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dr. reddys laboratories ltd
1 Injection
Denosumab
Keep in cold place
Delivering To:
Overview
Prolia 60mg Injection is used in the treatment of osteoporosis (bone loss) in patients who have a very high risk of bone fracture. Osteoporosis mostly happens in women after menopause, making it more likely to break easily. This medicine maintains bone density by slowing down bone loss and decreasing the risk of bone fractures. It belongs to the monoclonal antibodies class. Prolia 60mg Injection can also be used by males.
Bone disease
Osteoporosis/Bone disease
The human body reacts differently to Prolia 60mg Injection. Response or undesired symptoms vary from individual to individual. Usually, they disappear with time as the body adjusts to the medicine; these side effects don't need special medical attention. Whereas if the symptoms don't disappear with time or you have severe side effects, then consult your doctor immediately. Some of the common side effects of Prolia 60mg Injection are mentioned below: Rash, Sciatica, Musculoskeletal (bone, muscle, or joint ) pain. Infection in the upper respiratory tract, hair loss, headache, nerve pain, constipation, Eczema, urinary tract infection, Hypercholesterolemia (high cholesterol), Cystitis
The Prolia 60mg injection is injected in your upper thigh, stomach, or upper arm. Normally, you get it every 6 months. If cancer has spread to the bone, it is given every 4 weeks. If the cancer becomes a big bone tumor, you get it every 7 days. For more information, talk to your doctor. This injection should not be self-administered and should be given by a health care professional. Take a dose of Prolia 60mg injection every day at the same time and in the amount recommended by the doctor to get maximum benefit from the medicine. To make it more effective, take a balanced diet and take an adequate amount of vitamins and minerals while on treatment with Prolia 60mg injection
Prolia 60mg injection is a monoclonal antibody. It prevents bones from getting fractures or reduces the risk of bone loss by binding to a protein that weakens the bone. As a result, bones get strengthened and the risk of fractures is minimized.
Alcohol
unsafe
The interaction of alcohol with this drug is still unknown. It is advisable not to consume alcohol while taking Prolia 60mg injection. Consult your doctor for further information.
Pregnancy
consult your doctor
Prolia 60mg injection may be considered unsafe during pregnancy. Please consult your doctor in such a condition. According to some research data, taking Prolia 60mg injection during pregnancy has shown harmful effects on the developing baby.
Breast Feeding
consult your doctor
Prolia 60mg injection is probably not safe if you're breastfeeding. Kindly consult your doctor before taking Prolia 60mg injection while breastfeeding, as there are chances that it may pass to the developing baby through the breast milk of the mother.
Driving
danger
It is advisable not to drive or operate heavy machinery after taking Prolia 60mg injection, as you may feel dizzy.
Kidney
caution
Share your medical history with your healthcare expert in case of kidney disease before taking Prolia 60mg injection. Patients with renal impairment must be careful while taking Prolia 60mg injection. They may require adjustment in the dose.
Liver
caution
Inform your doctor before starting Prolia 60mg injection if you have liver disease to avoid any serious side effects. Patients with hepatic impairment must be careful while taking Prolia 60mg injection. They may require adjustment in the dose.
It is advisable not to miss any dose. In case you miss a dose of Prolia 60mg Injection consult your doctor soon.
Missing the dose will impact the overall health of the patients. So, it is always advisable to follow the prescription of the doctor strictly.
Prolia 60mg injection increases the bone density accordingly cancer cells.
The duration of treatment will depend on the stage of cancer and the overall health of patients.
Driving and operating heavy machinery is advisable because this injection makes you feel dizzy.
Pregnant women should consult a doctor before taking Prolia injection.
Yes, Prolia 60mg can cause hair loss, which is a common side effect of this medication. Consult your doctor if you are concerned about your hair loss.
Prolia 60mg injection can be stored in a refrigerator at 2 to 8 degrees Celsius in the sealed container without breaking it. Keeping the injection at a very warm or cold temperature can make it ineffective, and therefore, proper storage is required.
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Green W. (2024). Denosumab (Prolia) Injection: A New Approach to the Treatment of Women With Postmenopausal Osteoporosis. P T, 35(10):553–9.
Aubin JE, Bonnelye E. (2025). Osteoprotegerin and its ligand: A new paradigm for regulation of osteoclastogenesis and bone resorption. Osteoporos Int. 11:905–913.
Sattler A, Schoppet M, et al. Novel aspects on RANK ligand and osteoprotegerin in osteoporosis and vascular disease. Calcif Tissue Int. 74:103–106.
Nicolopoulos K, Moshi MR, Stringer D, Ma N, Jenal M, Vreugdenburg T. (2025). The clinical effectiveness of denosumab (Prolia®) in patients with hormone-sensitive cancer receiving endocrine therapy, compared to bisphosphonates, selective estrogen receptor modulators (SERM), and placebo: a systematic review and network meta-analysis. Arch Osteoporos. 10;18(1):18.
Jamshidi, A., Vojdanian, M., Soroush, M. et al. (2025). Efficacy and safety of the biosimilar denosumab candidate (Arylia) compared to the reference product (Prolia®) in postmenopausal osteoporosis: a phase III, randomized, two-armed, double-blind, parallel, active-controlled, and noninferiority clinical trial. Arthritis Res Ther 24, 161.
Francisco A. (2024). Sylvester, Effects of Digestive Diseases on Bone Metabolism. Pediatric Gastrointestinal and Liver Disease, (1116-1125.e8).
Savelli,G.,Oliviero,S.,Viceconti,M.,Mattina,M,L,A., (2025). In silico prediction of hip fractures: improved fall modeling and expanded validation across cohorts with diverse risk profiles, Journal of the Mechanical Behavior of Biomedical Materials, 172, (107182).
Singh, Inderjeet; Jose, Vinu; Patel, Ronak; Arora, Sumit INTP23. (2025). Study 051-14 Investigator Team. Denosumab biosimilar in postmenopausal osteoporotic women: A randomized, assessor-blind, active-controlled clinical trial. Indian Journal of Pharmacology 53(1):p 6-12.
dr. reddys laboratories ltd
Written By
Venika Choudhary
Medical Content Writer @ Magicine Pharma
I hold an M.Sc. in Microbiology and have a strong academic foundation in microbial sciences and applied biotechnology. I began my career with extensive hands-on research at CSIR laboratories, focusing on fungal enzyme production, studying fungal diversity in various ecosystems, and developing bio-pesticides as sustainable alternatives to chemical pesticides. This work deepened my understanding of fungal biology, bioactive compounds, and their pharmaceutical and agricultural applications. Transitioning from research, I now work as a medical content writer, where I combine my scientific expertise with a passion for clear and reliable healthcare communication. I apply my research background to create patient-friendly, compliant content for pharmaceutical companies and healthcare platforms, ensuring science is both trustworthy and accessible. Specializing in clear, accurate, and engaging content, I help patients make informed decisions and support pharmaceutical companies in delivering trusted information. Whether writing product descriptions, crafting disease awareness articles, or composing drug information leaflets, I consistently meet regulatory standards and address audience needs, making my content an asset for healthcare brands.