XELJANZ

Mfd. by :- Pfizer (Fulfilled By : Magicine Pharma)

Xeljanz

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name: Xeljanz  

Generic Name: Tofacitinib 

Manufacturer: Pfizer  

Dosage Form: Tablet  

Strength: 5mg, 10mg, 11mg, and 22mg.  

Composition: Tofacitinib  

Packaging: 60 tablets  

Indication: Rheumatology 

Storage: Store at room temperature  

Overview 

 Xeljanz (Tofacitinib) tablet is used in the treatment of Rheumatoid arthritis. It belongs to a class of medications known as immunomodulators. This medicine works by blocking the action of the enzyme, Janus kinase. It helps to decrease joint damage in rheumatoid arthritis. It is important to take Xeljanz tablets as prescribed by your doctor. It is advisable not to change your regular dosing schedule without taking suggestions from your doctor. The recommended dose of Xeljanz medicine is decided by a doctor according to your previous medical condition and response to the treatment. If you experience any signs and symptoms while receiving this medicine, inform your doctor immediately. 

Pharmacodynamics 

Tofacitinib targets inflammation present in rheumatoid arthritis by inhibiting the Janus kinases involved in the inflammatory response pathway. Treatment with Tofacitinib was associated with dose-dependent increases in B cell counts. Changes in circulating T-lymphocyte counts and T-lymphocyte subsets (CD3+, CD4+, and CD8+) were small and inconsistent. After treatment with Tofacitinib in patients with rheumatoid arthritis, rapid decreases in serum C-reactive protein (CRP) were observed and maintained throughout dosing.  

Usage 

This medicine is used to treat certain types of arthritis (Psoriatic Arthritis, Rheumatoid Arthritis, and polyarticular course juvenile idiopathic arthritis-pcJIA). Xeljanz tablets also help to block a certain enzyme in the body that affects the immune system. Take this tablet orally once a day with or without food. Do not take Xeljanz tablets in the wrong way as it may lead to some severe side effects. Regular monitoring of blood cell count, liver function, kidney function, and cholesterol levels is required during treatment with this medicine. Do not use Xeljanz (Tofacitinib) medicine if you are pregnant.  

Interactions  

Xeljanz tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor. 

Medicine Interactions  

  • Adalimumab  

  • Cisplatin  

  • Etoposide  

  • Fluconazole  

  • Lonafarnib  

  • Mitotane  

Disease Interactions  

  • Hepatitis B  

  • Viral reactivation 

  • Tuberculosis  

  • Infections  

  • Renal disease  

  • Hepatic Impairment  

Alcohol Interaction  

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.  

Contraindications  

  • Do not take this medicine if you are allergic to Tofacitinib. 

  • Xeljanz (Tofacitinib) medicine is not recommended in patients known to be hypersensitive. 

Side effects 

This medicine may cause some major and minor side effects. Discuss the risks and benefits of the Xeljanz tablets with the doctor before starting the treatment. 

Common side effects  

  • Bladder pain  

  • Irregular heartbeat  

  • Bloating  

  • Diarrhea  

  • Chills  

  • Runny or stuffy nose  

  • Nausea  

  • Unusual tiredness  

  • Headache  

  • Dizziness  

  • Fever  

  • Sore throat  

  • Weight loss  

  • Chest pain  

  • Ear congestion  

  • Back pain  

  • Inflammation of the throat and the nasal passage  

  • Upper respiratory tract infection 

  • Allergic reaction 

  • Unusual weakness  

  • Shortness of breath  

  • Muscle pain  

  • Pounding in the ears 

  • Swollen glands  

  • Decreased urination  

  • Fainting  

  • Rash  

  • Vomiting  

  • Sunken eyes  

  • Tingling of the hands or feet  

Note - immediately contact your health care provider if any side effects occur.  

Side effects 

This medicine may cause some major and minor side effects. Discuss the risks and benefits of the Xeljanz tablets with the doctor before starting the treatment. 

