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30 Tablets in Bottle
Tenofovir Alfenamide, Emtricitabine, Dolutegravir
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Overview
Spegra 50/200/25mg Tablet is a prescription-based antiretroviral or antiviral drug. It is used in the treatment of HIV (human immunodeficiency virus) infection. The active ingredients of Spegra are Dolutegravir, Emtricitabine, Tenofovir Alfenamide, which belong to the drug class of nucleoside reverse transcriptase inhibitors (NRTIs). This medicine work by increasing the immunity in adults and children above three years. Spegra Tablet is not the permanent cure for HIV, but it has the potential to reduce the chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related conditions.
HIV
Spegra Tablet shows some side effects. Some of the mild ones do not need any medical attention, and they go away as the body adapts to the medicine. It is important to consult your doctor if they persist for a longer time and are deteriorating your health.
Common side effects include:
Nausea
Diarrhea
Vomiting
Weight gain
Headache
Stomach pain
Loss of strength
Sleeplessness
Tiredness and dizziness
Autoimmune disorders
Numbness or pain in the hands or feet
High cholesterol and glucose levels in the blood
Serious side effects are:
Diabetes
Liver problems
Skin rash and itchin
Unusual bleeding
Inform your doctor immediately if you experience any persistent or unusual side effects.
A doctor decides the recommended dose of Spegra 50/200/25mg Tablet according to your previous medical condition and response to the treatment. It is advised to take this medicine after consulting your healthcare expert. This medicine should be taken orally at the same time every day. Please do not crush or chew the medicine and eat it as a whole with a glass of water. This tablet can be taken with or without food.
Spegra Tablet is a combination of three medicines Dolutegravir, Emtricitabine and Tenofovir Alafenamide. It is antiretroviral or antiviral drug used to treat people diagnosed with HIV infection. This tablet works by inhibiting the replication process of HIV infection. It improves the immune system of the patient to fight against infection, controls the virus production, reduces the viral load in the body and slows down the growth of this disease and works on overall health.

Alcohol
consult your doctor
Avoid the consumption of alcohol while taking Spegra Tablet, as alcohol can reduce the effectiveness of the medicine and worsen the symptoms

Pregnancy
consult your doctor
Spegra Tablet is safe for use during pregnancy if prescribed by the doctor. No dosage adjustment is necessary for this Tablet.

Breast Feeding
consult your doctor
Spegra 50/200/25mg Tablet is probably not safe if you're breastfeeding. Kindly consult your doctor.

Driving
unsafe
It is advisable not to drive or operate heavy machinery as you may feel dizzy after taking the Spegra 50/200/25mg Tablet.

Kidney
safe if prescribed
Consumption of Spegra Tablet should be avoided without informing the doctor if you have any kidney-related issues.

Liver
safe if prescribed
Consumption of Spegra Tablet should be avoided without informing the doctor if you have any kidney-related issues
It is advised not to miss any scheduled dosage of the Spegra 50/200/25mg Tablet. In case you miss a dose, consult your doctor immediately.
Don't overdose to compensate for the missed one. Contact your doctor or any healthcare provider and seek medical attention immediately in such cases.
It is advised to use effective birth control methods to avoid pregnancy. Some drugs can cause birth defects, miscarriage, or death to an unborn baby if the mother or father is using this medicine. Moreover, this medicine may pass to the unborn baby.
Consult your doctor if you observe symptoms such as abdominal pain, loss of appetite, dark urine, or yellowing of the eyes or skin. These symptoms indicate the presence of Jaundice in the body.
It is advised to tell your doctor about all medicines (multivitamins, herbal supplements) you're taking currently before starting your course with Spegra 50/200/25mg Tablet. There are chances that many drugs can interact, and some drugs should not be used together.
Inform your healthcare expert in case of a history of severe blood infection, active tuberculosis, liver problems, or any serious health disorder.
Birth control is mandatory in order to avoid transmission of HIV infection to your partner and to avoid an unwanted pregnancy.
No, this medicine is not a permanent cure for HIV. It is an antiretroviral medication that helps to inhibit the multiplication process of the virus and slows down the growth of the disease. It is given as a combination therapy to manage the HIV infection lifetime.
Yes, the Spegra Tablet is an antiretroviral drug belonging to the drug class of nucleoside reverse transcriptase inhibitors (NRTIs).
Common side effects of taking this medicine are diarrhea, headache, fatigue, dizziness, difficulty breathing, Diarrhea, Vomiting, Nausea, Weight gain, and Headache.
Taking this medicine may lead to the development of a skin rash. This rash may become severe or life-threatening in extreme cases. Consult your doctor whenever you notice any skin rashes.
1. Patel, H., Shah, M. P. A., Gajera, M. R. J., & Patel, H. D. (2021). DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF RELATED SUBSTANCES PRESENT IN THE PHARMACEUTICAL DOSAGE FORM OF EMTRICITABINE, TENOFOVIR ALAFENAMIDE AND DOLUTEGRAVIR. Towards Excellence, 13(3).
2. Rathod, S. M., & Patel, P. U. (2022). Chemometrics-assisted spectrophotometric method development and validation for simultaneous estimation of emtricitabine, tenofovir alafenamide fumarate, and dolutegravir sodium in dosage form. Journal of Reports in Pharmaceutical Sciences, 11(1), 41-50.
3. Venter, W. D., Sokhela, S., Simmons, B., Moorhouse, M., Fairlie, L., Mashabane, N., ... & Hill, A. (2020). Dolutegravir with emtricitabine and tenofovir alafenamide or tenofovir disoproxil fumarate versus efavirenz, emtricitabine, and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection (ADVANCE): week 96 results from a randomised, phase 3, non-inferiority trial. The lancet HIV, 7(10), e666-e676.
4. Sax, P. E., Pozniak, A., Montes, M. L., Koenig, E., DeJesus, E., Stellbrink, H. J., ... & Quirk, E. (2017). Coformulated bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir with emtricitabine and tenofovir alafenamide, for initial treatment of HIV-1 infection (GS-US-380–1490): a randomised, double-blind, multicentre, phase 3, non-inferiority trial. The Lancet, 390(10107), 2073-2082.
5. Deeks, E. D. (2018). Bictegravir/emtricitabine/tenofovir alafenamide: a review in HIV-1 infection. Drugs, 78(17), 1817-1828.
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