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Tafero 25mg Tablet

Tafero 25mg Tablet

Prescription requiredRx Required

Salt Composition: Tenofovir Alafenamide

Expiry Date: 01/2028

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30 tablet

About The Product


  • Chronic Hepatitis B Treatment
  • HIV Management
  • Tafero 25mg Tablet, comprising Tenofovir Alafenamide, is an antiviral medicine.
  • It is prescribed for the treatment of HIV (Human Immunodeficiency Virus) infection and chronic Hepatitis B Virus (HBV) infection.
  • It works to slow or stop the multiplication of the virus in the body and helps to clear the infection.
  • It is advisable to take this medicine exactly as prescribed by the healthcare provider for better efficacy without increasing or decreasing the dose strength.

Uses

Tafero 25mg Tablet is used in the treatment of:

  • Chronic Hepatitis B Treatment
  • HIV Management

Side Effects

Monitor renal function and bone density during long-term therapy. The following are the possible side effects that can occur during your treatment with Tafero. Contact your medical practitioner immediately if any of the mentioned side effects appear.

  • Headache
  • Fever
  • Diarrhea
  • Vomiting
  • Nausea
  • Skin rash
  • Itching
  • Chills
  • Dizziness
  • Cough
  • Abdominal pain
  • Lactic acidosis

Dosage and Administration

  • Tafero (Tenofovir Alafenamide) tablet is available in the strength of 25 mg in the form of tablets for oral administration.
  • It is a prescription medicine that helps to slow down the multiplication of the virus in the body.
  • However, this medicine is not a permanent cure for HIV. It is advisable not to skip a dose or change the dose strength.
  • Swallow the tablet as a whole with water, without breaking, cutting, or chewing it.
  • Take it according to the doctor's advice.

Mechanism of action

  • Tafero 25mg Tablet is an antiviral drug. It is a phosphonamidate prodrug of tenofovir (2’-deoxyadenosine monophosphate analog).
  • Tenofovir Alafenamide enters primary hepatocytes by passive diffusion and by the hepatic uptake transporters OATP1B1 and OATP1B3.
  • It is converted to Tenofovir through hydrolysis primarily by carboxylesterase 1 (CES1) in primary hepatocytes.
  • Tenofovir is phosphorylated by cellular kinases to the pharmacologically active metabolite Tenofovir Diphosphate.
  • Tenofovir Diphosphate works to inhibit HBV replication through incorporation into viral DNA by the HBV reverse transcriptase, which results in DNA chain termination.

Safety Advice

Alcohol

Do not consume alcohol while taking Tafero.

Pregnancy

Do not take Tafero without consulting the doctor, in case of pregnancy.

Breast Feeding

Do not take Tafero if you're breastfeeding. Consultation of the doctor is advised.

Driving

It is advisable not to drive or operate heavy machinery, you may feel dizzy as one of the side effects of Tafero.

Kidney

Do not take Tafero without a doctor's consultation in case of kidney problems, as it causes renal toxicity.

Liver

Share your medical history with the doctor in case of liver disease before taking Tafero.

Missed Doses

  • It is advisable to not skip a dose.
  • If you miss a dose, make sure to take it as soon as you remember.
  • However, if it is already time for your next scheduled dose, skip the missed dose and take the scheduled dose.
  • Also, make sure to not increase the dose strength to catch up with the missed dose.

FAQs

Tafero 25mg Tablet is a prescription medicine.

It is used in the treatment of HIV (Human Immunodeficiency Virus) infection and chronic Hepatitis B Virus (HBV) infection.

References

  • Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre‑exposure prophylaxis (DISCOVER): Primary results from a randomised, double‑blind, multicentre, active‑controlled, phase 3, non‑inferiority trial. (2020). Lancet HIV, 7(10), e666–e676. Reddit+15PubMed+15ScienceDirect+15. https://pubmed.ncbi.nlm.nih.gov/32711800/
  • Efficacy and safety of tenofovir alafenamide versus tenofovir disoproxil fumarate given as fixed-dose combinations containing emtricitabine for treatment of HIV‑1 infection in virologically suppressed adults: A randomised, double‑blind, active‑controlled, phase 3 trial. (2016). Lancet HIV, 3(11), e536–e543. https://pubmed.ncbi.nlm.nih.gov/27036991/
  • Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV‑1 pre‑exposure prophylaxis: Week 96 results from a randomised, double‑blind, placebo‑controlled, phase 3 trial. (2021). Lancet HIV, 8(12), e734. PubMed. https://pubmed.ncbi.nlm.nih.gov/34197772/
  • Safety and pharmacokinetics of a tenofovir alafenamide fumarate–emtricitabine based oral antiretroviral regimen for prevention of HIV acquisition in women: A randomized controlled trial. (2021). Clinical Infectious Diseases. PubMed+1PMC+1

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