Brand name - Imbruvica
Generic name - Ibrutinib
Salt composition - Ibrutinib
Manufacturer - Janssen Biotech
Dosage form - Capsule
Packaging - Bottle
Indication - Leukemia
Strength - 140mg
Storage - Store at room temperature 20°C to 25°C.
Prescription required - Yes
Uses of Imbruvica
Imbruvica 140mg Capsule (Ibrutinib) is used in the treatment of:
Mantle cell lymphoma (MCL)
Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL)
Waldenström’s macroglobulinemia (WM)
Marginal zone lymphoma (MZL)
Chronic graft versus host disease (GVHD)
The active ingredient of the Imbruvica 140 mg capsule is Ibrutinib. It is a small-molecule inhibitor of BTK.
Ibrutinib is a small-molecule inhibitor of BTK. It forms a covalent bond with a cysteine residue in the BTK active site and then leads to inhibition of BTK enzymatic activity. BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways. Nonclinical studies suggest that ibrutinib works to inhibit malignant B-cell proliferation and survival in vivo along with cell migration and substrate adhesion in vitro.
Side effects of Imbruvica 140mg Capsule
High blood pressure
Change in speech
Chest pain or discomfort
Shortness of breath
Low blood cell count
Fever and chills
Take Imbruvica capsule in the same strength as prescribed by your healthcare provider. Do not cut, break or chew the capsule. Swallow it as a whole. Do not stop taking this capsule as per your wish.
In case you miss a dose, make sure to take it on the same day itself. However, if it is already the time for your next dose, tell your healthcare provider about the same to get needed guidance. Do not increase the dose strength to compensate for the missed dose.
It is advised to seek professional medical attention in case of overdose.
Warning and precautions
Make sure to tell your healthcare provider beforehand if you:
Have any infection
Have kidney problems
Have liver problems
Have heart problems
Do not crush, chew, break or cut the capsule. Swallow it as a whole, exactly in the same dose as prescribed by your healthcare provider. Do not stop taking this capsule as per your wish.
Do not drive or operate heavy machines (after taking this capsule), if you feel unwell.
Do not administer this capsule without a proper prescription by your healthcare provider.
Q1- What is the Imbruvica capsule used for?
A- Imbruvica (Ibrutinib) capsule is used to treat mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), waldenström’s macroglobulinemia (WM), marginal zone lymphoma (MZL), and graft versus host disease (GVHD).
Q2- What is the available strength of this capsule?
A- It is available in the strength of 140 mg.
Q3- What are the common side effects of the Imbruvica 140mg capsule?
A- The side effects are diarrhea, skin rash, itching, pneumonia, fever, chills, high blood pressure, etc. Make sure to tell your doctor regarding the side effects you experience (these or any other).
Q4- How should I store Imbruvica 140mg Capsule?
A- Store at room temperature 20°C to 25°C.
Q5- Can I consume Imbruvica 140mg Capsule during pregnancy?
A- Imbruvica capsule may cause harm to the developing baby. Make sure to consult your healthcare provider.
Q6- Can I consume Imbruvica 140mg Capsule during breastfeeding?
A- Imbruvica capsule is safe during breastfeeding, only if the healthcare provider prescribes it. Make sure to discuss the potential risks.
Q7- Is alcohol consumption safe with this medication?
A- Before consuming alcohol with this capsule, make sure to ask your healthcare provider regarding the same.
Q8- What should I avoid while consuming Imbruvica 140mg Capsule?
A- Avoid the consumption of grapefruit juice.
Q9- Is Imbruvica 140mg Capsule safe for use in children?
A- It is not known whether the Imbruvica capsule is safe for use in children or not.
Q10- Is it a habit-forming medication?
A- It is not a habit-forming medication.
Ibrutinib: Drugs information and usage are available at: - https://go.drugbank.com/drugs/DB09053, https://www.cancer.gov/about-cancer/treatment/drugs/ibrutinib, and https://www.drugs.com/ibrutinib.html
Ibrutinib: Mechanism, side effects, and dosage are available at: - https://medlineplus.gov/druginfo/meds/a614007.html, https://www.webmd.com/drugs/2/drug-165428-1576/ibrutinib-oral/ibrutinib-oral/details, and https://www.cancerresearchuk.org/about-cancer/treatment/drugs/ibrutinib.