Mfd. by :- Aprazer Healthcare Pvt Ltd (Fulfilled By : Magicine Pharma)
Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.
Brand name - Ribasure
Generic name - Ribavirin
Manufacturer - Aprazer Healthcare Pvt
Salt composition - Ribavirin 200mg
Storage - Store at room temperature (10-30°C)
Dosage form - Oral
Strength - 200mg
Packaging size - 140 capsules
Packaging type - Bottle
Indication - Used in the treatment of chronic Hepatitis C virus.
Intended patient - Unisex
Active ingredient - Ribavirin
Ribasure Capsule is an antiviral medicine. It is used in the treatment of chronic Hepatitis C virus (HCV) infection. Ribasure prevents the multiplication of viruses in human cells, thereby clearing the infection.
Ribasure capsule is used for people who have not been treated with an interferon before.
Pharmacotherapeutic group: Nucleosides and nucleotides (excl. reverse transcriptase inhibitors).
Mechanism of Action: Ribavirin is a synthetic nucleoside analog that shows in vitro activity against some RNA and DNA viruses. The mechanism is unknown by which ribavirin exerts its effects against HCV.
HCV RNA levels decline in a biphasic manner in responding patients with hepatitis C who have received treatment with 180 µg peginterferon alfa-2a. The first phase of decline occurs 24 to 36 hours after the first dose of peginterferon alfa-2a and is followed by the second phase of decline which continues over the next 4 to 16 weeks in patients who gain a sustained response. Ribavirin showed no significant effect on the initial viral kinetics over the first 4 to 6 weeks in patients treated with the combination of Ribavirin and pegylated interferon alfa-2a or interferon alfa.
Oral formulations of ribavirin monotherapy have been investigated as therapy for chronic hepatitis C in several clinical trials. Results of such investigations stated that ribavirin monotherapy showed no effect on clearing hepatitis virus (HCV-RNA) or improving hepatic histology after 6 to 12 months of therapy and 6 months of follow-up.
Study results in treatment-naive patients: Study (1121 patients treated) compared the efficacy of 48 weeks of treatment with peginterferon alfa-2a (180 µg once weekly) and Ribavirin (1000/1200 mg daily) with either peginterferon alfa-2a monotherapy or combination therapy with interferon-alfa-2b and ribavirin. The combination of peginterferon alfa-2a and Ribavirin was notably more efficacious than either the combination of interferon alfa-2b and ribavirin or peginterferon alfa-2a monotherapy.
The therapeutic efficacy of interferon alfa-2a alone and in combination with oral ribavirin was compared in clinical trials in naive and deteriorated patients who had virologically, biochemically and histologically documented chronic hepatitis C. Six months after end of treatment sustained biochemical and virological response as well as histological improvement were viewed.
A significant 10-fold increase (from 4% to 43%; p <0.01) in sustained virological and biochemical response was noted in relapsed patients (M23136; N=99). The favourable profile of the combination therapy was also reflected. In the combination and interferon monotherapy arms, respectively, the sustained response rates in patients with HCV genotype-1 were 28% versus 0% and with genotype non-1 were 58% versus 8%. In addition, the histological improvement favoured the combination therapy. Supportive favourable results from a published study in naive patients (N=40) were reported using interferon alfa-2a (3 MIU 3 times per week) with ribavirin.
Ribasure 200mg ( Ribavirin) is used in combination with other antiviral medicines in the treatment of chronic Hepatitis C. Chronic hepatitis C infection can cause liver problems like scarring (cirrhosis), or liver cancer. Ribasure 200mg capsule ( Ribavirin) works to reduce the amount of hepatitis C virus in the body.
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Rinhib 200mg capsule
Ribavin 200mg capsule
Rebetol 20g capsule
Ribasure capsule should not be used if you have:
Depression and anxiety
Other liver problems
Kidney problems
Cardiac disease
Cough and vomit
Upset stomach or constipation
Diarrhea
Heartburn
Loss of appetite
Weight loss
Change in ability to taste food
Dry mouth
Difficulty in concentrating
difficulty falling asleep
Memory loss
Rashes
Dry or itchy skin
Sweating
Irregular or painful menstruation
Muscle pain
Hair loss
Allergy
Swelling on the face, throat, feet, ankles, legs or any other body part
Hoarseness
Difficulty in swallowing or breathing
Stomach ache
Bloody diarrhea
Blood in stools
Black stools
Stomach bloating
Confusion and tension
Dark-colored urine
Yellowing of the skin or eyes
Unusual bleeding
Vision changes
Anxiety and depression
Thinking about hurting or killing yourself
Changes in mood
Worry
Irritability
Intolerance to extreme temperatures
Take this medicine exactly as your healthcare provider prescribes. Do not chew, crush or break the capsule.
1. If you experience an allergic reaction, call your healthcare provider immediately.
2. Please do not change your dose, unless instructed by your healthcare provider.
3. Before beginning this medication, kindly ensure that your healthcare provider is aware of the following:
If you are pregnant.
If you are breastfeeding.
If you have any allergies.
If you have any other disorders or medical conditions.
If you are using any supplements.
Ques-1 What is Ribasure?
Ans-1 Ribasure is an antiviral medicine used in the treatment of chronic hepatitis C.
Ques-2 How should I take Ribasure?
Ans-2 Take Ribasure 200mg exactly as your healthcare provider tells you.
Ques-3 What are the possible side effects of Ribasure?
Ans-3 The common side effects are cough, vomit, constipation, loss of appetite, weight loss, dry mouth, difficulty concentrating, rash and dry skin. The serious side effects are hives, swelling of the face, difficulty swallowing or breathing, depression, mood changes, dark-colored urine, yellowing of the skin, excessive worry and bleeding. Please contact your healthcare provider if you experience these/any other symptoms.
Ques-4 In what strength is it available?
Ans-4 It is available in the strength of 200mg.
Ques-5 What happens if I miss a dose?
Ans-5 Please consult your healthcare provider.
Ques-6 What should I avoid while consuming this medicine?
Ans-6 Avoid consuming alcohol. Alcohol may worsen liver problems.
Ques-7 What are self care tips?
Ans-7 Take plenty of fluids.
Ques-8 Can I take this medicine during pregnancy?
Ans-8 Please consult your healthcare provider.
Ques-9 Can I drive after taking this medicine?
Ans-9 Ribavirin may make you drowsy or confused. Do not drive or operate machinery.
Ques-10 What are the storage conditions?
Ans-10 Store at room temperature (10-30°C).
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