PEMETA

Mfd. by :- Cipla (Fulfilled By : Magicine Pharma)

Pemeta

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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PACKAGE

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Brand name:- Pemeta  

Generic name:- Pemetrexed

Manufacturer:- Cipla 

Dosage form:- Injection

Strength:- 500mg 

Composition:- Pemetrexed

Packaging:- 1vial 

Indication:- Lung cancer

Storage:- Store in a refrigerator 

Overview

Pemeta (Pemetrexed) injection is used in the treatment of non-small cell lung cancer. This injection works by disrupting the cancer cell multiplication. This medication is given by your doctor or nurse. Take this medicine according to your doctor’s dosing schedule. Do not take this medicine in the wrong way as it may lead to some severe side effects. Close monitoring of blood cell count and kidney function is required during treatment with this medicine. Your dosage will depend on the medical condition and your response to the treatment. 

Pharmacodynamics of Pemeta (Pemetrexed)

 Pemeta inhibits the in vitro growth of mesothelioma cell lines (MSTO-211H, NCI-H2052). Pemetrexed is an antifolate containing the pyrrolopyrimidine-based nucleus that exerts its antineoplastic activity by disrupting the folate-dependent anti metabolic process essential for cell replication. Pemeta administered as a single agent in doses ranging from 0.2 to 838mg/m2 infused over a 10 minute period.

Substitutes of Pemeta (Pemetrexed)

  • Pemex 

  • Pemcure 

  • Pemotide 

  • Alimta

  • Temeran 

  • Zupemed 

Side effects of Pemeta (Pemetrexed)

This medicine may cause some serious and unwanted side effects. Which requires immediate medical attention otherwise it can also lead to higher risk. Do not forget to discuss the risk and benefits of this medication with your doctor. 

Common side effects 

  • Diarrhea 

  • Cough 

  • Hair loss 

  • Sore throat 

  • Loss of appetite 

  • Rash 

  • Anemia 

  • Shortness of breath 

  • Abdominal pain 

  • Redness of skin 

  • Chest pain 

  • Bleeding 

  • Feeling tired 

  • Weight loss 

  • Constipation

  • Pale skin 

  • Cough 

  • Neuropathy 

  • Stomatitis 

  • Redness of skin 

  • Itching 

  • Pain and tears in eyes. 

Serious side effects  

  • Fever and chills 

  • Nausea 

  • Mouth ulcers 

  • Skin rash 

  • Decreased urine output 

  • Blood in urine and stools 

  • Vomiting 

  • Low white blood cell 

  • Reduced  platelet 

Note- please contact your doctor if any side effect occurs.

Dosage

Use this injection as prescribed by your doctor. Do not take this medicine in the wrong way and make sure to take this medication according to your dosing schedule. Dose administration should be decided by your doctor according to your response to the treatment. 

 

Missed dose 

  • In case you missed a dose, immediately contact your doctor. It is important to take the dose of this medicine as scheduled by your medical advisor. 

Overdose 

  • Emergency medical treatment is required. Please contact your medical advisor in case of an overdose. 

Usage of Pemeta (Pemetrexed)

Pemetrexed is given as an infusion into the vein. This medication is usually given every 3 weeks. This medicine works by interfering with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents cancer cells from multiplying. Disclose your previous medical history with your medical advisor before starting treatment with this medicine. Take this medicine prescribed by your doctor and try not to miss your dosing schedule. Protect this medicine from heat and light. 

Warnings

Before starting treatment with the Pemeta injection, do not forget to discuss your previous medical history with your doctor. 

 

  •  Contraception 

    • Use effective methods of contraception to prevent pregnancy while taking this medicine. 

  • Children and adolescents 

    • This medicine is not advisable for use in children and adolescents. 

 

Warnings for female 

  • Pregnancy 

    • Pemeta injection shouldn’t be used by women who are pregnant. It is recommended that this medication should be avoided during pregnancy. 

 

  • Breastfeeding 

    • This medicine is not recommended for use in breastfeeding women unless it is necessary. Please consult your doctor.

General warning and precautions 

  • This medicine decreases the platelets count. Close monitoring of blood cell count is required with this treatment.

  • This medication may cause serious skin reactions 

  • This medicine increases the risk of infection. 

  • Close monitoring of kidney function is required with this treatment. 

Cautions

  • Do not freeze or shake the solution. 

  • Not safe for pregnant women.

  • It may harm your kidney function. 

  • Do not breastfeed during the treatment with Pemeta.

Q1. What is Pemeta (Pemetrexed)? 

Ans. This medication is used in the treatment of non-small cell lung cancer or malignant pleural mesothelioma (a form of lung cancer). 

Q2. How does Pemeta injection work? 

Ans. This medicine interferes with the growth of DNA and RNA of cancerous cells by substituting their building blocks. It stops the growth of cancer cells. 

Q3. How to use this medication? 

Ans. This injection is administered in your vein by your doctor or nurse. Make sure to take the dose according to your dosing schedule. 

Q4. What are the common side effects? 

Ans. Some common side effects are:- constipation, weight loss, fever, abdominal pain, cough, diarrhea, chest pain, shortness of breath, bleeding, pale skin. 

Q5. In what strength is it available? 

Ans. It is available in the strength of 500mg. 

Q6. What should I avoid while receiving this medicine? 

Ans. Follow your doctor’s instructions about any restriction.

Q7 How long does the effect of this medicine last? 

Ans. The effect of this medicine usually lasts for about 6 to 9 hours. 

Q8. What are the self-care tips? 

Ans. Maintain good nutrition and keep yourself hydrated during treatment with this medicine.

Q9. Can I take this medicine during pregnancy? 

Ans. This medicine is not recommended for pregnant women. 

Q10. Can I consume alcohol while taking this medicine? 

Ans. Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol

Q11. Can I drive after taking this medicine? 

Ans. Do not drive if you experience any symptoms of dizziness because it may affect your ability to drive. 

Q12. Can I take this medicine during breastfeeding? 

Ans. This medicine is not recommended for use in breastfeeding women unless it is necessary. 

Q13. What are the storage conditions? 

Ans. Store this medicine in the refrigerator. Do not freeze or shake the medicine.   

Q14. What if I miss a dose? 

Ans. In case you miss a dose, immediately contact your doctor.

Interactions

Interactions may change how your medication works and increase the risk for side effects. Don’t forget to discuss your previous medical history with your medical advisor. 

Medicine interaction 

  • Clozapine 

  • Ativan 

  • Fluoroquinolone antibiotics

  • Methotrexate 

  • Norco 

  • Ativan 

Disease interaction 

  • Renal dysfunction 

  • Myelosuppression 

  • Liver dysfunction 

Alcohol interaction 

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol. 

 

Contraindications

  • Pemeta injection is not recommended for use in patients with known allergy to pemetrexed

  • This medicine is contracted in patients with known hypersensitivity to pemetrexed.

 

Above Content has been reviewed by Professionals