NUBLEXA

Mfd. by :- Bayer Pharma (Fulfilled By : Magicine Pharma)

Nublexa

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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DESCRIPTION

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PACKAGE

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Brand name:- Nublexa  

Generic name:- Regorafenib

Manufacturer:- Bayer Pharma 

Dosage form:- Tablets 

Strength:- 40mg 

Composition:- Regorafenib

Packaging:- 28 tablet (28/strip) 

Indication:- Colorectal, Liver cancer

Storage:- Store at room temperature 

Overview

Nublexa (Regorafenib) tablet is used in the treatment of colorectal cancer. It works by blocking the action of an abnormal protein that multiplies the cancer cells. It is also used to treat a type of tumor that can affect the stomach and intestines. Take this medicine orally with food and take this medicine at the same time to get most of the benefits. Your doctor will decide the dosing schedule according to your medical condition and your response to the treatment. Do not take this medicine in the wrong way as it may lead to some severe side effects. Inform your medical advisor if you are using any other medications. 

Pharmacodynamics of Nublexa (Regorafenib)

Nublexa is an oral tumor deactivation agent that potently blocks multiple protein kinases, including kinases involved in tumor angiogenesis, Oncogenesis, and the tumor microenvironment. In particular, Nublexa inhibits mutated KIT, a major oncogenic driver in gastrointestinal stromal tumors, and thereby blocks tumor cell proliferation. 

Substitutes of Nublexa (Regorafenib)

  • Resihance 

  • Regonat

Side effects of Nublexa (Regorafenib) 

This medicine may cause some serious and unwanted side effects. It requires immediate medical attention otherwise it can also lead to higher risk. Discuss the risks and benefits of this medication with your medical advisor before starting the treatment. 

Common side effects 

  • Vomiting

  • Infection 

  • Weakness 

  • Nausea 

  • Loss of appetite

  • Dizziness 

  • Headache 

  • Anemia 

  • High blood pressure 

  • Low blood platelets 

  • Diarrhea 

  • Blurred vision 

  • Chest pain 

  • Indigestion 

  • Bleeding gums 

  • Stomatitis 

  • Mucosal inflammation 

  • Rash 

  • Dry skin 

  • Coughing up blood

  • Fatigue 

  • Shortness of breath 

  • Nose bleeds 

  • Difficulty in speaking 

  • Dark-colored urine 

  • Anxiety 

  • Weight loss 

  • Swelling 

  • Pounding in ears 

  • Sore throat 

  • Pain 

  • Hair loss 

  • Chills 

Note- please contact your doctor, if you experience any signs and symptoms.

Dosage

Take this medicine as prescribed by your doctor. Nublexa tablet is to be taken with food. Do not crush or chew the tablet. 

Missed dose 

  •  It is advisable not to miss a dose. If you miss a scheduled dose of this medicine, contact your doctor immediately. 

Overdose 

  • In case of an overdose, your doctor will provide emergency medical treatment.

Usage of Nublexa (Regorafenib)

Nublexa tablets are used to treat metastatic colorectal cancer (cancer that starts either in the colon or rectum). This medicine stops the growth of cancer cells and also prevents the multiplication of cancerous cells. Consult your doctor immediately if you experience any symptoms during treatment with this medicine. This medication may take some time to show results. Do not stop taking this medicine unless your medical advisor told you to do so. Regular blood tests are required during treatment with this medicine. Store this medicine at room temperature. Protect it from moisture and heat. 

Warnings

Before starting treatment with Nublexa, please inform your doctor about your previous medical history. If you experience any symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk. 

  •  Contraception 

    • Use effective methods of contraception to prevent pregnancy while taking this medicine. 

  • Children and adolescents 

    • This medicine is not advisable for use in children and adolescents. 

Warnings for female 

  • Pregnancy 

    • Nublexa shouldn’t be used by pregnant women. Regorafenib may cause harm to the baby. It is recommended that this medicine should be avoided during pregnancy. 

  • Breastfeeding 

    • This medicine is not recommended in breastfeeding unless it is necessary. Please consult your medical advisor before starting treatment with this medication.

General warnings and precaution 

  • Increased risk of bleeding may occur with this medicine. 

  • Regular monitoring of blood pressure is required while receiving this medicine. 

  • This medication makes your immune system weak, which increases the risk of infections. 

  • This medication should be used with caution in patients who are suffering from heart diseases. 

  • Avoid contact with people who have infections. 

  • Avoid driving after receiving this medicine because this medicine may cause blurred vision or dizziness 

Cautions

  • Do not crush, chew, or break the tablet. 

  • Not safe for pregnant women. 

  • Do not drive or operate machinery. 

  • May harm the liver. 

  • Do not breastfeed while receiving this medication.

Q1. What is Nublexa (Regorafenib)? 

Ans. Nublexa tablets are used to treat metastatic colorectal cancer (cancer that starts either in the colon or rectum). This medicine stops the growth of cancer cells and also prevents the multiplication of cancerous cells.

Q2. How does the Nublexa tablet work? 

Ans. Nublexa is an anti-cancer medication. It works by blocking the action of an abnormal protein that multiplies the cancer cells. 

Q3. What are the side effects? 

Ans. Some common side effects are:- vomiting, anemia, diarrhea, hair loss, fever, nausea, infection, rash, weakness, blurred vision, dizziness, etc. 

Q4. In what strength is it available? 

Ans. It is available in the strength of 40mg. 

Q5. How to take this medicine? 

Ans. Take this medicine orally with food. Do not skip your dosing schedule.

 Q6. What are the self-care tips? 

Ans. Keep yourself hydrated and maintain good nutrition. 

Q7.Does this affect kidney function?

Ans. Please discuss your medical condition with your doctor before consuming this drug.

Q8. What happens if I miss a dose? 

Ans. If you miss a scheduled dose of this medicine, contact your doctor immediately. 

Q9. Does this affect liver function? 

Ans. The use of this medicine is not recommended in patients with severe liver disease. 

Q10. Can I consume alcohol while taking this medicine? 

Ans. It is not known whether it is safe or not. Please consult your doctor before consuming alcohol. 

Q11. Can I drive after taking this medicine? 

Ans. This medicine may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur. 

Q12. Can I take this medicine during pregnancy? 

Ans. This medicine is not recommended for pregnant women. 

Q13. Can I take this medicine during breastfeeding? 

Ans.  This medicine is not recommended in breastfeeding unless it is necessary.

Q14. What are the storage conditions? 

Ans. Store this medicine at room temperature.

Interactions

Interactions may change how your medication works and increase the risk for side effects. Don’t forget to disclose your previous medical history with your doctor. 

Medicine interaction

  • Clarithromycin

  • Dalteparin 

  •  Heparin 

  • Warfarin 

  • Diclofenac

  • Aspirin 

Disease interaction 

  • This medicine should be used with caution in patients with a history of lung disease. Adjustment of dose and clinical monitoring is required in such cases. 

Alcohol interaction 

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol. 

Contraindications 

  • Nublexa tablet is not recommended for use in patients with a known allergy to Regorafenib. 

  • This medicine is contracted in patients known to be hypersensitive.

Above Content has been reviewed by Professionals