STIVARGA

Mfd. by :- Natco (Fulfilled By : Magicine Pharma)

Stivarga

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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PACKAGE

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Brand Name: Stivarga   

Generic Name: Regorafenib 

Manufacturer: Bayer Pharma  

Dosage Form: Tablet  

Strength: 40mg  

Composition: Regorafenib 

Packaging: 28 tablet (28/strip)  

Indication: Colorectal and Liver cancer 

Storage: Store at room temperature  

Overview  

Stivarga (Regorafenib) tablet is used in the treatment of liver cancer and colorectal cancer. This tablet works by blocking the action of an abnormal protein that multiplies the cancer cells. It is also used to treat a type of tumor that can affect the stomach, esophagus, or intestines. Do not take this medicine in the wrong way as it may lead to some severe side effects. It is advisable not to change or stop the dose without taking suggestions from your doctor. If you experience any symptoms while receiving this medicine, inform your doctor immediately. Store this medicine at room temperature and keep it away from light and moisture.  

Pharmacodynamics of Stivarga  

Stivarga is a small molecule inhibitor of multiple membrane-bound and intracellular kinases involved in normal cellular functions and pathologic processes such as oncogenesis, tumor angiogenesis, and maintenance of the tumor microenvironment. Stivarga 40 mg tablet has demonstrated anti-angiogenic activity in a rat tumor model and inhibition of tumor growth as well as anti-metastatic activity in several mouse xenograft models including some for human colorectal carcinoma. 

Usage of Stivarga 

Stivarga (Regorafenib) tablet is used to treat metastatic colorectal cancer and a type of liver cancer called hepatocellular carcinoma. This medicine works by stopping the growth of cancer cells. Take this medicine with or without food at the same time every day. Do not miss your regular dosing schedule. The recommended dose is decided by a doctor according to your previous medical condition and response to the treatment. Regular blood tests are required during treatment with this medicine. Do not crush or break the tablet and swallow the whole tablet with a glass of water. 

Substitutes of Stivarga 

  • Resihance  

  • Regonat  

  • Nublexa  

Side effects of Stivarga  

This medicine may cause some mild or severe side effects. Discuss the risks and benefits of this medication with the doctor before starting the treatment. 

Common side effects  

  • Vomiting 

  • Infection  

  • Weakness  

  • Nausea  

  • Anxiety  

  • Weight loss  

  • Swelling  

  • Pounding in ears  

  • Sore throat  

  • Loss of appetite 

  • Dizziness  

  • Headache  

  • Anemia  

  • High blood pressure  

  • Low blood platelets  

  • Diarrhea  

  • Blurred vision  

  • Chest pain  

  • Indigestion  

  • Bleeding gums  

  • Stomatitis  

  • Mucosal inflammation  

  • Rash  

  • Dry skin  

  • Coughing up blood 

  • Fatigue  

  • Shortness of breath  

  • Nose bleeds  

  • Difficulty in speaking  

  • Dark-colored urine  

  • Pain  

  • Hair loss  

  • Chills 

  • Pale skin 

  • Loss of strength  

Note- immediately contact your doctor if any side effects occur.

Dosage of Stivarga

Take this medicine as prescribed by your doctor. Do not skip or miss your dosing schedule. 

Missed dose  

  •  It is advisable not to miss a dose. If you miss a scheduled dose of this medicine, contact your doctor immediately.  

Overdose  

  • In case of an overdose, the doctor will provide emergency medical treatment.  

Warnings of Stivarga

Before starting treatment with the Stivarga tablets, please inform your doctor about your previous medical history. If you experience any symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.  

 

 Contraception  

  • Use effective methods of contraception to prevent pregnancy while taking this medicine.  

  • Children and adolescents  

  • This medicine is not advisable for use in children and adolescents. 

Warnings for female  

Pregnancy 

  • Do not use the Stivarga tablets if you are pregnant or planning to become pregnant. Avoid this medication at the time of pregnancy.  

Breastfeeding 

  • This medicine is not recommended in breastfeeding unless it is necessary. Please consult your medical advisor before starting treatment with this medication. 

Precautions of Stivarga

  • Stivarga tablet may increase the risk of bleeding.  

  • Regular monitoring of blood pressure is required while receiving this medicine.  

  • This medication makes your immune system weak, which increases the risk of infections.  

  • Dose alteration is required for patients who have a history of heart diseases. 

  • Inform your doctor if you experience any side effects like diarrhea, weight loss, anemia, high blood pressure, and vomiting.  

  • Avoid contact with people who have infections. 

Cautions of Stivarga

  • Do not drive or operate heavy machinery.  

  • Not safe for pregnant women.  

  • Do not breastfeed while receiving this medication.  

  • Do not crush or break the tablet.  

Q1. What is Stivarga (Regorafenib)?  

Ans. Stivarga tablets are used in the treatment of liver cancer and colorectal cancer. This medicine helps to stop the growth of cancer cells. 

Q2. How does the Stivarga tablet work?  

Ans. This medicine works by blocking the action of an abnormal protein that multiplies the cancer cells. 

Q3. What are the side effects?  

Ans. Some common side effects are:- vomiting, anemia, diarrhea, hair loss, fever, nausea, infection, rash, weakness, blurred vision, dizziness, etc.  

Q4. In what strength is it available?  

Ans. It is available in the strength of 40mg.  

Q5. How to take this medicine?  

Ans. Take this medicine as prescribed by your doctor. Do not crush or break the tablet.  

Q6. What should I avoid while receiving this medicine? 

Ans. Avoid contact with people who have infections and follow your doctor’s instructions about other activities.  

Q7. What happens if I miss a dose?  

Ans. If you miss a scheduled dose of this medicine, contact your doctor immediately. 

Q8. Can I consume alcohol while taking this medicine?  

Ans. It is not known whether it is safe or not. Please consult your doctor before consuming alcohol. 

Q9. Can I drive after taking this medicine?  

Ans. This medicine may affect your vision. Do not drive if any symptoms occur.  

Q10. Does this medicine affect liver function?  

Ans. Please contact your doctor before consuming this drug. 

Q11. Can I drive after taking this medicine?  

Ans. This medicine may affect your vision. Do not drive if any symptoms occur.  

Q12. Can I take this medicine during breastfeeding?  

Ans. This medicine is not recommended in breastfeeding unless it is necessary. 

Q13. What are the storage conditions?  

Ans. Store this medicine at room temperature.  

Q14. Can I take this medicine during pregnancy? 

Ans. This medicine is not recommended for pregnant women.  

Interaction of Stivarga

Interactions may change how your medication works and increase the risk for side effects. Don’t forget to disclose your previous medical history with the doctor.  

Medicine interactions  

  • Clarithromycin 

  • Apixaban  

  • Dalteparin  

  • Heparin  

  • Desirudin  

  • Warfarin  

  • Diclofenac 

  • Aspirin  

  • Clopidogrel 

Disease interaction   

  • This medicine should be used with caution in patients with a history of lung disease. Dose alteration and frequent clinical monitoring are required in such cases.  

Alcohol interaction  

  • Interaction with alcohol is unknown. Please consult your doctor before consuming this drug.  

Contraindications of Stivarga

  • Do not use this medicine if you are allergic to Regorafenib.   

  • This medicine is not recommended in patients known to be hypersensitive. 

Above Content has been reviewed by Professionals