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Afanat 40mg tablets

4.8
Google Rating

Prescription Required

Marketed By

Natco

Pack of

28 Tablet in Bottle

Salt Composition

Afatinib

Storage

Keep in cold place

shipping-zone

Delivering To:

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Overview

  • The Afanat 40 mg tablet, which comprises afatinib, is a molecular anticancer medication indicated for first-line therapy in patients with metastatic non-small cell lung cancer (NSCLC) harboring non-resistant EGFR gene mutations.
  • Moreover, Afanat is used in metastatic squamous NSCLC that has advanced after chemotherapy with platinum medication.
  • Afanat acts as a kinase inhibitor by targeting protein kinases associated with the development of cancerous cells. Therefore, it inhibits the proliferation of cancer cells, thus prolonging disease progression and survival periods, and alleviates symptoms such as pain.
  • However, it should be administered orally once a day, preferably on an empty stomach at least one hour prior to or two hours following a meal.
  • Moreover, the medicine should only be utilized under the guidance of an oncologist.
  • Side effects associated with the use of Afanat include diarrhea, rash or acne, dry skin, nail infection, mucositis, and loss of appetite.
  • It should be avoided if there is liver disease, renal dysfunction, eye disease, or respiratory conditions, particularly if pregnant or breastfeeding.

Indication

Metastatic Non-Small Cell Lung Cancer (NSCLC)

Uses

Treatment of metastatic non-small cell lung cancer (NSCLC) with specific non-resistant epidermal growth factor receptor (EGFR) mutations

Side Effects

Afanat 40mg tablets may cause some side effects that vary from one patient to another. Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Seek medical attention in case of any unusual or severe side effects immediately. Side effects include:

  • Diarrhea (can be severe, leading to dehydration)
  • Nausea and vomiting
  • Loss of appetite
  • Fatigue or weakness
  • Abdominal or stomach pain
  • Mouth sores (stomatitis)
  • Skin rash, acne, dryness, or itching
  • Nail changes or infections
  • Injection site reactions (pain, redness, swelling)
  • Headache
  • Dizziness
  • Fever and chills
  • Respiratory infections or pneumonia (with chest pain or breathlessness)
  • Eye irritation, dryness, or more serious issues like corneal damage
  • Liver problems
  • Kidney problems
  • Cardiac complications
  • Low potassium levels in the blood
  • Unexpected bleeding (blood in stool or urine)
  • Allergic reactions (swelling of lips, itching, rash)
  • Seizures, loss of consciousness, or bleeding in the brain
  • Frequent urination with pain or burning sensation

How To Use

  • ​Use this medicine according to the dose and duration prescribed by your physician.
  • Take it in its whole form without crushing or breaking.
  • This tablet must be used on an empty stomach.

Safety Advice

Alcohol

CONSULT YOUR DOCTOR

Consult your doctor, as the interaction of alcohol with this tablet is still unknown, but you should avoid the consumption of alcohol while taking Afanat 40mg tablets.

Pregnancy

UNSAFE

Do not take Afanat 40mg tablet during pregnancy, as it is a highly unsafe medicine for the fetus.

Breast Feeding

UNSAFE

Afanat 40mg tablet is unsafe to use during breastfeeding as it may cause toxicity to the baby.

Driving

DANGER

Afanat 40mg tablets may cause side effects such as dizziness or lack of concentration, which could affect your ability to drive. So it's better to avoid driving or operating heavy machinery.

Kidney

PRECAUTION

Consumption of Afanat 40mg tablets should be avoided without informing the doctor if you have any kidney-related issues.

Liver

PRECAUTION

Consumption of Afanat 40mg tablets should be avoided without informing the doctor if you have any liver-related issues.

Missed Doses

  • It is advisable to avoid missing any doses.
  • In case you miss a dose of Afanat 40mg tablets consult your doctor immediately.
  • In case you forget to take your dose of Afanat 40 Tablet, take it as soon as you remember.
  • But if it is near the time for your next dose, avoid taking the missed dose and resume with your normal routine.

