REBIF

Mfd. by :- Pfizer (Fulfilled By : Magicine Pharma)

rebif

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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PACKAGE

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Medicine details

Brand name - Rebif
Generic name - Interferon beta-1a
Manufacturer - Pfizer
Salt composition - Interferon beta-1a
Storage - Store between 36°F and 46°F
Dosage form - Injection (subcutaneous use)
Active ingredient - Interferon beta-1a
Strength - 22mcg/0.5mL or 44mcg/0.5mL
Packaging - Pre-filled syringes
Gender - Unisex
Indication - Treatment of relapsing Multiple Sclerosis (MS) in adults

Description

Rebif is a form of protein called beta interferon that is produced in the body. Rebif (Interferon beta-1a) injection is a prescription medicine indicated for the treatment of relapsing forms of Multiple Sclerosis in adults (aged over18). It is not known if Rebif injection is safe and effective in children. Interferon beta-1a is an immunomodulator. It works to lower the chances of Multiple Sclerosis (MS) by reducing the inflammation, affecting the functioning of the immune system and preventing further nerve damage. Rebif (Interferon beta-1a) may also be known as a disease-modifying drug.

Pharmacodynamics

Pharmacotherapeutic group: Immunostimulants, Interferons, ATC code: L03AB07

Interferons are a group of endogenous glycoproteins, that are bestowed with immunomodulatory, antiviral and antiproliferative properties. Rebif (interferon beta-1a) shares the same amino acid sequence with endogenous human interferon beta.

The efficacy of Rebif has been calculated in patients with relapsing-remitting Multiple Sclerosis at certain doses ranging from 11 to 44 micrograms (3-12 million IU), administered subcutaneously (three times per week). Rebif 22 mcg has been observed to minimize the incidence (approximately 30% over 2 years) and severity of clinical relapses in patients with at least 2 exacerbations in the previous 2 years along with an EDSS of 0-5.0 at entry. The average count of patients with disability progression, as defined by at least one point increase in EDSS confirmed three months later, was decreased from 39% (placebo) to 30% (Rebif 22 mcg).

Ingredients

The active ingredient in Rebif injection is Interferon beta-1a, and the inactive ingredients are albumin (human), mannitol, sodium acetate and water for injection.

Usage of medicine

Rebif injection (Interferon beta-1a) is used in the treatment of relapsing multiple sclerosis (MS) in adults, aged over 18.

 

Side-effects

It is advised to seek immediate help from a professional healthcare provider, if you experience any of the following or other side effect(s).

Common side-effects

  • Stomach ache

  • Fever

  • Chills 

  • Cough

  • Chest pain

  • Back pain

  • Weakness

  • Unusual tiredness

  • Muscle pain

  • Depression

  • Skin rash

  • Headache 

  • Low count of blood cells

  • Unusual bleeding

  • Joint pain

  • Painful urination

  • Mouth ulcers

  • Sores on the lips or in the mouth

  • Shortness of breath

  • Black stools 

  • Itching 

Less common side-effects

  • Drowsiness

  • Fainting

  • Swelling on face

  • Mood changes

  • Redness of skin

  • Hearing problem

  • Sneezing

  • Runny nose

  • Pain in vagina with discharge

  • Sore throat

Rare side-effects

  • Pale skin

  • Loss of appetite

  • Dry skin

  • Fast heartbeat

  • Weight loss or gain

  • Unusual sweating

  • Overactive bladder

  • Heavy bleeding during menstruation

  • Hair loss

  • Trouble sleeping

  • Indigestion 

  • Nervousness

  • Nose bleeding

Dosage

Normal dose

There are three available options for injecting Rebif (Interferon beta-1a). Your healthcare provider will recommend the dose according to your medical condition and requirement. There are two dosing options available: 22mcg and 44mcg.There are three available options for injecting Rebif (Interferon beta-1a). Your healthcare provider will recommend the dose according to your medical condition and requirement. There are two dosing options available: 22mcg and 44mcg. 

Missed dose

Contact your healthcare provider for further instructions if you miss a dose.

Overdose

Seek emergency medical help.

 

Warning and precautions

  • Avoid consuming alcohol with Rebif injection. 

  • In case of patients who already have depression disorders, Rebif injection should be administered with caution.

  • Patients with cardiac disease and thyroid disorders should be closely monitored and cautiously administered.

  • There may be a risk of spontaneous abortion in case of pregnancy. Please consult your healthcare provider before taking Rebif (Interferon beta-1a) injection.

Contraindications

  • Hypersensitivity to any of the ingredients of Rebif injection.

  • Severe depression and/or suicidal thoughts.

FAQs

Q1- What is Rebif (Interferon beta-1a)?

A- Rebif injection (Interferon beta-1a) is used in the treatment of relapsing multiple sclerosis (MS) in adults, aged over 18.

Q2- How should I take Rebif injection?

A- Rebif injection is administered subcutaneously.

Q3- What are the possible side-effects of Rebif (Interferon beta-1a)?

A- Rebif may cause allergic reactions on the injection site. There can be other side effects like fever, chills, nausea, dizziness, ear pain, stomach pain, muscle and joint pain. Please seek medical help if you experience these or other side effects.

Q4- In what strength is Rebif available?

A- Rebif injection is available in the strength of 22mcg/0.5mL or 44mcg/0.5mL.

Q5- What should be done if I miss a dose?

A- Seek professional medical advice if you miss a dose.

Q6- What should I avoid while consuming this medicine?

A- Avoid consuming alcohol with Rebif injection. 

Q7- What are self care tips?

A- Tell your healthcare provider immediately if you experience sudden mood changes or suicidal thoughts.

Q8- Can I take this medicine during pregnancy?

A- Before taking Rebif injection, please consult your healthcare provider.

Q9- Can I drive after taking Rebif injection?

A- If you feel dizzy after taking Rebif injection, avoid driving and operating heavy machines.

Q10- What are the storage conditions for Rebif (Interferon beta-1a) injection?

A- Store Rebif in the refrigerator between 36°F to 46°F. Do not freeze. Keep Rebif away from heat, light and children.

 

Above Content has been reviewed by Professionals