
Glivec 400mg tablet
Salt Composition: Imatinib
Expiry Date: 01/2028
Inclusive of all taxes
10 tablet Per Strip
About The Product
- Chronic Myeloid Leukemia (CML)
- Acute Lymphocytic Leukemia (ALL)
- Gastrointestinal Stromal Tumors (GIST)
- Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
- Hypereosinophilic Syndrome (HES)
- Chronic Eosinophilic Leukaemia (CEL)
- Dermatofibrosarcoma Protuberans (DFSP)
Glivec 400 mg tablet is a medicine is used in the treatment of some forms of cancer. It is prescribed by doctors to treat blood cancers such as chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) and gastrointestinal stromal tumors (GIST). It acts by inhibiting special proteins (also referred to as tyrosine kinases) that assist cancer cells to multiply and grow. Glivec prevents the increase or even the progression of cancer cells by blocking signals. In addition to blood cancers and GIST, Glivec is employed to treat certain rare diseases like dermatofibrosarcoma protuberans (skin tumor) and aggressive systemic mastocytosis (a bone marrow disease).
Uses of Glivec tablet
- Chronic Myeloid Leukemia (CML)
- Acute Lymphocytic Leukemia (ALL)
- Gastrointestinal Stromal Tumors (GIST)
- Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
- Hypereosinophilic Syndrome (HES)
- Chronic Eosinophilic Leukaemia (CEL)
- Dermatofibrosarcoma Protuberans (DFSP)
Side Effects
This medicine can make your skin more sensitive to sunlight than usual. Sun exposure may lead to rashes, itching, redness, or even severe sunburn. To protect yourself outdoors, wear suitable clothing and apply sunscreen with an SPF of at least 15. If you notice a burning sensation on your skin, inform your doctor. The human body reacts differently to the Glivec 400mg tablet. Responses or undesired symptoms vary from individual to individual. Usually, they disappear with time as the body adjusts to the medicine; these side effects don't need special medical attention. Whereas if the symptoms don't disappear with time or you have severe side effects, then consult your doctor immediately. Some of the common side effects of the Glivec 400mg tablet are mentioned below:
- Diarrhea
- Vomiting
- Nausea
- Loss of appetite
- Dizziness
- Extreme fatigue
- Blurred vision
- Irregular heart rate
- Chest pain
- Muscle cramps
- Pink eye
- Redness and rashes, Swelling of joints
- Trouble sleeping
- Hair loss
- Shortness of breath
- Yellowing of eyes and skin
- Pink mucous in the cough
- Sudden weight loss or weight gain
- Peripheral edema
How To Use
- Take the dose of the Glivec 400mg tablet as per your healthcare provider’s prescription.
- Do not stop taking the medicine suddenly, unless your doctor tells you.
- This medicine is given under the strict supervision of a doctor. Do not self-administer.
- Overdose is a very unusual state for this medicine because it is given under the supervision of a healthcare provider.
- Glivec 400mg tablet can be taken without food or with food.
- The doctor will provide emergency medical treatment.
- You should not break, crush, or chew the medicine; it should be swallowed as a whole.
How It Works
The Glivec 400mg tablet is an anticancer medicine that acts as a tyrosine kinase inhibitor. Its mechanism of action involves selective inhibition of the protein kinase enzyme known as BCR-ABL, which promotes aberrant growth of cancerous cells.
The inhibition of the enzyme ensures the prevention of the multiplication of tumor cells, as well as the induction of apoptosis in cells with the positive BCR-ABL enzyme. Apart from the BCR-ABL enzyme, the drug inhibits other enzymes such as c-KIT and PDGFR.
Safety Advice
Missed Doses
- It is not advisable to miss any doses.
- In case you miss a dose of Glivec tablets, consult your doctor immediately.
FAQs
Glivec is an anticancer tablet that is primarily used in the treatment of blood cancer.
References
- Peng B, Dutreix C, Mehring G, Hayes MJ, Ben-Am M, Seiberling M, Pokorny R, Capdeville R, Lloyd P. (2024). Absolute bioavailability of imatinib (Glivec) orally versus intravenous infusion. J Clin Pharmacol. 44(2):158-62 - https://pubmed.ncbi.nlm.nih.gov/14747424/
- Zhu J, Yang Y, Zhou L, Jiang M, Hou M. (2024). A long-term follow-up of the imatinib mesylate treatment for the patients with recurrent gastrointestinal stromal tumor (GIST): the liver metastasis and the outcome. BMC Cancer. 10:199 - https://pubmed.ncbi.nlm.nih.gov/20465813/
- Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y, Kitamura Y. (2025). Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 279(5350):577–580 - https://www.scirp.org/reference/referencespapers?referenceid=2656333
- Corless CL, McGreevey L, Haley A, Town A, Heinrich MC. (2024). KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size. Am J Pathol. 160(5):1567–1572. - https://pubmed.ncbi.nlm.nih.gov/12000708/
- Mudan SS, Conlon KC, Woodruff JM, Lewis JJ, Brennan MF. (2025). Salvage surgery for patients with recurrent gastrointestinal sarcoma: prognostic factors to guide patient selection. Cancer. 88(1):66–74. - https://pubmed.ncbi.nlm.nih.gov/10618607/
- Demetri GD, von Mehren M, Blanke CD, Abbeele AD Van den, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H. (2024). Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 347(7):472–480.
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