Marketed By
pfizer ltd
Pack of
28 tablet
Salt Composition
Axitinib
Storage
Keep in cold place
Delivering To: —
All Substitutes
Overview
- Inlyta (axitinib) 5 mg is a medication that is taken orally to help in treating renal cell carcinoma, which is a type of kidney cancer.
- Inlyta is classified as a targeted medication and works by acting as an inhibitor of tyrosine kinases, thus restricting the growth of blood vessels that supply blood to the cancer cells and shrinking their growth.
- Common side effects include hypertension, diarrhea, tiredness, and vomiting.
- Regular monitoring of blood pressure and blood tests is required during treatment.
- Typical dosing is twice daily.
Indication
Kidney Cancer
Uses of Inlyta 5mg Tablet
Advanced Renal Cell Carcinoma (RCC)—Kidney Cancer
Side effects of Inlyta 5mg Tablet
The majority of adverse effects go away as your body becomes used to the medication and doesn't need to be treated. If they continue or you're concerned about them, speak with your doctor. Side effects of Inlyta 5mg are as follws:
Dizziness
Nausea and vomiting
Constipation or diarrhea
Loss of appetite
Weight loss
Headache
Muscle and joint pain
Weakness and fatigue
Dry skin, itching, redness, or hair loss
Nosebleeds
Ringing in the ears
Sore throat
Voice changes
Anemia (low red blood cell count)
Elevated creatinine levels (possible kidney problems)
Dehydration
Palmar-plantar erythrodysesthesia (hand-foot syndrome: redness, swelling, pain in palms/soles)
Severe fatigue with swelling
Chest pain or pressure (may spread to arms, back, neck, or jaw)
Shortness of breath or difficulty speaking
Significant bleeding (such as black stools or coughing up blood)
Dosage and Administration
- Inlyta 5mg tablet comes in tablet form and is usually taken with or without food twice a day or as the doctor prescribes.
- For better results, take Axitinib same time every 12 hours.
- You should not cut, chew, or break the tablet; swallow the whole tablet with water.
- If the patient vomits after taking a tablet, do not give another; take the tablet as per the schedule.
- If the patient feels uncomfortable after starting treatment, inform the doctor immediately.
Mechanism of action
- It targets tyrosine kinases on the surface of VEGFR. Through this, it works by interrupting signals required for tumor proliferation through these receptors.
- The main action of axitinib involves angiogenesis inhibition. This is the development of blood vessels responsible for tumor development.
- It does so mainly through VEGFR-1, -2, and -3 that are highly expressed in advanced renal cell carcinoma (RCC)
- The inhibition of angiogenesis leads to effective starvation of the tumor.
Safety Advice for inlyta 5mg tablet
Alcohol
UNSAFE
Pregnancy
CONSULT YOUR DOCTOR
Breast Feeding
CONSULT YOUR DOCTOR
Driving
DANGER
Kidney
CAUTION
Liver
CAUTION
Missed Doses
In case you missed any dose consult your doctor. Do not take twice the dose to catch up on the missed dose. This will cause severe side effects and impact your overall health.
Quick Tips
- Take Inlyta with or without food, preferably at the same time each day.
- Monitor your blood pressure regularly; report severe headache, vision problems, confusion, nausea, or vomiting.
- Thyroid function should be checked before and during treatment, as hypothyroidism may occur.
- Watch for signs of bleeding (black stools, blood in urine or cough, stomach pain, and headaches) and inform your doctor immediately.
- Stop the medication at least 24 hours before elective surgery to avoid wound‑healing complications.
- Dose reduction may be required in patients with moderate liver impairment (starting dose 2 mg twice daily).
- Use effective contraception during treatment and for one month after stopping, as the tablet is contraindicated in pregnancy.
- Diarrhea is a possible side effect; stay hydrated and seek medical advice if persistent or if blood is present in stools.
Safety Advice
Alcohol
PRECAUTION
Pregnancy
CONSULT YOUR DOCTOR
Breast Feeding
CONSULT YOUR DOCTOR
Driving
DANGER
Kidney
PRECAUTION
Liver
PRECAUTION
FAQs
Inlyta 5mg tablet is used to treat kidney cancer.
The duration of treatment will depend on the stage of cancer and the overall health of the patients.
Driving and operating heavy machinery is not advisable because this tablet makes you feel dizzy.
No, Inlyta 5mg is a targeted treatment called a tyrosine kinase inhibitor rather than a conventional chemotherapy medication.
Take the Inlyta 5mg Tablet right away if you miss a dose. On the other hand, skip the missed dose and resume your usual routine if your next dose is almost due. Avoid taking two doses at once.
Pregnant women should not consume this table because their baby may be affected.
Of course, by preventing the development of blood vessels that nourish cancer, Inylta 5mg can reduce the size and growth possibilities for tumors in certain people.
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References
- Fox, E., Maris, J. M., Widemann, B. C., Goodspeed, W., Goodwin, A., Kromplewski, M., & Blaney, S. M. (2018). A phase 1 study of axitinib in pediatric patients with refractory solid tumors: A Children’s Oncology Group study (ADVL1215). Clinical Cancer Research, 24(14), 3534–3541.
- Fu, L., Liu, Q., Han, Z., Wu, Y., & Jiang, Y. (2023). Axitinib for hepatocellular carcinoma: Mechanisms and emerging immunotherapy combination strategies. Frontiers in Immunology, 14, 1163967.
- Jeong, I. G., Park, J., Ahn, H. K., Park, S. H., Song, C., Hong, B., & Lee, J. L. (2024). Real-world use of axitinib as a second-line therapy in patients with metastatic renal cell carcinoma: A Korean multicenter phase IV study. Investigational and Clinical Urology, 65(2), 136–144 - https://pubmed.ncbi.nlm.nih.gov/39057291/
- Powell, S. F., Choueiri, T. K., Motzer, R. J., Escudier, B., Grunwald, V., Donskov, F., & Rini, B. I. (2023). Final overall survival and biomarker analysis of avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma (JAVELIN Renal 101). European Urology, 84(3), 320–329 - https://pubmed.ncbi.nlm.nih.gov/39057291/
- Teoh, J. Y. C., Leung, C. H., Chan, C. M., Poon, D. M. C., & Ng, C. F. (2024). Systematic review of axitinib for advanced renal cell carcinoma: Real-world evidence and future directions. Cancers, 16(7), 1605
- Voss, M. H., Keegan, M. E., Clark, J. W., Halabi, S., McKay, R. R., Atkins, M. B., & Pal, S. K. (2023). Management of adverse events associated with axitinib plus immune checkpoint inhibitor combinations: A real-world multicenter analysis. Targeted Oncology, 18(3), 319–329 - https://pubmed.ncbi.nlm.nih.gov/32587360/
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