Quick Tips

  • The prescription for Afanat 40 Tablet is meant for treating certain kinds of lung cancer (non-small cell lung cancer).
  • Take Afanat 40 Tablet on an empty stomach, either at least 1 hour before meals or 2 hours after a meal.
  • Diarrhea is a common side effect of Afanat 40 Tablet. Diarrhea may be severe in some cases. Your doctor may prescribe medicines to manage diarrhea. Ensure that you stay well-hydrated and follow the dosage guidelines carefully.
  • Skin sensitivity to sunlight exposure is a possible adverse effect of Afanat 40 Tablet. Limit your exposure to the sun whenever possible. Apply sunscreen, and dress accordingly to protect yourself when in the sun.
  • Redness, rash, and acne may occur as a result of taking Afanat 40 Tablet. Take prompt measures against any skin reaction.
  • Practice contraception throughout your use of this tablet and one month after you stop using it.
  • Keep track of your blood pressure consistently while on this medication. Alert your healthcare provider if you experience signs of high blood pressure like severe headaches, confusion, visual impairment, nausea, and vomiting.
  • You should avoid using this medicine during pregnancy, when planning to become pregnant, or when breastfeeding.
  • This medicine is prescribed for the management of thyroid cancer.
  • Employ effective birth control methods during the use of this medicine and even one month after stopping the use of this medicine.
  • Check your blood pressure levels while using this tablet.
  • Consult your physician if you have any symptoms of hypertension such as extreme headaches, confusion, visual impairment, nausea, or vomiting.
    It can lead to bleeding disorders.
  • Seek medical advice if you suffer from headaches, abdominal pain, blood in your feces or urine.

FAQs

What are Afanat 40mg tablets used for?

Afanat 40mg tablet is an anticancer medicine that is used in the treatment of non-small cell lung cancer.


Are Afanat 40mg tablets safe to take during pregnancy?

​It is advisable to avoid the Afanat 40mg tablet during pregnancy as it can cause harm to the fetus.


Can I drive after taking Afanat 40mg tablets?

​It is advisable to avoid driving and operating heavy machinery while taking Afanat 40mg tablets, as it may cause dizziness.


How long is the treatment duration with Afanat 40mg tablets?

​The doctor decides the course of treatment with Afanat 40mg tablets depending on the stage of the cancer and the health of the patient.


How can I take the Afanat 40mg tablet?

Afanat 40mg tablets should be taken orally without meals. However, it is advisable to follow the prescription given by the doctor.


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References

  • Joshi, M., Rizvi, S. M., & Belani, C. P. (2015). Afatinib for the treatment of metastatic non-small cell lung cancer. Cancer management and research, 75-82.
  • Kumar, S., & Agrawal, R. (2014). Next generation tyrosine kinase inhibitor (TKI): afatinib. Recent patents on anti-cancer drug discovery, 9(3), 382-393.
  • Kim, Y., Lee, S. H., Ahn, J. S., Ahn, M. J., Park, K., & Sun, J. M. (2019). Efficacy and safety of afatinib for EGFR-mutant non-small cell lung cancer, compared with gefitinib or erlotinib. Cancer research and treatment: official journal of Korean Cancer Association, 51(2), 502-509.
  • Giordano, P., Manzo, A., Montanino, A., Costanzo, R., Sandomenico, C., Piccirillo, M. C., ... & Morabito, A. (2016). Afatinib: An overview of its clinical development in non-small-cell lung cancer and other tumors. Critical reviews in oncology/hematology, 97, 143-151.
  • Saber, A., Hiltermann, T. J. N., Kok, K., & Groen, H. J. M. (2016). Resistance mechanisms after tyrosine kinase inhibitors afatinib and crizotinib in non-small cell lung cancer, a review of the literature. Critical reviews in oncology/hematology, 100, 107-116.

Ratings And Reviews

4.8
Google Rating

4.80/5

5 Ratings

5

80.00%

4

20.00%

3

0.00%

2

0.00%

1

0.00%

William Martin

Great product for daily use

Outstanding product! Afanat 40mg tablets has exceeded my expectations. The quality is excellent and it's been working perfectly. Delivery was on time and everything was well-packaged. Highly recommend!

a year ago

Sophia T.

Good quality for the price

Good product overall. Afanat 40mg tablets works well and the quality is decent. Delivery was on time and packaging was okay. Satisfied with the purchase and would consider buying again.

a year ago

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MARKETER DETAILS

Natco

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The contents of this website are for informative purposes only. They are not deliberated to be an alternative to any professional medical prescription and treatment. Seek the advice of a qualified health provider for questions regarding the medical condition. Do not ignore any professional medical advice because of something you have read on this website. This website offers links to other websites, thereby enabling you to go to the other website directly. Therefore, Magicine Pharma isn't responsible for the content of the links in the website or links in the linked websites. The links are provided to assist the visitors and are not approved by any professional health provider.