IMACINE

Mfd. by :- Arechar Healthcare (Fulfilled By : Magicine Pharma)

Imacine

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name: Imacine
Generic Name: Imatinib mesylate
Manufacturer: Arechar Healthcare
Dosage Form: Tablets 
Strength: 400mg 
Composition: Imatinib mesylate
Indication: Blood cancer 
Storage: Store at room temperature 

Overview 

Imacine (Imatinib mesylate) tablet is used to treat certain types of cancers (Acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GST), and myelodysplastic/myeloproliferative diseases). This medication belongs to a class of drugs known as tyrosine kinase inhibitors. It works by decreasing the growth of cancer cells and also prevents the multiplication of cancerous cells. It is important to take Imacine medicine as prescribed by your doctor. The recommended dose of Imacine tablet is decided by a doctor according to your previous medical condition and response to the treatment. Regular monitoring of blood cell count and liver function is required during treatment with this medication. 

Pharmacodynamics 

Imatinib Mesylate is a protein-tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome abnormality in CML. It inhibits proliferation and induces apoptosis in BCR-ABL positive cell lines as well as fresh leukemic cells from Philadelphia chromosome-positive chronic myeloid leukemia. After the oral administration, the effect of this medicine can be observed within 2 to 4 hours. 

Usage 

Imacine tablet is an anti-cancer medication and helps to stop the growth of cancer cells in the body. It is advised not to change your regular dosing schedule without taking suggestions from your doctor. Do not take Imacine tablet in the wrong way as it may lead to some serious side effects. Avoid the consumption of alcohol because it may increase the risk of dizziness. Keep yourself hydrated and maintain good nutrition while having treatment with this medicine. If you experience any signs and symptoms while receiving Imacine tablet, inform your doctor immediately.

Interactions 

Imacine tablets can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions 

  • Pimozide 

  • Etanercept 

  • Leflunomide

  • Baricitinib 

  • Carbamazepine 

  • Warfarin 

Disease Interactions

  • Liver impairment 

  • Cardiovascular disease  

  • Bone marrow suppression 

  • Fluid retention 

  • Kidney impairment 

Alcohol Interaction

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol. 

Contraindications 

  • Do not take Imacine tablet if you are allergic to Imatinib mesylate.

  • Imacine (Imatinib mesylate) medicine is not recommended in patients known to be hypersensitive.

 

This medicine may cause some serious and common side effects. Discuss the risks and benefits of Imacine tablet with the doctor before starting the treatment.

Serious side effects 

  • Difficulty in breathing 

  • Irregular heartbeat 

  • Swelling around the eyes 

  • Pale skin 

  • Unusual bleeding 

  • Bloody stool 

  • Swelling of the hands and feet 

  • Bloating 

  • Presence of blood in cough 

  • Fatigue 

Common side effects 

  • Nausea 

  • Diarrhea 

  • Abdominal pain 

  • Joint pain 

  • Headache 

  • Weight gain 

  • Insomnia 

  • Vomiting 

  • Muscle pain 

  • Heartburn 

  • Indigestion 

  • Rash 

  • Bleeding 

  • Mouth ulcers 

  • Constipation 

  • Blurred vision 

  • Indigestion 

  • Dizziness 

  • Weight loss 

  • Change in taste 

  • Joint pain

Note - Immediately contact your medical practitioner if any side effects occur.

 

Take this medicine as prescribed by your doctor. Do not stop or skip your regular dosing schedule of Imacine tablet. 

Missed dose 

  • It is advisable not to miss a dose. If you miss a scheduled dose of Imacine medicine, contact your doctor immediately. 

Overdose 

  • In case of an overdose of Imacine tablets, the doctor will provide emergency medical treatment.

Warnings 

Before starting treatment with Imacine medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk. 

  •  Contraception 

    • Use suitable methods of contraception to prevent pregnancy while taking Imacine tablets. 

  • Children and adolescents 

  • Imacine tablets are advisable for use in children and adolescents with CML.

Warnings for female 

  • Pregnancy

    • Do not use Imacine medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy. 

  • Breastfeeding

    • Imacine (Imatinib mesylate) tablets are not recommended in breastfeeding unless it is required. Please consult with your doctor before starting treatment. 

Precautions 

  • In children, close monitoring of growth parameters is required during treatment with this medication. 

  • Close monitoring of thyroid hormones is required in patients suffering from hypothyroidism. 

  • Imacine tablets may interact with other medications and cause some severe side effects.

  • Inform your doctor if you experience any side effects like -  unusual bleeding, pale skin, difficulty in breathing, swelling around the eyes, heartburn, indigestion, dizziness, fatigue, etc.

  • This medication  may increase the risk of getting infections

  • Imacine tablets should be used with caution in patients who are suffering from heart disease.

Cautions 

  • Do not drive or operate heavy machinery.

  • Do not crush or break the tablet. 

  • Not safe for pregnant women. 

  • Do not breastfeed while receiving this medication.

Q1. What is Imacine (Imatinib mesylate)?

Ans. This medication is used in the treatment of blood cancer and it belongs to a class of drugs known as tyrosine kinase inhibitors. Imacine tablets help to stop the growth of cancer cells in the body. 

Q2. What are the side effects?

Ans. Some common side effects are - mouth ulcers, indigestion, change in taste, weight gain, irregular heartbeat, pale skin, headache, muscle cramps, etc. 

Q3. In what strength is it available?

Ans. Imacine tablet is available in the strength of 400mg. 

Q4.  How does Imacine (Imatinib mesylate) tablet work? 

Ans. It works by stopping the growth of cancer cells and also prevents the multiplication of cancerous cells.

Q5. How to take this medicine?

Ans. It is important to take Imacine tablet as prescribed by your doctor. 

Q6. What are the storage conditions?

Ans. Store this medicine at room temperature. Keep it away from direct heat and light.

Q7. Can I take this medicine during pregnancy? 

Ans. This medication is not recommended during pregnancy.

Q8.  What happens if I miss a dose? 

Ans. If you miss a scheduled dose of Abiracine tablet, contact your doctor immediately.

Q9. Can I consume alcohol while taking Imacine tablet?

Ans. Please consult your doctor before consuming alcohol. 

Q10. Does this medicine affect kidney function? 

Ans. Please consult your doctor before consuming this drug. 

Q11. What should I avoid while receiving this medication? 

Ans. Avoid contact with people who have infections and avoid eating grapefruits.

Q12. Can I take this medicine during breastfeeding? 

Ans. This medicine is not recommended in breastfeeding unless it is necessary. 

Q13. Can I drive after taking this medicine? 

Ans. Imacine tablets may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur.

 

Above Content has been reviewed by Professionals