
Prolia 60mg Injection
Salt Composition: Denosumab
Expiry Date: 01/2028
Inclusive of all taxes
1 Injection
About The Product
- Postmenopausal Osteoporosis
- Male Osteoporosis
- Steroid-Induced Bone Loss
- Bone Loss in Men/Women on Cancer Therapy
Prolia 60mg Injection is used in the treatment of osteoporosis (bone loss) in patients who have a very high risk of bone fracture. Osteoporosis mostly happens in women after menopause, making it more likely to break easily.
This medicine maintains bone density by slowing down bone loss and decreasing the risk of bone fractures. It belongs to the monoclonal antibodies class. It can also be used by males.
Uses
- Postmenopausal Osteoporosis
- Male Osteoporosis
- Steroid-Induced Bone Loss
- Bone Loss in Men/Women on Cancer Therapy
Side Effects
The human body reacts differently to Prolia 60mg Injection. Response or undesired symptoms vary from individual to individual. Usually, they disappear with time as the body adjusts to the medicine; these side effects don't need special medical attention. Whereas if the symptoms don't disappear with time or you have severe side effects, then consult your doctor immediately. Some of the common side effects of Prolia 60mg Injection are mentioned below:
- Rash
- Sciatica
- Musculoskeletal (bone, muscle, or joint) pain
- Infection in the upper respiratory tract
- Hair loss
- Headache
- Nerve pain
- Constipation
- Eczema
- Urinary tract infection
- Hypercholesterolemia (high cholesterol)
- Cystitis
- Fatigue
- Hypocalcemia
How To Use
- The Prolia 60mg injection is injected in your upper thigh, stomach, or upper arm. Normally, you get it every 6 months.
- For more information, talk to your doctor. This injection should not be self-administered and should be given by a health care professional.
- To make it more effective, take a balanced diet and take an adequate amount of Vitamin D and calcium while on treatment with Prolia 60mg injection.
How It Works
The Prolia 60mg injection is a monoclonal antibody. It prevents bones from getting fractures or reduces the risk of bone loss by binding to a protein that weakens the bone.
As a result, bones get strengthened, and the risk of fractures is minimized.
Safety Advice
The interaction of alcohol with this drug is still unknown. It is advisable not to consume alcohol while taking Prolia 60mg injection. Consult your doctor for further information.
Prolia 60mg injection may be considered unsafe during pregnancy. Please consult your doctor in such a condition. According to some research data, taking Prolia 60mg injection during pregnancy has shown harmful effects on the developing baby.
Prolia 60mg injection is probably not safe if you're breastfeeding. Kindly consult your doctor before taking Prolia 60mg injection while breastfeeding, as there are chances that it may pass to the developing baby through the breast milk of the mother.
It is not advisable to drive or operate heavy machinery after taking the Prolia 60mg injection, as you may feel dizzy.
Share your medical history with your healthcare expert in case of kidney disease before taking Prolia 60mg injection. Patients with renal impairment must be careful while taking Prolia 60mg injection. They may require adjustment in the dose.
Inform your doctor before starting Prolia 60mg injection if you have liver disease to avoid any serious side effects. Patients with hepatic impairment must be careful while taking Prolia 60mg injection. They may require adjustment in the dose.
Missed Doses
- It is advisable not to miss any dose.
- In case you miss a dose of Prolia 60mg Injection consult your doctor soon.
- Missing the dose will impact the overall health of the patients.
- So, it is always advisable to follow the prescription of the doctor strictly.
FAQs
Prolia 60mg injection increases the bone density accordingly cancer cells.
References
- Green W. (2024). Denosumab (Prolia) Injection: A New Approach to the Treatment of Women With Postmenopausal Osteoporosis. P T, 35(10):553–9 - https://pmc.ncbi.nlm.nih.gov/articles/PMC2957751/
- Aubin JE, Bonnelye E. (2025). Osteoprotegerin and its ligand: A new paradigm for regulation of osteoclastogenesis and bone resorption. Osteoporos Int. 11:905–913 - https://pubmed.ncbi.nlm.nih.gov/11193242/
- Sattler A, Schoppet M, et al. Novel aspects on RANK ligand and osteoprotegerin in osteoporosis and vascular disease. Calcif Tissue Int. 74:103–106 - https://pubmed.ncbi.nlm.nih.gov/14523602/
- Nicolopoulos K, Moshi MR, Stringer D, Ma N, Jenal M, Vreugdenburg T. (2025). The clinical effectiveness of denosumab (Prolia®) in patients with hormone-sensitive cancer receiving endocrine therapy, compared to bisphosphonates, selective estrogen receptor modulators (SERM), and placebo: a systematic review and network meta-analysis. Arch Osteoporos. 10;18(1):18.
- Jamshidi, A., Vojdanian, M., Soroush, M. et al. (2025). Efficacy and safety of the biosimilar denosumab candidate (Arylia) compared to the reference product (Prolia®) in postmenopausal osteoporosis: a phase III, randomized, two-armed, double-blind, parallel, active-controlled, and noninferiority clinical trial. Arthritis Res Ther 24, 161 - https://pubmed.ncbi.nlm.nih.gov/35773713/
- Francisco A. (2024). Sylvester, Effects of Digestive Diseases on Bone Metabolism. Pediatric Gastrointestinal and Liver Disease, (1116-1125.e8).
- Savelli,G.,Oliviero,S.,Viceconti,M.,Mattina,M,L,A., (2025). In silico prediction of hip fractures: improved fall modeling and expanded validation across cohorts with diverse risk profiles, Journal of the Mechanical Behavior of Biomedical Materials, 172, (107182) -https://pubmed.ncbi.nlm.nih.gov/40913997/
- Singh, Inderjeet; Jose, Vinu; Patel, Ronak; Arora, Sumit INTP23. (2025). Study 051-14 Investigator Team. Denosumab biosimilar in postmenopausal osteoporotic women: A randomized, assessor-blind, active-controlled clinical trial. Indian Journal of Pharmacology 53(1):p 6-12.
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