ICLUSIG

Mfd. by :- ICLUSIG (Fulfilled By : Magicine Pharma)

Iclusig

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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DESCRIPTION

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PACKAGE

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Brand name - Iclusig

Generic name - Ponatinib

Salt composition - Ponatinib

Manufacturer - ARIAD

Dosage form - Oral (tablet)

Packaging - Bottle

Indication - Blood cancer

Storage - Stored at room temperature.

Strength - 15 mg, 45 mg

Gender - Unisex

Prescription required - Yes

Description

Iclusig (Ponatinib) tablet is used in the treatment of adults with leukaemia (cancer of

the white blood cells). It is used to treat the different stages of chronic myeloid

leukaemia (CML), namely chronic, accelerated and blast phases. It is also used in the

treatment of acute lymphoblastic leukaemia (ALL) in certain patients who are

‘Philadelphia-chromosome positive’, which means those patients whose genes have

rearranged themselves to form another special type of a chromosome called

‘Philadelphia-chromosome’. This chromosome leads to the development of Leukaemia.

Pharmacodynamics

Ponatinib is a multi-target kinase inhibitor. Its primary cellular target is the Bcr-Abl

tyrosine kinase protein which is active and works to promote the progression of CML.

This protein arises from the fused Bcr and Abl gene which is commonly known as the

Philadelphia chromosome. Ponatinib is especially useful in the treatment of resistant

CML because it works to inhibit the tyrosine kinase activity of Abl and T315I mutant

kinases. The T315I mutation highly confers resistance in cells. It prevents other Bcr-Abl

inhibitors from binding to the Abl kinase. Some other targets that ponatinib inhibits are

members of the VEGFR, PDGFR, FGFR, EPH receptors and SRC families of kinases, and

KIT, RET, TIE2, and FLT3.

Contraindications

This medicine is not indicated to the patients who have a known allergy to any of the

ingredients of this medicine.

Side effects

● Skin rash

● Chest pain

● Fever

● Nausea

● Joint or/and muscle pain

● Dry skin

● Constipation

● Weakness

● Drowsiness

● Cough

● Shortness of breath

● Fainting

● Chills

● Confusion

● Mood changes

● Blurred vision

● Unusual bleeding

● Back pain

● Yellowing skin

● Irregular heart rate

Dosage

Normal dose

Take the dose exactly as your healthcare provider tells you. Do not increase or decrease

the dose strength as per your own wish. Do not crush, chew or break the tablet.

Missed dose

When you miss a dose, make sure to tell your healthcare provider regarding the same to

get proper guidance. Do not try to double the dose strength in order to catch up.

Overdose

Seek emergency medical support.

Usage of medicine

Iclusig (Ponatinib) tablet is used in the treatment of:

● chronic myeloid leukaemia, and

● acute lymphoblastic leukaemia.

Warning and precautions

● Take the dose exactly as your healthcare provider tells you. Do not increase or

decrease the dose strength as per your own wish. Do not crush, chew or break

the tablet.

● Do tell your healthcare provider beforehand about your medical condition and

medical history, along with the list of medicines you already take.

● In patients with kidney disease, administer this medicine with utmost caution.

● In patients with liver disease, administer this medicine with utmost caution.

● During pregnancy/breastfeeding, take it only if your healthcare provider

prescribes it. Make sure to talk about the potential risks and benefits.

FAQs

Q1- What is the Iclusig tablet used for?

A- Iclusig tablet is used in the treatment of chronic myeloid leukaemia, and acute

lymphoblastic leukaemia.

Q2- How should I take the Iclusig tablet?

A- Take the dose exactly as your healthcare provider tells you. Do not increase or

decrease the dose strength as per your own wish. Do not crush, chew or break the

tablet.

Q3- What are the side effects of the Iclusig tablet?

A- There are some effects such as fever, chills, insomnia, anaemia, chest pain, back

pain, muscle pain and vomiting. There can be other side effects also. Kindly consult

your healthcare provider regarding the side effects you experience.

Q4- What are the storage conditions for Iclusig tablets?

A- Stored at room temperature. Keep it away from pets.

Q5- Can I drive after consuming this medicine?

A- Drive only if you feel well after taking this medicine.

Q6- Can I drink alcohol while consuming this medicine?

A- Avoid drinking alcohol with this medicine.

Q7- Can I take this tablet during pregnancy?

A- Take it only if your healthcare provider prescribes it. Make sure to talk about the

potential risks and benefits.

Q8- Can I take this tablet during breastfeeding?

A- Take it only if your healthcare provider prescribes it. Make sure to talk about the

potential risks and benefits.

Q9- Can I take this medicine if I have liver disease?

A- In patients with liver disease, administer this medicine with utmost caution.

Q10- Can I take this medicine if I have kidney disease?

A- In patients with kidney disease, administer this medicine with utmost caution.

Q11- What should be done if I miss a dose?

A- When you miss a dose, make sure to tell your healthcare provider regarding the same

to get proper guidance. Do not try to double the dose strength in order to catch up.

Q12- What should be done if I overdose?

A- Seek emergency medical support.

Above Content has been reviewed by Professionals