DUOVIR

Mfd. by :- Cipla (Fulfilled By : Magicine Pharma)

Duovir

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name: Duovir 
Generic Name: Lamivudine and Zidovudine
Manufacturer: Cipla 
Dosage Form: Tablet 
Strength: 150mg/300mg 
Composition:  Lamivudine(150mg) and Zidovudine(300mg)
Indication: HIV 
Packaging: 60 tablets 
Storage: Store at room temperature

Overview

Duovir (Lamivudine and Zidovudine) tablet is a combination of two antiretroviral medications. It is used for the treatment of HIV (human immunodeficiency virus) infection. This medication boosts your immune system to fight against infection and prevents the virus from multiplying. Duovir tablet increases the CD4 cell (white blood cells that protect against infection) count in your blood. It is important to take this medicine as prescribed by your doctor. Do not take this medicine in the wrong way as it may lead to some serious side effects. If you experience any signs and symptoms while receiving this medicine, inform your doctor immediately.

Pharmacodynamics

Lamivudine (Duovir):- A nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) in order to disrupt viral DNA synthesis. It can form active metabolites when phosphorylated, that compete for incorporation into viral DNA. Via DNA incorporation, lamivudine metabolites work to inhibit the activity of the HIV reverse transcriptase enzyme and then act as a chain terminator of DNA synthesis.

Zidovudine (Duovir):- Works to inhibit the activity of HIV-1 reverse transcriptase by competing with its natural nucleotide counterpart thymidine triphosphate for incorporation into newly synthesized viral DNA. It is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). This compound is phosphorylated to active metabolites that compete for incorporation into viral DNA. They work to inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis.

Usage 

Duovir tablet is a combination of two anti-HIV medicines: Lamivudine and Zidovudine. It helps to delay the production of HIV infection and improves the quality of life. Duovir tablets are not a permanent cure for HIV infection. This medication only prevents the multiplication of HIV (human immunodeficiency virus) infection in human cells. It is advisable not to change your regular dosing schedule without taking suggestions from your doctor. The recommended dose of Duovir medicine is decided by a doctor according to your previous medical condition and response to the treatment. Store this medicine at room temperature and keep it away from direct heat and light. 

Interactions 

Duovir tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions 

  • Clozapine 

  • Etodolac 

  • Fenofibrate 

  • Methotrexate 

  • Atorvastatin 

Disease Interactions 

  • Renal dysfunction 

  • Bone marrow suppression 

  • Myopathy 

Alcohol Interaction

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.

Contraindication

  • Do not take this medicine if you are allergic to Lamivudine and Zidovudine.

  • Duovir tablet is not recommended in patients known to be hypersensitive.

  • This medicine is not recommended for use in patients with severe liver disease. 

 

Side effects 

This medicine may cause some common side effects. Discuss the risks and benefits of the Duovir tablets with the doctor before starting the treatment.

  • Unusual weakness 

  • Blurred vision 

  • Loss of weight

  • Nausea

  • Insomnia

  • Diarrhea

  • Blood in urine

  • Irregular heartbeat

  • Abnormal dream 

  • Confusion 

  • Indigestion 

  • Constipation

  • Redness of skin

  • Taste changes 

  • Unusual tiredness 

  • Fever 

  • Chills 

  • Loss of strength 

  • Fatigue 

  • Sore throat 

  • Swollen lymph nodes

  • Loss of appetite 

  • Seizures 

  • Cough 

Note - immediately contact your health care provider or medical practitioner if any side effects occur.

 

Dosage 

Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing schedule. 

Missed dose 

  • It is advisable not to miss a dose. If you miss a scheduled dose of Duovir tablets, contact your doctor immediately. 

Overdose 

  • In case of an overdose of Duovir tablets, the doctor will provide emergency medical treatment.

Warnings 

Before starting treatment with Duovir medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk. 

  •  Contraception 

    • Use suitable methods of contraception to prevent pregnancy while taking Duovir medicine. 

  • Children and adolescents 

    • Duovir tablets are not recommended for use in children under the age of 18. 

Warnings for female 

  • Pregnancy

    • Do not use Duovir medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy. 

  • Breastfeeding

    • This medicine is not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment with Duovir (Lamivudine and Zidovudine). 

Precautions 

  • Inform your doctor if you experience any side effects like- nausea, insomnia, fever, sore throat, headache, abnormal dream, anxiety, etc.

  • This medication may increase the risk of immune reconstitution syndrome. 

  • Close monitoring of bone mineral density is required during treatment with this medicine.

  • Duovir tablet may increase the risk of lactic acidosis. 

Cautions 

  • Do not drive or operate heavy machinery.

  • Do not crush or break the tablet. 

  • Not safe for pregnant women. 

  • Do not breastfeed while receiving this medication.

Q1. What is Duovir?

Ans. Duovir tablet is a combination of two anti-HIV medicines: Lamivudine and Zidovudine. It is an antiviral medication that prevents the human immunodeficiency virus (HIV) from multiplying in your body. It also helps to delay the production of HIV infection and improves the quality of life.

Q2. What are the side effects?

Ans. Some common side effects are:- fatigue, sore throat, headache, nausea, taste change, stomach ache, peripheral neuropathy, diarrhea, fever, chills, blurred vision, weight loss, abnormal dreams, etc.

Q3.  In what strength is it available? 

Ans. Duovir tablet is available in the strength of 150mgg/300mg. 

Q4. How does Duovir (Lamivudine and Zidovudine) work?

Ans. This medication helps to boost your immune system to fight against infection and also increases the CD4 cell (white blood cells that protect against infection) count in your blood.

Q5. Can I take this medicine during pregnancy? 

Ans. This medicine is not recommended during pregnancy.

Q6. What should I avoid while receiving this medication? 

Ans. Follow your doctor’s advice about any restrictions on food and other activities.

Q7.  How to take this medicine?

Ans. It is important to take Duovir (Lamivudine and Zidovudine) tablet as prescribed by your doctor. 

Q8.  What happens if I miss a dose? 

Ans. If you miss a scheduled dose of Duovir tablets, contact your doctor immediately.

Q9. Can I drive after taking this medicine? 

Ans. This medicine may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur. 

Q10.  What are the self-care tips? 

Ans. Keep yourself hydrated and maintain good nutrition. 

Q11.  What are the storage conditions?

Ans. Store this medicine at room temperature. Keep it away from direct heat and light. 

Q12. Does this medicine affect liver function? 

Ans. Please consult your doctor before consuming this drug.

Q13. Can I consume alcohol while taking this medicine? 

Ans. It is not known whether it is safe or not. Please consult your doctor before consuming alcohol. 

 

Above Content has been reviewed by Professionals