LENVIMA

Mfd. by :- Eisai (Fulfilled By : Magicine Pharma)

Lenvima

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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PACKAGE

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Brand Name:- Lenvima

Generic Name:- Lenvatinib

Manufacturer:- Eisai

Dosage Form:- Capsule 

Strength:- 10mg 

Composition:- Lenvatinib

Packaging:- 10 capsule (10/strip) 

Indication:- Kidney, Thyroid, and Liver cancer 

Storage:- Store at room temperature.

Overview

Lenvima (Lenvatinib) is a medicine that is used to treat certain kinds of cancer (Thyroid cancer, Kidney cancer, and Liver cancer). This medicine belongs to a group of cancer-fighting medications known as antineoplastic. Take this medicine with or without food. Your doctor will decide the exact dosage. Do not take this medicine in the wrong way as it may lead to some severe side effects. If you experience any symptoms while receiving this medicine, inform your doctor immediately. It is advisable not to change or stop the dose without taking suggestions from your doctor. This medicine is not recommended for pregnant women.

Pharmacodynamics of Lenvima (Lenvatinib)

Lenvatinib is a receptor tyrosine kinase receptor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1, VEGFR2, VEGFR3. Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular functions, including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, and 4; the platelet-derived growth factor receptor alpha (PDGFRα), KIT, and RET. After the oral administration, the effect of this medicine can be observed in 1 to 4 hours. 

Side effects of Lenvima (Lenvatinib)

This medicine may cause some serious and unwanted side effects. It requires immediate medical attention otherwise it can also lead to higher risk. Discuss the risks and benefits of this medication with a medical advisor before starting the treatment. 

Common side effects 

  • Bladder pain 

  • Constipation 

  • Dizziness 

  • Diarrhea 

  • Bleeding 

  • Sore throat 

  • Vomiting 

  • Coughing up blood 

  • Skin rash 

  • Joint pain 

  • Nausea 

  • Tiredness 

  • Loss of appetite 

  • Indigestion 

  • Pale skin

  • High blood pressure 

  • Headache 

  • Fatigue 

  • Irregular heartbeat 

  • Bloating 

  • Chest pain 

  • Hair loss 

  • Rapid weight gain 

  • Pounding in the ears

  • Change or loss of taste 

  • Painful or difficult urination 

  • Unusual bruising 

  • Shortness of breath 

  • Slow wound healing 

  • Change in vision 

  • Numbness 

  • Allergic reaction 

  • Low calcium levels 

  • Anxiety 

Note- Please contact your doctor, if any side effect occurs.

Dosage

Take this medicine as prescribed by your doctor. Do not chew or open the capsule. Take this medicine with or without food. 

Missed dose 

  •  It is advisable not to miss a dose. If you miss a scheduled dose of Lenvima capsule, contact your doctor immediately. 

Overdose 

  • In case of an overdose, the doctor will provide emergency medical treatment. 

Usage of Lenvima (Lenvatinib) 

This medicine belongs to a class of drugs known as tyrosine kinase inhibitors. It is an anti-cancer medication. This medication works by blocking the nutrient supply, which helps to stop the growth of cancer cells. Take this medicine orally once a day. Do not chew or open the capsule. The dose is decided by a medical advisor according to response to the treatment and your previous medical condition. Try not to miss your dosing schedule. Protect this medicine from heat and light. 

Interactions

Interactions may change how your medication works and increase the risk for side effects. Don’t forget to disclose your previous medical history with the doctor. 

Medicine interaction 

  • Moxifloxacin 

  • Halofantrine 

  • Methadone 

  • Amiodarone 

  • Nilotinib 

  • Vandetanib 

Disease interaction 

  • Hypertension 

  • Diarrhea 

  • Hepatic impairment 

  • Hypothyroidism 

  • Cardiac dysfunction 

  • Bleeding

  • Renal impairment 

Alcohol interaction  

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol. 

Contraindication

  • Lenvima capsules are not recommended for use in patients with known allergy to Lenvatinib.  

  • This medicine is contracted in patients known to be hypersensitive.

Warnings

Before starting treatment with Lenvima, please inform your doctor about your previous medical history. If you experience any symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk. 

  •  Contraception 

    • Use effective methods of contraception to prevent pregnancy while taking this medicine. 

  • Children and adolescents 

    • This medicine is not advisable for use in children and adolescents. 

Warnings for female 

  • Pregnancy 

    • Lenvima capsules shouldn’t be used by pregnant women. Lenvatinib may cause harm to the baby. It is recommended that this medicine should be avoided during pregnancy. 

  • Breastfeeding 

    • This medicine is not recommended in breastfeeding unless it is necessary. Please consult your medical advisor before starting treatment with this medication.

Precautions

  • Close monitoring of kidney function and liver function is required during the treatment with this medicine. 

  • This medication can affect the way the body uses thyroid hormones.

  • This medicine may increase the risk of bleeding.

  • Close monitoring of blood calcium levels and dose adjustment is required in some patients. 

  • This medicine should be used with caution in patients suffering from heart disease. 

  • This medicine may increase the chance of blood clots. 

  • This medication may delay wound healing. 

Cautions

  • Do not crush or chew the capsule. 

  • Do not drive or operate heavy machinery. 

  • Not safe for pregnant women. 

  • Do not breastfeed while receiving this medication. 

Q1. What is Lenvima (Lenvatinib)? 

Ans. Lenvima (Lenvatinib) is a medicine that is used to treat certain kinds of cancer, Thyroid cancer, Kidney cancer, and Liver cancer.

Q2. How does Lenvima (Lenvatinib) work? 

Ans. This medicine belongs to a class of drugs known as tyrosine kinase inhibitors. It is an anti-cancer medication. This medication works by blocking the nutrient supply, which helps to stop the growth of cancer cells.

Q3. What are the side effects? 

Ans. Some side effects are:- Constipation, bladder pain, diarrhea, bleeding, skin rash, high blood pressure, vomiting, pale skin, muscle pain, dizziness, etc. 

Q4. In what strength is it available? 

Ans. It is available in the strength of 4mg and 10mg. 

Q5. What should I avoid while receiving this medicine? 

Ans. Follow your doctor’s instructions about any restrictions on food and other activities. 

Q6. What are the self-care tips? 

Ans. Keep yourself hydrated and maintain good nutrition. 

Q7.  What happens if I miss a dose? 

Ans. If you miss a scheduled dose of this medicine, contact your doctor immediately. 

Q8. How to take this medicine? 

Ans.  Take this medicine with or without food orally once a day.

Q9. Can I take this medicine during pregnancy?

Ans. This medicine is not recommended for pregnant women.

Q10. Can I consume alcohol while taking this medicine? 

Ans. It is not known whether it is safe or not. Please consult your doctor before consuming alcohol. 

Q11. Does this medicine affect liver function? 

Ans. Please contact your doctor before consuming this drug. 

Q12. Can I take this medicine during breastfeeding? 

Ans. This medicine is not recommended in breastfeeding unless it is necessary.

Q13. Can I drive after taking this medicine? 

Ans. This medicine may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur. 

Q14. What are the storage conditions? 

Ans. Store this medicine at room temperature. Do not crush the capsules.

Above Content has been reviewed by Professionals