Mfd. by :- ARIAD (Fulfilled By : Magicine Pharma)
Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.
Brand name - Iclusig
Generic name - Ponatinib
Salt composition - Ponatinib
Manufacturer - ARIAD
Dosage form - Oral (tablet)
Packaging - Bottle
Indication - Blood cancer
Storage - Stored at room temperature.
Strength - 15 mg, 45 mg
Gender - Unisex
Prescription required - Yes
Iclusig (Ponatinib 45mg) tablet is used in the treatment of adults with leukaemia (cancer of
the white blood cells). It is used to treat the different stages of chronic myeloid
leukaemia (CML), namely chronic, accelerated and blast phases. It is also used in the
treatment of acute lymphoblastic leukaemia (ALL) in certain patients who are
‘Philadelphia-chromosome positive’, which means those patients whose genes have
rearranged themselves to form another special type of a chromosome called
‘Philadelphia-chromosome’. This chromosome leads to the development of Leukaemia.
Ponatinib is a multi-target kinase inhibitor. Its primary cellular target is the Bcr-Abl
tyrosine kinase protein which is active and works to promote the progression of CML.
This protein arises from the fused Bcr and Abl gene which is commonly known as the
Philadelphia chromosome. Ponatinib is especially useful in the treatment of resistant
CML because it works to inhibit the tyrosine kinase activity of Abl and T315I mutant
kinases. The T315I mutation highly confers resistance in cells. It prevents other Bcr-Abl
inhibitors from binding to the Abl kinase. Some other targets that ponatinib inhibits are
members of the VEGFR, PDGFR, FGFR, EPH receptors and SRC families of kinases, and
KIT, RET, TIE2, and FLT3.
This medicine is not indicated to the patients who have a known allergy to any of the
ingredients of this medicine.
● Skin rash
● Chest pain
● Fever
● Nausea
● Joint or/and muscle pain
● Dry skin
● Constipation
● Weakness
● Drowsiness
● Cough
● Shortness of breath
● Fainting
● Chills
● Confusion
● Mood changes
● Blurred vision
● Unusual bleeding
● Back pain
● Yellowing skin
● Irregular heart rate
Take the dose exactly as your healthcare provider tells you. Do not increase or decrease
the dose strength as per your own wish. Do not crush, chew or break the tablet.
When you miss a dose, make sure to tell your healthcare provider regarding the same to
get proper guidance. Do not try to double the dose strength in order to catch up.
Seek emergency medical support.
Iclusig (Ponatinib) tablet is used in the treatment of:
● chronic myeloid leukaemia, and
● acute lymphoblastic leukaemia.
● Take the dose exactly as your healthcare provider tells you. Do not increase or
decrease the dose strength as per your own wish. Do not crush, chew or break
the tablet.
● Do tell your healthcare provider beforehand about your medical condition and
medical history, along with the list of medicines you already take.
● In patients with kidney disease, administer this medicine with utmost caution.
● In patients with liver disease, administer this medicine with utmost caution.
● During pregnancy/breastfeeding, take it only if your healthcare provider
prescribes it. Make sure to talk about the potential risks and benefits.
Q1- What is the Iclusig tablet used for?
A- Iclusig tablet is used in the treatment of chronic myeloid leukaemia, and acute
lymphoblastic leukaemia.
Q2- How should I take the Iclusig tablet?
A- Take the dose exactly as your healthcare provider tells you. Do not increase or
decrease the dose strength as per your own wish. Do not crush, chew or break the
tablet.
Q3- What are the side effects of the Iclusig tablet?
A- There are some effects such as fever, chills, insomnia, anaemia, chest pain, back
pain, muscle pain and vomiting. There can be other side effects also. Kindly consult
your healthcare provider regarding the side effects you experience.
Q4- What are the storage conditions for Iclusig tablets?
A- Stored at room temperature. Keep it away from pets.
Q5- Can I drive after consuming this medicine?
A- Drive only if you feel well after taking this medicine.
Q6- Can I drink alcohol while consuming this medicine?
A- Avoid drinking alcohol with this medicine.
Q7- Can I take this tablet during pregnancy?
A- Take it only if your healthcare provider prescribes it. Make sure to talk about the
potential risks and benefits.
Q8- Can I take this tablet during breastfeeding?
A- Take it only if your healthcare provider prescribes it. Make sure to talk about the
potential risks and benefits.
Q9- Can I take this medicine if I have liver disease?
A- In patients with liver disease, administer this medicine with utmost caution.
Q10- Can I take this medicine if I have kidney disease?
A- In patients with kidney disease, administer this medicine with utmost caution.
Q11- What should be done if I miss a dose?
A- When you miss a dose, make sure to tell your healthcare provider regarding the same
to get proper guidance. Do not try to double the dose strength in order to catch up.
Q12- What should be done if I overdose?
A- Seek emergency medical support.
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