Marketed By
Astra Zeneca
Pack of
1 vial
Salt Composition
Durvalumab
Storage
Keep in cold place
Delivering To: —
All Substitutes
Overview
- Imfinzi (durvalumab), 500 mg, belongs to the group of immunotherapy medications.
- The mechanism of action includes inhibition of the PD-L1 protein that increases the efficacy of the immune response toward the tumor.
- It is primarily prescribed for several advanced cancers.
- In lung cancer, it is used for adults with unresectable Stage III non-small cell lung cancer (NSCLC) that has not progressed after chemoradiation, and in combination with Tremelimumab and chemotherapy for metastatic NSCLC. For extensive-stage small cell lung cancer (SCLC), it is given alongside etoposide and carboplatin or cisplatin.
- In biliary tract cancers, including bile duct and gallbladder cancer, it is combined with gemcitabine and cisplatin. It also plays a role in treating advanced or unresectable hepatocellular carcinoma (liver cancer), often with bevacizumab, and is used with carboplatin and paclitaxel for mismatch repair deficient (dMMR) advanced or recurrent endometrial cancer.
- Moreover, Imfinzi may be used to treat selected instances of invasive bladder cancer.
- It is injected intravenously, and treatment is carried out until the disease progresses or side effects occur.
- While it is beneficial, it has risks that are associated with immune reactions on organs such as the lungs, liver, gastrointestinal system, kidneys, and endocrine glands.
Indication
- Non-Small Cell Lung Cancer (NSCLC)
- Small Cell Lung Cancer (SCLC)
- Biliary Tract Cancer (BTC)
- Hepatocellular Carcinoma (HCC)
- Endometrial Cancer
Side Effects
Like most anticancer drugs, Imfinzi 500mg Injection may cause some adverse effects on the body during the treatment. These can vary from mild to severe depending on the dose and the patient’s health condition. Inform your doctor immediately if you experience any persistent or unusual side effects. Side effects include:
- Cough
- Upper respiratory tract infections
- Fatigue / tiredness
- Rash
- Hair loss
- Diarrhea
- Itching
- Abdominal pain
- Musculoskeletal pain (bones, muscles, joints)
- Muscle pain (myalgia)
- Hoarse voice (dysphonia)
- Night sweats
- Shortness of breath / breathlessness
- Pneumonitis (lung inflammation)
- Pneumonia (serious lung infection)
- General infections (chills, fever)
- Fungal infection in the mouth
- Tooth and mouth soft tissue infections
- Flu-like illness
- Abnormal liver tests (AST/ALT increased)
- Abnormal kidney function tests (blood creatinine increased)
- Painful urination
- Swelling of the legs (peripheral edema)
- Overactive thyroid (fast heart rate, weight loss)
- Infusion reactions (fever, flushing)
How To Use
- Imfinzi 500mg Injection should be given intravenously by a doctor or experienced nurse under strict medical supervision.
- It is not intended for self-administration.
- The doctor will determine the appropriate dosage and duration of treatment based on the type and stage of cancer, as well as the patient's health condition.
- It can be used alone or in combination with other medicines during the treatment.
Safety Advice
Alcohol
CONSULT YOUR DOCTOR
Pregnancy
UNSAFE
Breast Feeding
UNSAFE
Driving
DANGER
Kidney
CONSULT YOUR DOCTOR
Liver
CONSULT YOUR DOCTOR
Missed Doses
- In case you missed a dose of Durvalumab injection, immediately contact your doctor.
FAQs
This medicine is used to treat various cancers, including non-small cell lung cancer, liver cancer, endometrial cancer, biliary tract cancer and small cell lung cancer.
Imfinzi 500mg Injection is an immunotherapy that works by helping your immune system to fight cancer. This medicine blocks the action of PD-L1, exerts its anticancer effects by increasing T-cell activation, and allows them to destroy cancer cells.
This medicine is administered by a doctor or a nurse. It is injected slowly into your vein. This infusion usually lasts 60 minutes, and this medicine is given once every 2 to 4 weeks.
Side effects include cough, upper respiratory tract infections, fatigue, rash, hair loss, diarrhea, itching, abdominal pain, musculoskeletal or muscle pain, hoarse voice, night sweats, shortness of breath, pneumonitis, pneumonia, general infections with fever or chills, fungal infections in the mouth, tooth and mouth tissue infections, flu-like illness, abnormal liver and kidney test results, painful urination, swelling of the legs, overactive thyroid, and infusion reactions such as fever or flushing.
This medicine may cause dizziness, which affects your ability to drive and concentrate.
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References
- Dewi, I. G. A. G. S., Putri, L. A. L. N., Silalahi, L. D., Widha, I. G. A., Dewi, P., Hapsari, M. D., ... & Warditiani, N. K. (2025). Systematic Literature Review on Sterile Injectable Dates of Use, Stability and Implications for Use. Svāsthya: Trends in General Medicine and Public Health, 2(1), e66-e66 - https://journal.megsci-ind.org/index.php/Svasthya/article/view/66
- Paik, P. K., Luo, J., Ai, N., Kim, R., Ahn, L., Biswas, A., ... & Kris, M. G. (2022). Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas. Nature Communications, 13(1), 6095 - https://www.nature.com/articles/s41467-022-33719-6
- Al-Salama, Z. T. (2021). Durvalumab: a review in extensive-stage SCLC. Targeted Oncology, 16(6), 857-864 - https://pubmed.ncbi.nlm.nih.gov/34731446/
- Almasi, J., Thiesen, J., & Krämer, I. (2023). Physicochemical stability of durvalumab (Imfinzi®) concentrate for solution in original vials after first opening. Pharmaceutical Technology in Hospital Pharmacy, 8(1), 20230008 - https://www.degruyterbrill.com/document/doi/10.1515/pthp-2023-0008/html
- Day-Storms, J. (2023). IMJUDO (Tremelimumab-actl) in Combination With IMFINZI (Durvalumab) Receives FDA Approval for HCC and NSCLC - https://www.ahdbonline.com/issues/2023/september-2023-vol-16-payers-guide/imjudo-tremelimumab-actl-in-combination-with-imfinzi-durvalumab-receives-fda-approval-for-hcc-and-nsclc
- Rashid, M. A. (2023). New Indications & Dosage Forms for Existing Drugs Vol. 26 (1). Bangladesh Pharmaceutical Journal, 26(1), 114-118 - https://www.banglajol.info/index.php/BPJ/article/view/71454/47793
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MARKETER DETAILS
Astra Zeneca
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