells. 

Q What are the side effects?

Side Effects of Erlonat are Abdominal pain, Bone pain, Breathlessness, Constipation, Cough, Diarrhea, Edema (swelling), Fatigue, Fever, Infection, Muscle pain, Nausea, Rash, Stomatitis (Inflammation of the mouth), Vomiting, Weight loss. 

Q In what strength it is available?

It is available in 100 and 150 mg 

Q What should I avoid while receiving this medicine?

Avoid grape juice and smoking while taking the medication 

Q How to use Erlonat?

Erlonat 150 Tablet is a pill to be administered orally, once a day without food as prescribed by the concerned specialist. Take Erlonat 150 Tablet empty stomach, at least 1 hour before or 2 house after meals. Take it the same time each day so that you remember when to take it 

Q What happens when I miss a dose?

If you miss a dose of medicine, skip it and continue with the normal schedule. No need to double the dose 

Q Does this medicine affects liver function?

There is no effects on liver functions but consult your doctor if you have liver-related disorders. 

Q Can I drive after taking this medicine?

Do not drive if you have any symptoms that affect your ability to concentrate and react. 

Q Can I take this medicine during pregnancy?

Erlonat is not safe to use during pregnancy as there is proven evidence of risk to the developing baby.  

Q Can I take this medicine during breast-feeding?

Erlonat is probably not safe to use during breastfeeding. 

Q Can I consume Alcohol while taking this medicine? 

It is not known, consult your doctor 

Q Can I consume milk while taking this medicine? 

Information is not available 

Q Does it affect kidney functions ?

There is no affects on the kidney functions 

Q What are the storage conditions? 

Store the medicine at room temperature (10-30°C) 

Interactions 

Medicine interaction 

  1. Atazanavir 

  1. Ciprofloxacin 

  1. Carbamazepine 

  1. Clarithromycin 

  1. Lansoprazole 

  1. Pantoprazole 

     7. Fluvoxamine 

Disease interaction 

Gastrointestinal Diseases (especially peptic ulcer diseases) 

Eye disorder ( primary keratitis, ulcerative keratitis, conjunctivitis, etc) 

Hepatic impairment (extreme caution in patients suffering from liver diseases. 

Alcohol interaction 

Alcohol interaction is unknown, consult your doctor 

 Food interaction 

The patient should also avoid grapefruit and grapefruit juice while taking the medicine. Food and grapefruit raise the levels of erlonat in your body and lead to increased side effects. 

Contraindications 

It includes Hypersensitivity 

Above Content has been reviewed by Professionals