Brand Name :- Cyramza
Generic Name :- Ramucirumab
Manufacturer :- Lilly
Dosage Form :- Injection
Strength :- 500mg/50ml
Composition :- Ramucirumab
Packaging :- 1vial
Indication :- Stomach cancer, non-small cell lung cancer, colorectal cancer.
Storage conditions :- Protect from light. Do not shake or freeze the vial.
Cyramza (ramucirumab) is a medicine used to treat stomach cancer (that got worse during or after a certain another type of chemotherapy), colorectal cancer, and non-small cell lung cancer that has spread to other parts of the body. This medication interferes with the growth of cancer cells in the body. This medication comes in the form of an injection and it is given as an infusion every 2 to 3 weeks by your doctor or nurse. This medicine works by stopping the formation of blood vessels that brings oxygen and nutrients to tumors. This may slow the growth and spread of tumors.
Pharmacodynamics of Cyramza (ramucirumab)
Ramucirumab is a VEGFR2 antagonist that specifically binds VEGFR2 and blocks binding of VEGFR ligands, VEGF-A, VEGF-C and VEGF-D. A dose range of 6-12mg administered every two or three weeks. Ramucirumab systematic exposure increased dose proportionally at doses of 8mg and above and steady-state concentrations were achieved at approximately 12 weeks.
Side effects of Cyramza (ramucirumab)
This medicine may cause some unwanted side effects. If they occur it may require medical attention.
Common side effects
Serious side effects
Note - Always inform your doctor, if you experience any unusual symptoms
This medication is given by slow injection into a vein by doctor or nurse. The dosage is based on your medical condition, weight, age, and response to the treatment.
Usage of Cyramza (ramucirumab)
This medication is used to treat stomach cancer, non-small cell lung cancer and it is also approved to treat colorectal cancer. It is also approved for use in combination with docetaxel to treat patients with metastatic non-small cell lung cancer. This medication is given by slow injection into a vein by a doctor or nurse. The dosage is based on your medical condition, weight, age, and response to the treatment.
General warnings and precautions
Cyramza increase the risk of hemorrhage.
This medication increases the risk of gastrointestinal perforations.
Impaired wound healing can occur in patients who receive drugs that inhibit VEGF and VEGFR pathways.
Infusion related observed reactions that include - back pains, chest pain, chills etc.
Before using this medication tell your doctor about your medical history of kidney disease, high blood pressure, liver disease.
Increases risk of bleeding
Close monitoring is necessary
Not safe for pregnant womens
Q1. What is Cyramza (ramucirumab)?
Ans. Cyramza (ramucirumab) is a medicine used to treat stomach cancer (that got worse during or after a certain other type of chemotherapy), colorectal cancer and non-small cell lung cancer that has spread to other parts of the body.
Q2. How does it work?
Ans. Ramucirumab is a monoclonal antibody that works by targeting and binding with the vascular endothelial growth factor receptor-2 (VEGFR-2) and blocks the activation of VEGF.
Q3. What are the side effects?
Ans. Some common side effects are - vomiting, constipation, fainting, fever, chills, swelling, chest pain, joint pain, weakness, shivering, nose bleeds, itching.
Q4. How is Cyramza given?
Ans. This medication is given in the form of injection into your vein by your doctor or nurse. Follow your doctor dosing information carefully.
Q5. In what strength is it available?
Ans. It is available in the strength of 500mg/50ml.
Q6. What should I avoid while taking this medicine?
Ans. Follow your doctor’s instructions about any restrictions on food or activity.
Q7. What if I miss a dose?
Ans. Immediately contact your doctor, if you miss a dose of Cyramza.
Q8. What are the self-care tips?
Ans. Keep yourself hydrated and maintain good nutrition. Close monitoring is necessary.
Q9. When should patients notify their physician?
Ans. This medication can cause severe bleeding, abdominal pain, diarrhea. If any of these symptoms occurs immediately contact your doctor.
Q10. Is it safe to take this medicine during pregnancy?
Ans. Cyramza (ramucirumab) injection is unsafe to use during pregnancy. Please consult your doctor.
Q11. Can I consume alcohol while taking this medicine?
Ans.It is advisable to consult your doctor, before consuming alcohol.
Q12. Is it safe to take this medicine during breastfeeding?
Ans. This medicine is unsafe to take during breastfeeding. Please consult your doctor regarding this.
Q13. Is it safe to drive after taking this medicine?
Ans. Cyramza (ramucirumab) injection does not usually affect your ability to drive.
Q14. What are the storage conditions?
Ans. Protect this medicine from light and do not shake or freeze the vial.
Before taking Cyramza (ramucirumab) injection, talk with your doctor and tell them about all prescriptions and other drugs you take.