Marketed By
astellas
Pack of
10 Capsule in Strip
Salt Composition
Tacrolimus
Storage
Keep in cold Place
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1
Advagraf 1mg Capsule
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Overview
Advagraf 1mg, a capsule, is administered to prevent the body from rejecting a new organ (heart, liver, or kidney) after a transplant. This type of medication, which is classified as an immunosuppressant, works by impairing the immune system to prevent it from attacking the body's new organs.
Indication
Organ Transplant
Reference
Crespo, M., Mir, M., Marin, M., Hurtado, S., Estadella, C., Guri, X. & Lloveras, J. (2022). De novo kidney transplant recipients need higher doses of Advagraf compared with Prograf to get therapeutic levels. In Transplantation proceedings (Vol. 41, No. 6, pp. 2115-2117). Elsevier.
Dabare, D., Macanovic, J., Graetz, K., & Gibbs, P. (2023). Advagraf® and Myfortic® in combination are associated with fewer gastrointestinal symptoms in kidney transplant recipients. The Annals of The Royal College of Surgeons of England, 95(5), e11-e11.
Noble, J., Jouve, T., Rostaing, L., & Malvezzi, P. (2025). Advagraf® with or without an induction therapy for de novo kidney-transplant recipients. Expert Review of Clinical Immunology, 14(6), 461-467.
Spagnoletti, G., Gargiulo, A., Salerno, M. P., Favi, E., Pedroso, J. A., Calia, R. & Citterio, F. (2024). Conversion from Prograf to Advagraf in stable kidney transplant recipients: better renal function after 3-year follow-up. In Transplantation Proceedings (Vol. 46, No. 7, pp. 2224-2227). Elsevier.
Vasquez, E. M., Tanzi, M., Benedetti, E., & Pollak, R. (2023). Medication noncompliance after kidney transplantation. American journal of health-system pharmacy, 60(3), 266-269.
Uses
Prevention of organ rejection in transplant patients
Benefits
Side Effects
Undesired symptoms or responses vary from person to person as the human body reacts differently to the Advagraf 1 mg capsule, but they typically resolve naturally within a few days as the body adjusts to the medicine, requiring no medical attention. In case these symptoms don't go away and you face severe side effects, then immediately consult your doctor or medical team. Some of the common side effects of the Advagraf 1 mg Capsule are:
Infection
Headache,
Fever
Loss of appetite
High blood pressure
lack of sleep.
Indigestion
Nausea
Kidney damage
diarrhea, or constipation
How To Use
Anyone with a history of renal, hepatic, cardiovascular, hypoglycemic, or fluid retention should not take Advagraf 1mg Capsule. As directed by your physician, you can take it on an empty or full stomach. Advagraf 1 mg Capsule may interfere with other medications, so it's advised to let your doctor know before taking any other medications. Chewing, crushing, or breaking the medication is not advised.
How It Works
The body's immune system is suppressed by Advagraf 1mg capsules. It is an immunosuppressant that helps in the body's acceptance of the newly transplanted organ (kidney, liver, and heart). Advagraf 1mg Capsule contains tacrolimus, which binds to FKBP-12 and suppresses the synthesis of IL-2 and calcineurin, hence suppressing the immunological response.
Safety Advice
Alcohol
consult your doctor
Excessive alcohol consumption can decrease the immunity of the individual and weaken the liver function. However, moderate levels of alcohol do not interfere with the working of the Advagraf 1 mg Capsule, as per the research.
Pregnancy
consult your doctor
The Advagraf 1 mg Capsule should be injected after consulting the doctor; during pregnancy, it is not suggested to take it routinely. Advagraf 1 mg Capsule can be injected in case of severe, life-threatening conditions. However, it may harm the unborn.
Breast Feeding
consult your doctor
The Advagraf 1 mg Capsule is considered unsafe to be taken while breastfeeding, as there is a chance that it may pass to the developing baby through the breast milk of the mother. It is generally considered unsafe, and there is no clear evidence found in the clinical data on how it harms the baby.
Driving
unsafe
Driving after taking the Advagraf 1 mg Capsule may affect or interfere with driving ability or distract while operating machinery. Fever or dizziness, neurological effects can be seen after taking the capsule. Avoid driving until you feel better.
Kidney
safe if prescribed
The Advagraf 1 mg Capsule is considered unsafe for people with kidney problems. It can damage the kidneys. Tacrolimus, present in the capsule, is nephrotoxic.
Liver
safe if prescribed
The Advagraf 1 mg Capsule is generally considered unsafe for people with mild to moderate liver disease. Although regular monitoring of the enzyme is required. The dose should be adjusted; take it with caution.
Missed Doses
Quick Tips
FAQs
Advagraf 1 mg Capsule is used to suppress the body's immune system. It is an immunosuppressant that helps the body to accept the new organ after transplant (heart, liver, and kidney). Advagraf 1 mg Capsule consists of tacrolimus that binds to FKBP-12, and it inhibits calcineurin and IL-2 production, and as a result, the immune response is suppressed.
Inform the doctor if you are allergic to the ingredient present in the Advagraf 1 mg capsule, in case of high sugar level, pregnancy or breastfeeding, or a weakened immune system. Patient with medical history or medication.
As the capsule suppresses the immune system, the risk of infection increases. Advagraf 1 mg Capsule can increase the risk of getting cancer, such as lymph gland cancer (lymphoma) and skin cancer. It can lower the body's ability to fight infections.
Yes, Advagraf 1 mg Capsule comes under the class macrolides, which is an antibiotic group of medicines. It is used after organ transplantation and helps prevent organ rejection after a heart, kidney, or liver transplant.
It is advised not to take alcohol while taking the Advagraf 1 mg Capsule, because consuming alcohol can cause serious side effects and can damage your liver badly. Consult your doctor if you have concerns or queries.
As soon as you remember, take the missed dose unless it's time for your next dose. You should never take a double dose to make up for a missed one.
Common side effects of the Advagraf 1 mg tablet are constipation, muscle pain, swelling, nausea, diarrhea, infection, loss of appetite, hair loss, vomiting, and weakness.
The doctor decides how long the treatment with the Advagraf 1 mg tablet will continue, depending on the stage and health of the patient.
During pregnancy, it is not safe to take Advagraf 1 mg, as it can cause harm to the unborn baby. Also, during breastfeeding, this medicine must not be used. Please make sure to consult your healthcare provider regarding the same.
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