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OLANIB 150MG, 50MG TABLET

Mfd. by :- Everest (Fulfilled By : Magicine Pharma)

Olanib 150mg, 50mg Tablet

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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DESCRIPTION

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PACKAGE

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Brand name – Olanib

Generic name – Olaparib 

Manufacturer – Everest

Strength – 150mg/50mg

Dosage – Tablet

Composition – Olaparib

Indication – Ovarian Cancer

Storage – at room temperature

Overview of Olanib 150mg tablet

Olanib 150mg tablets (Olanib 50mg) is a target therapy medication. It is used in the treatment of ovarian cancer along with fallopian and peritoneal cancers. In addition, it is also used to treat breast cancer and prostate cancer in men. The generic name of this medication is Olaparib and it is a potent PARP inhibitor.

Pharmacodynamics

Olanib tablets inhibit the function of PARP enzymes. PARP stands for poly ADP-ribose polymerase enzymes that are needed for basic cellular functions like DNA transcription and repair. As Olanib inhibits this enzyme it consequently leads to the accumulation of toxic DNA damage. This furthermore leads to genomic instability and triggers cell death.  Also, it increases the formation of the PARP-DNA complex which stops the growth of cancerous cells.

Usage of Olanib

Olanib 50mg (or 150mg) tablets are prescription based. It is used for the treatment of ovarian, peritoneal, fallopian, and breast cancer. The doctor decides the dose and length of the treatment depending on the type and stage of cancer. It is recommended to follow all the advice given thoroughly. Inform the doctor about all the prior medical conditions and medicines you take. It is an oral medication that can be taken with or without food however avoid Seville oranges and grapefruit as they can increase the side effects.

Interactions

With medicines

Olanib tablets can interact with some other prescription and non-prescription medicines and interfere with each other’s workings or increase the side effects. Inform your doctor if you have any of these medicines –

  • Rifampicin
  • Indinavir
  • Erythromycin  
  • Fluconazole
  • Carbamazepine
  • Verapamil
  • Phenytoin

With disease

Some diseases may show interactions with. Hence, consult your doctor if you have any of these conditions –

  • Hepatic complications
  • Renal disorders
  • Pulmonary disorders
  • Blood-related diseases

With alcohol

It is advisable to avoid alcohol with Olanib 150mg and 50mg as their interactions are still unknown.

Contraindication

Olanib 150mg (50mg) tablets should not be given to patients who have allergic responses to it. Also, avoid pregnancy and breastfeeding during the treatment.

Alternate Brands

  • Lynparaza
  • Bracanat
  • Nausea
  • Vomiting
  • Heartburn
  • Headache
  • Dizziness
  • Extreme fatigue
  • Mouth sores
  • Weak immune system
  • Increased bleeding
  • Loss of appetite
  • Muscle or joint and bone pain
  • Blood in urine
  • Blood in stool
  • Weight loss
  • Shortness of breath
  • Wheezing
  • Fever
  • Chills
  • Sore throat
  • Swelling in one leg
  • Chest pain
  • Redness of skin

Olanib 150mg and 50mg tablets are prescription medications hence, it is advisable to follow the advice of the doctor. Olanib is taken orally twice every day and it can be taken with or without food.

Missed dose

Avoid missing any dose. In case you miss a dose of Olanib 50mg tablets (or 150 mg), it is recommended to consult your doctor immediately.

Overdose

In case of an overdose, contact your doctor or any healthcare provider and seek medical attention immediately.

  • Olanib 150mg or Olanib 50mg can cause an allergic reaction in some patients. Therefore it is necessary to gather complete information about the medicine and consult the doctor in case of any component that causes an allergic response.
  • Inform the doctor about all the vitamin supplements, herbal medications, and prescription and non-prescription drugs. 
  • Consult the doctor if you are planning a pregnancy since Olanib can harm the fetus. It is advisable to avoid pregnancy during and till 6 months after the last dose. If you are a male patient with a partner then also avoid pregnancy till 3 months after the last dose.
  • It is advisable to avoid breastfeeding during and till one month after the last dose.
  • Do not donate sperm during and till 3 months after the last dose.
  • It is advisable to avoid eating grapefruit and Seville orange or their juices along with this medication.
  • Avoid taking alcohol during the treatment.
  • Avoid driving or operating heavy machinery.
  • Inform the doctor about the previous medical conditions –
  • Hepatic complications
  • Renal disorders
  • Pulmonary disorders
  • Blood-related diseases

Q:- What is Olanib?

Ans:- Olanib 150mg/50mg is an anticancer tablet that is primarily used in the treatment of ovarian cancer.

Q:- How can I take Olanib tablets?

Ans:- Olanib 50mg / Olanib 150mg tablets are taken orally twice every day. However, it is advisable to follow the prescription given by the doctor.

Q:- Where to store Olanib tablets?

Ans:- It is advisable to store the tablets at a place at room temperature.

Q:- Can I drink alcohol with Olanib 150mg?

Ans:- Avoid drinking alcohol during the treatment with Olanib 150mg tablets even though no interactions of both are known.

Q:- How long is the treatment with Olanib 50mg tablets?

Ans:- The doctor decides the length of the treatment depending on the condition, stage, and health of the patient.

Q:- Can I drive after consuming Olanib 150mg tablets?

Ans:- It is advisable to avoid driving and operating heavy machinery as Olanib 150mg/50mg causes dizziness as one of the side effects.

Q:- Is it safe to take Olanib tablets during pregnancy?

Ans:- Olanib 150mg/50mg can cause harm to the fetus. Hence, it is advisable to avoid pregnancy till 6 months after the last dose.

Q:- What is the strength of Olanib tablets?

Ans:- Olanib tablets are available in two strengths – 150mg and 50mg.

 

References –

Olaparib Uses, Interactions, Mechanism of Action | DrugBank Online. Available at: https://go.drugbank.com/drugs/DB09074.

Olaparib: MedlinePlus Drug Information MedlinePlus. Available at: https://medlineplus.gov/druginfo/meds/a614060.html.

Olaparib (oral route) description and brand names (2023) Mayo Clinic. Available at: https://www.mayoclinic.org/drugs-supplements/olaparib-oral-route/description/drg-20127672.

Above Content has been reviewed by Professionals