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Instgra 50mg Tablet

Instgra 50mg Tablet

Prescription requiredRx Required

Salt Composition: Dolutegravir

Expiry Date: 01/2028

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$37.94

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30 tablets

About The Product

HIV infection

  • The contents of Instgra 50 mg include dolutegravir, which acts as an antiretroviral agent.
  • It is used in the treatment of patients infected with HIV, in both adult and child patients weighing 14-20 kg.
  • As an integrase inhibitor, this drug inhibits the replication of the virus within the body, hence reducing its concentration while increasing the count of CD4 cells to enhance the immune system of the patient.
  • It is important to note that this drug does not offer a cure for the infection; rather, it is essential in the prolonged treatment process and is usually administered either once or twice a day, regardless of whether food was taken or not.
  • Consistency in the intake of this drug is crucial, since missing any doses might make the medication less effective, leading to resistance.
  • The intake of antacids or calcium supplements should also be avoided around the period of administration of the drug due to possible interactions.

Uses

HIV infection

Side Effects of Instgra 50mg Tablet

The following are the possible side effects that can occur during your treatment with Instgra 50mg Tablet. Contact your medical practitioner immediately if any of the below-mentioned side effects appear.

  •  Nausea
  • Fatigue / tiredness
  • Muscle pain / cramps
  • Joint pain
  • Headache
  • Rash / itching
  •  Abnormal dreams
  • Insomnia
  •  Anxiety
  • Depression
  • Dizziness
  • Stomach pain / discomfort
  • Diarrhea
  •  Weight gain
  •  Edema / swelling (face, legs, ankles, feet, body)
  •  Allergic reactions (swelling, fever)
  • Infections / inflammation
  • Fever
  • Lack of sleep
  • Increased liver enzymes
  • Liver inflammation / liver failure
  • Decreased red and white blood cell counts
  • Heart failure
  • Gastrointestinal disorders
  • Hypothyroidism


Dosage and Administration

  • This is an oral prescription medicine.
  • The dose and period of treatment using the medicine will depend on various aspects of your condition, which will be determined by your physician.
  • Always use Instgra 50mg Tablet according to your physician’s prescription.
  • You can swallow the tablet either with or without food.
  • Ensure that you do not crush, bite, or chew the tablet.

Mechanism of action

  • Instgra 50mg Tablet, comprising Dolutegravir, is an HIV-1 antiviral agent.
  • It works to inhibit HIV integrase and binds to the active site. It blocks the strand transfer step of retroviral DNA integration in the host cell.
  • During the clinical trials, it was indicated that Dolutegravir has a tight binding and longer dissociative half-life.
  • Therefore, it is indicated in combination with other antiretroviral agents for the treatment of patients with HIV-1 infection, provided their age is 12 or above and their present weight is at least 40 kg.

Safety Advice

Alcohol
Avoid consuming alcohol while taking Instgra 50mg Tablet, since the use of alcohol will predispose one to liver problems.
Pregnancy
Do not take Instgra 50mg Tablet without consulting the doctor, in case of pregnancy. Women of childbearing potential should be aware that dolutegravir carries a risk of neural tube defects in infants, and this risk must be carefully considered before starting treatment.
Breast Feeding
Do not take Instgra 50mg Tablet if you're breastfeeding. Consultation of the doctor is advised.
Driving
It is advisable not to drive or operate heavy machinery, you may feel dizzy as one of the side effects of Instgra 50mg Tablet.
Kidney
Do not take Instgra 50mg Tablet without a doctor's consultation in case of kidney problems.
Liver
Do not take Instgra 50mg Tablet without a doctor's consultation in case of liver problems.

Missed Doses

  • If you miss a dose, it is advisable to consult your healthcare provider to get the needed help.
  • Also, make sure to not double the dose strength to catch up.

FAQs

Instgra (Dolutegravir 50mg) tablet prescribed for the treatment of HIV (Human Immunodeficiency Virus) infection.


References

  • Dravid, P., Elica K., Sharma, S., Gupta, A., Roy, A., Basu, S., Singh, S. (2022). A Phase IV study on safety, Tolerability, and efficacy of dolutegravir, lamivudine, and tenofovir disoproxil fumarate in treatment‑naïve adult Indian patients living with HIV‑1. Clinical Infectious Diseases.Published online - https://pubmed.ncbi.nlm.nih.gov/35975180/
  • Marchand, C. (2012). The elvitegravir Quad pill: the first once-daily dual-target anti-HIV tablet. Expert opinion on investigational drugs, 21(7), 901-904. Gandhi Medicos. (2024). Navigating HIV management with Instgra Tablet: What you need to know. Gandhi Medicos Blog. Retrieved from  https://www.gandhimedicos.in/blog/understanding‑instgra‑tablet/
  • Panel on Antiretroviral Guidelines for Adults and Adolescents. (2024). Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Department of Health and Human Services Services. Retrieved from https://clinicalinfo.hiv.gov/en/guidelines/adult-and-adolescent-arv
  • Dravid, A., Morkar, D., Prasad, D., Ramapuram, J. T., Patel, K. V., Naik, K. S., Hegde, S. (2022). A phase IV study on safety, tolerability, and efficacy of dolutegravir, lamivudine, and tenofovir disoproxil fumarate in treatment-naïve adult Indian patients living with HIV-1. Pragmatic and Observational Research, 13, 75–84. - https://doi.org/10.2147/POR.S361907
  • Walmsley, S. L., Antela, A., Clumeck, N., Duiculescu, D., Eberhard, A., Gutiérrez, F., … Schapiro, J. M. (2013). Dolutegravir plus abacavir–lamivudine for the treatment of HIV-1 infection. New England Journal of Medicine, 369(19), 1807–1818 - https://doi.org/10.1056/NEJMoa1215541

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