IMFINZI

Mfd. by :- Astra zaneca (Fulfilled By : Magicine Pharma)

Imfinzi

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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PACKAGE

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Brand Name:- Imfinzi 

Generic Name:- Durvalumab

Manufacturer:- Astra zaneca 

Dosage Form:- Injection 

Strength:- 500mg/10ml

Composition:- Durvalumab

Packaging:- 1vial

Indication:- Non-small cell lung cancer

Storage:- Store in a refrigerator. Do not freeze. 

Overview 

Imfinzi (Durvalumab) injection is used to treat non-small cell lung cancer. This medication works by blocking the activity of programmed death-ligand 1 (PD-L1) proteins and helps the immune system to attack cancer cells. This medicine is administered through intravenous injection by your doctor or nurse. This medicine is given when cancer has spread in other areas of your body or cannot be removed by surgery. Take this injection as prescribed by your medical advisor. Do not stop the use of dosage without taking permission from your doctor. 

Pharmacodynamics of Imfinzi (Durvalumab)

Durvalumab is an anti-cancer that works to promote the anti-tumor responses mediated by immune cells. This medicine blocks the action of PD-L1, exerts its anticancer effects by increasing T-cell activation, and allows them to travel to the site of the tumor to destroy cancer cells. 

Side effects of Imfinzi (Durvalumab)

This medicine may cause some serious and unwanted side effects. Which requires immediate medical attention otherwise it can also lead to higher risk. Do not forget to discuss the risk and benefits of this medication with your doctor. 

Common side effects 

  • Chest pain 

  • Stuffy nose 

  • Muscle pain 

  • Cough 

  • Weakness 

  • Nausea 

  • Rash 

  • Painful urination 

  • Vomiting 

  • Decreased appetite

  • Swelling in your arms and legs 

  • Weight loss 

  • Shortness of breath 

  • Feeling tired 

  • Blurred vision 

  • Sore throat 

  • Fatigue 

  • Infection 

  • Fever 

  • Diarrhea 

  • Decreased sodium level

  • Abdominal pain 

  • Colitis 

  • Lower white cell count 

Serious side effects

  • Lung problems 

  • Kidney problems 

  • Skin problems 

  • Liver problems 

  • Severe infections 

  • Intestinal problems 

  • Hormone gland problems 

  • Problems in other organs 

  • Severe infusion reaction 

Note- If you experience any symptoms, please consult your medical advisor. 

Dosage

Use this injection as prescribed by your doctor. Do not take this medicine in the wrong way and make sure to take this medication according to your dosing schedule. 

 

Missed dose 

  • In case you missed a dose, immediately contact your doctor. It is important to take the dose of this medicine as scheduled. 

Overdose 

  • Emergency medical treatment is required. Please contact your medical advisor in case of an overdose. 

Usage of Imfinzi (Durvalumab)

This medication is used to treat non-small cell lung cancer and also used to treat a certain type of bladder cancer. This medicine works by helping your immune system to fight cancer. This medicine is given by your doctor or nurse. It is injected slowly in your vein and it lasts for 60 minutes. This medicine is given once every 2 to 4 weeks. Your medical advisor will decide the exact dosage and your dosing schedule. Try not to miss your dosing schedule and do not take an extra dose of this medicine. 

Warnings

Before starting treatment with the Imfinzi injection, do not forget to discuss your previous medical history with your doctor. 

  •  Contraception 

    • Use effective methods of contraception to prevent pregnancy while taking this medicine. 

  • Children and adolescents 

    • This medicine is not advisable for use in children and adolescents. 

Warnings for female 

  • Pregnancy 

    • Imfinzi injection shouldn’t be used by women who are pregnant. It is recommended that this medication should be avoided during pregnancy. 

  • Breastfeeding 

    • This medicine is not recommended for use in breastfeeding women unless it is necessary. Please consult your doctor. 

General warning and precautions 

  • This medicine should be administered by your doctor or nurse. 

  • Do not receive any vaccination without your doctor’s approval while taking this medicine. 

  • Avoid contact with people who have infections. 

  • Do not use this medicine if you have allergies. 

  • Do not drive if you experience any symptoms of dizziness.

  • This medicine may decrease the white blood cell count.

Cautions

  • Do not freeze or shake the solution. 

  • Not safe for pregnant women.

  • May harm your liver 

  • Do not breastfeed during the treatment with Durvalumab. 

Q1. What is Imfinzi (Durvalumab) 

Ans. This medicine is used for the treatment of non-small cell cancer. This medicine is given when cancer has spread to other areas of the body. 

Q2. How does Imfinzi work? 

Ans. Imfinzi is an immunotherapy that works by helping your immune system to fight cancer. This medicine blocks the action of PD-L1, exerts its anticancer effects by increasing T-cell activation, and allows them to destroy cancer cells. 

Q3. How should I take this medicine? 

Ans. This medicine is given by your doctor or nurse. It is injected slowly into your vein. This infusion usually lasts 60 minutes and this medicine is given once every 2 to 4 weeks.

Q4. In what strength is it available?

Ans. It is available in the strength of 500mg/10ml. 

Q5. What are the common side effects? 

Ans. Some common side effects are- nausea, mouth sore, chest pain, muscle pain, weakness, weight loss, vomiting, shortness of breath, blurred vision, infection, rashes, fever, etc.

Q6. What should I avoid while receiving this medicine? 

Ans. Follow your doctor’s advice about any restrictions. 

Q7.What is immunotherapy? 

Ans. Immunotherapy is a type of cancer treatment that works with the immune system to find and attack the cancer cell. 

Q8. What happens if I miss a dose? 

Ans. It is not advisable to miss a dose, please contact your medical advisor in case you miss a dose. 

Q9. What are the self-care tips? 

Ans. Keep yourself hydrated and maintain good nutrition. 

Q10. Can I consume alcohol while taking this medicine? 

Ans. It is not known whether it is safe or not. It may cause drowsiness consuming alcohol with Imfinzi injection. Please consult your doctor before consuming alcohol. 

Q11. Can I drive after taking this medicine? 

Ans. This medicine may cause dizziness which affects your ability to drive and concentrate. 

Q12. Can I take this medicine during pregnancy? 

Ans. This medicine is not recommended for pregnant women. 

Q13. Can I take this medicine during breastfeeding? 

Ans. This medicine is not recommended for use in breastfeeding women unless it is necessary. 

Q14. What are the storage conditions? 

Ans. Store this medicine in a refrigerator. Do not shake or freeze.

Interactions

Interactions may change how your medication works and increase the risk for side effects. Discuss with your doctor about your previous medical history.

Medicine interaction 

  • Adalimumab 

  • Fingolimod 

  • Tofacitinib 

  • Azathioprine 

  • Cortisone 

  • Omacetaxine 

  • Histoplasmin 

Disease interaction 

  • Diabetes 

  • Colitis 

  • Renal dysfunction 

  • Infection 

  • Liver dysfunction 

  • Thyroid disorders

  • Adrenal insufficiency 

Alcohol interaction 

  • Interaction with alcohol is unknown. Please contact your doctor before consuming alcohol. 

Contraindications

  • Imfinzi injection is not recommended for use in patients with a known allergy to Durvalumab. 

  • This medicine is contracted in patients with known hypersensitivity to Durvalumab.

Above Content has been reviewed by Professionals