Common side effects  

  • Bladder pain  

  • Irregular heartbeat  

  • Bloating  

  • Diarrhea  

  • Chills  

  • Runny or stuffy nose  

  • Nausea  

  • Unusual tiredness  

  • Headache  

  • Dizziness  

  • Fever  

  • Sore throat  

  • Weight loss  

  • Chest pain  

  • Ear congestion  

  • Back pain  

  • Inflammation of the throat and the nasal passage  

  • Upper respiratory tract infection 

  • Allergic reaction 

  • Unusual weakness  

  • Shortness of breath  

  • Muscle pain  

  • Pounding in the ears 

  • Swollen glands  

  • Decreased urination  

  • Fainting  

  • Rash  

  • Vomiting  

  • Sunken eyes  

  • Tingling of the hands or feet  

Note - immediately contact your health care provider if any side effects occur.  

Dosage 

Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing schedule.  

Missed dose  

  • It is advisable not to miss a dose. If you miss a scheduled dose of Xeljanz tablets, contact your doctor immediately.  

Overdose  

  • In case of an overdose of Xeljanz tablets, the doctor will provide emergency medical treatment. 

Warnings  

Before starting treatment with Xeljanz medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.  

  •  Contraception  

  • Use suitable methods of contraception to prevent pregnancy while taking Xeljanz medicine.  

  • Children and adolescents  

  • Xeljanz Tablets are not recommended for use in children under 18 years of age.   

Warnings for Female  

  • Pregnancy 

  • Do not use Xeljanz medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy.  

  • Breastfeeding 

  • This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with Xeljanz (Tofacitinib). 

Precautions  

  • This medicine may affect the immune system and may increase the risk of developing infections.  

  • Xeljanz tablets may increase the levels of cholesterol and low-density lipoprotein cholesterol.  

  • Inform your doctor if you experience any side effects like - dizziness, nausea, abdominal pain, increased appetite, and vomiting. 

  • Close monitoring of liver and kidney function is required during treatment with this medicine.  

  • This medicine may increase the risk of non-melanoma skin cancer.  

Cautions 

  • Do not drive or operate heavy machinery. 

  • Do not crush or break the tablet.  

  • Not safe for pregnant women.  

  • Do not breastfeed while receiving this medication. 

Q1. What is Xeljanz (Tofacitinib)?  

Ans. This medicine is used in the treatment of Rheumatoid arthritis. It helps to block a certain enzyme in the body that affects the immune system.  

Q2.  In what strength is it available? 

Ans. This medicine is available in the strength of 5mg, 10mg, 11mg, and 22mg.  

Q3. What are the side effects?  

Ans. Some common side effects are - bladder pain, constipation, insomnia, sore throat, dizziness, fatigue, nausea, fever, etc.  

Q4. What happens if I miss a dose?  

Ans. If you miss a scheduled dose of Xeljanz tablets, contact your doctor immediately. 

Q5. How does Xeljanz work?  

Ans. This medicine works by blocking the action of the enzyme, Janus kinase. It helps to decrease joint damage in rheumatoid arthritis. 

Q6. Can I take this medicine during pregnancy?  

Ans. This medicine is not recommended during pregnancy. 

Q7. What should I avoid while receiving this medication?  

Ans. Follow your doctor’s advice about any restrictions on food and other activities. 

Q8.  How to take this medicine?  

Ans. It is important to take this medicine as prescribed by your doctor.  

Q9.  Can I drive after taking this medicine?  

Ans. This medicine may affect your vision and your ability to concentrate. 

Q10. Does this medicine affect kidney function?  

Ans.  Please consult your doctor before consuming this drug. 

Q11. What are the storage conditions?  

Ans. Store this medicine at room temperature. 

Q12. Can I take this medicine during breastfeeding?  

Ans. This medicine is not recommended in breastfeeding unless it is necessary. 

Q13. Can I consume alcohol while receiving this medicine?  

Ans. Please consult your doctor before consuming alcohol.  

  

Above Content has been reviewed by Professionals